- Research article
- Open Access
- Open Peer Review
The effectiveness of integrative medicine interventions on pain and anxiety in cardiovascular inpatients: a practice-based research evaluation
BMC Complementary and Alternative Medicinevolume 14, Article number: 486 (2014)
Pain and anxiety occurring from cardiovascular disease are associated with long-term health risks. Integrative medicine (IM) therapies reduce pain and anxiety in small samples of hospitalized cardiovascular patients within randomized controlled trials; however, practice-based effectiveness research has been limited. The goal of the study is to evaluate the effectiveness of IM interventions (i.e., bodywork, mind-body and energy therapies, and traditional Chinese medicine) on pain and anxiety measures across a cardiovascular population.
Retrospective data obtained from medical records identified patients with a cardiovascular ICD-9 code admitted to a large Midwestern hospital between 7/1/2009 and 12/31/2012. Outcomes were changes in patient-reported pain and anxiety, rated before and after IM treatments based on a numeric scale (0-10).
Of 57,295 hospital cardiovascular admissions, 6,589 (11.5%) included IM. After receiving IM therapy, patients averaged a 46.5% (p-value < 0.001) decrease in pain and a 54.8% (p-value < 0.001) decrease in anxiety. There was no difference between treatment modalities on pain reduction; however, mind-body and energy therapies (p-value < 0.01), traditional Chinese medicine (p-value < 0.05), and combination therapies (p-value < 0.01) were more effective at reducing anxiety than bodywork therapies. Each additional year of age reduced the odds of receiving any IM therapy by two percent (OR: 0.98, p-value < 0.01) and females had 96% (OR: 1.96, p-value < 0.01) higher odds of receiving any IM therapy compared to males.
Cardiovascular inpatients reported statistically significant decreases in pain and anxiety following care with adjunctive IM interventions. This study underscores the potential for future practice-based research to investigate the best approach for incorporating these therapies into an acute care setting such that IM therapies are most appropriately provided to patient populations.
Pain and anxiety occurring from acute care for cardiovascular disease (CVD) are associated with long-term health risks. Specifically, preoperative anxiety and acute postoperative non-anginal pain in cardiac patients have been found to predict persistent postoperative pain up to 24 months after surgery . Furthermore, anxiety shortly after hospitalization for myocardial infarction has been reported as a strong predictor of recurrent myocardial infarction . Given that pain and anxiety symptoms add to the physical and psychosocial burden of post-operative CVD patients, it is important to find effective approaches to ameliorate these symptoms.
Pharmacological symptom management among cardiovascular patients, while often appropriate and necessary, presents challenges such as side effects, limited effectiveness, and risk of adverse events . In 2005, the American College of Cardiology Foundation Task Force recommended consideration of non-pharmacological options for cardiovascular patients, including the use of complementary and alternative medicine (CAM) therapies . A 2012 systematic review of hospitals and outpatient clinics reported that between four and sixty-one percent of cardiovascular patients use CAM for managing cardiovascular conditions and maintaining general health . Integrative medicine (IM) includes the use of CAM therapies, such as massage, acupuncture, and mind-body therapies, in conjunction with conventional medicine.
Several systematic reviews report on efficacy of IM for CVD-related outcomes and risk factors including blood pressure [6–9], blood lipids and cholesterol , and psychosocial outcomes  in outpatient settings. Although there is some evidence for efficacy, conclusions are limited by methodological challenges [4, 6–9].
For inpatients with cardiovascular diagnoses, randomized controlled trials specifically focused on the use of IM therapies for symptom management have reported improvements in pain and anxiety, among other outcomes [10–17]. Trials are important for testing the efficacy of these therapies; however, it has been suggested that the evidence hierarchy that prioritizes RCTs over other methods may warrant revising for the examination of certain interventions . Real-world observational data is critical for better understanding the effectiveness of integrative therapies for cardiovascular inpatients , and observational methods may be particularly appropriate for studying IM, despite the inherent limitation of not being experimental . Practice-based research is also important for improving clinical practice by delivering recommended care in the most appropriate manner for specific populations [18, 21].
In 2010, our research group reported a 55.8% average reduction in pain with IM use across 1,837 inpatients at Abbott Northwestern Hospital (ANW), based on a retrospective medical record review; however, results for cardiovascular patients were not separately analyzed at that time . In the current study, we evaluate the effectiveness of IM therapy, as an adjunct to standard care, for treating pain and anxiety, focusing on a large, inpatient cardiovascular population at ANW. To our knowledge, this is the first study in which multiple IM therapies are studied using practice-based research methodology among cardiovascular inpatients to treat pain and anxiety.
Study design and setting
This retrospective, practice-based research study of cardiovascular inpatients was conducted at ANW, a 630-bed teaching and specialty hospital in Minneapolis, MN. The Penny George Institute for Health and Healing (PGIHH) at ANW was founded in 2003 and offers hospitalized patients, through electronic physician and nurse referrals, a wide-array of integrative health services at no charge to patients . All IM practitioners at PGIHH are formally trained and have necessary licensure and/or certification in their area of specialty (e.g., aromatherapy, acupuncture, massage, music). Referral criteria include: (a) the patient is able to participate in integrative health intervention, and (b) patient concerns include pain, anxiety/stress, elimination problems, nausea/vomiting, insomnia, coping with change in health/well-being, or maintaining/prolonging a pregnancy.
All cardiovascular inpatients age 18 years or older at ANW, who were admitted between July 1, 2009 and December 31, 2012, were included in the study population. Patients seen as outpatients, in the emergency room, and who were in the hospital solely for observation were excluded. Medical record data were obtained on all eligible inpatients and cardiovascular patients were retrospectively identified. All patients whose medical record data were obtained gave written permission upon hospital admission to use their records for research purposes.
The study population included those with diseases of the circulatory system, identified using the International Classification of Diseases (ICD), 9th Revision, Clinical Modification diagnosis codes (390-459). Any admission that had at least one of these ICD-9 codes as the admission’s primary or secondary diagnosis or any hospital encounter-level diagnosis was eligible for the study.
We created non-mutually exclusive indicators pertaining to five circulatory system diseases: diseases of arteries, arterioles and capillaries (440-448); cerebrovascular disease (430-438); hypertensive disease (401-405); ischemic heart disease (410-414); and diseases of pulmonary circulation (415-417). Patients of all other circulatory system diseases were grouped into an ‘other’ category.
The study was approved by the Institutional Review Board of Allina Health with a waiver of informed consent.
Demographic and admission characteristics
Data extracted from medical records included patient age at time of admission, sex, race, marital status, and health insurance status. The data included the All Patient Refined Diagnostic Related Groups (APR-DRG)  severity of illness measures calculated from patients’ diagnoses codes. The measure includes four categories of severity: 1) minor, 2) moderate, 3) major, and 4) extreme. Data pertaining to each IM session were routinely documented in a customized documentation flowsheet within the medical records.
Integrative medicine therapies
IM practitioners used their clinical judgment to provide therapies, within their scope of practice, they deemed necessary and therapeutic for each patient, after consulting with the patient. Many patients received IM therapy numerous times throughout their hospital admission. The term ‘session’ is used to define each unique administration of IM therapy, distinguished by time of procedure, within a hospital admission. For the present analyses, IM therapies were placed into one of three broad categories: bodywork (BW), which included craniosacral therapy, medical massage, and reflexology; mind-body and energy therapies (MBE), which was divided into separate mind-body and energy subcategories; and traditional Chinese medicine (TCM), which included acupressure, acupuncture, and Korean hand therapy. Importantly, patients could receive therapy from more than one category during each session, which has been defined as combination therapies. The presence or absence of each of these IM therapies was coded at each session such that BW, MBE, TCM, and any combination of these therapies were mutually exclusive.
Pain and anxiety scores
IM practitioners collected patients’ self-reported pain and anxiety scores directly prior to and after each IM session. Practitioners requested patients to provide a single number to indicate the level of pain they were currently experiencing on an 11-point numeric rating scale where 0 was defined as ‘no pain’ and 10 was defined as ‘worst pain imaginable’. Similarly, practitioners recorded anxiety scores using the same methodology, where 0 was ‘no anxiety’ and 10 was ‘worst anxiety imaginable’. The primary endpoints were changes in pain and anxiety scores, calculated by subtracting the pre-score from the post-score. Zero to 10 numeric rating scales for pain have been found valid and reliable [25, 26].
Analytic data set
A total of 57,444 cardiology-related hospital admissions were identified from medical records. During data cleaning, 149 hospital admissions were removed due to missing demographic data (51 admissions) or inability to determine severity of illness (98 admissions), resulting in 57,295 cardiology admissions from 37,259 unique patients. Of the 57,295 admissions, 6,589 (11.5%) had 16,344 IM therapy sessions (average of 2.48 per admission). In many cases, practitioners were unable to collect pre- or post-pain and anxiety scores or patients reported no pain or anxiety. Only patients who reported pre- and post-pain scores and/or pre- and post-anxiety scores, and pre-pain/pre-anxiety scores greater than zero, were included in the subsequent analyses examining changes in pain and anxiety after receiving IM therapy.
Because IM therapies were observed at the hospital admission level, but pain and anxiety scores were assessed at the IM session level, one session was randomly selected from each remaining hospital admission in order to keep the level of analysis consistent between the selection and score change equations (see below). Thus, we dropped all hospital admissions with only missing scores or pre-pain or -anxiety scores equal to zero. This method produced a sample of 54,163 hospital admissions for the pain model, of which 3,457 (6%) had IM therapy, and 52,572 admissions for the anxiety model, of which 1,866 (4%) had IM therapy.
IM therapy utilization
Logistic regression was used to predict the probability of receiving any IM therapy during a hospital admission as a function of patient demographics, circulatory system disease diagnosis, severity, and health insurance status, and odds ratios for each covariate are presented. A p-value of less than 0.05 was used to signify statistical significance. We used a random sample of 25,000 observations to test the goodness-of-fit for our model using the Hosmer-Lemeshow test . We did not use the full sample because the Hosmer-Lemeshow test has been shown to likely reject the null hypothesis of a good fit even for models that fit well when the sample size is greater than 25,000 due to increased statistical power . The percent of admissions correctly classified by the model were also calculated.
Pain and anxiety
First, to determine if IM therapies were associated with reductions in pain and anxiety, paired t-tests were conducted using the null hypothesis that the pre- and post-pain or anxiety scores were equal.
Next, multivariate regression was used to estimate reductions in pain and anxiety during IM sessions. Because patients receiving IM therapy may systematically differ from the general sample of cardiovascular patients, an ordinary least squares model could produce bias parameters when generalizing results. To address this bias, a Heckman selection model  was used to account for selection into the sample of IM therapy recipients.
To correctly identify the parameters that affect pain and anxiety, at least one variable in the selection-equation (i.e. utilization of IM therapy) should be specified which predicts IM therapy use, but does not affect changes in pain or anxiety. Since marital status and health insurance status were expected to fit this criterion, our model predicted selection into the sample of IM sessions using all patient demographic, circulatory system disease diagnosis, severity, and health insurance variables (the same set of covariates as our logistic regression predicting IM therapy use). Changes in pain and anxiety scores were estimated using diagnosis, age, sex, race, severity, and the inverse Mills ratio calculated from the selection-equation to control for selection. Additionally, we estimated a second model, which included IM therapy categories, to determine if differential effects between the categories existed.
All analyses were conducted in Stata Version 13 (StataCorp LP; College Station, TX).
Of the 57,295 hospital admissions over the study period, 6,589 (11.5%) included IM therapy (Table 1). The mean age of inpatients utilizing IM therapies (63.5 years) was approximately four years younger than inpatients not receiving IM therapies (67.8 years). Fifteen percent of women received IM therapy compared to only 9% of men. IM hospital admissions were comprised of patients with significantly higher illness severity. A total of 16,344 IM therapy sessions were administered for an average of 2.48 sessions per hospital admission (Table 2). BW comprised 45.7% of IM sessions compared to 12.6% for MBE, 18.7% for TCM, and 23.0% for combination therapies.
IM therapy utilization analysis
Similar to our descriptive statistics, older patients had reduced odds of receiving any IM therapy in our logistic regression model (Table 3), as each additional year of age decreased the odds of any IM therapy use by 2% (odds ratio (OR): 0.98, p-value < 0.01). Females had 96% (OR: 1.96, p-value < 0.01) higher odds of receiving any IM therapy during a hospital admission compared to males. Compared to other diseases of the circulatory system, admissions from hypertensive disease (OR: 1.48, p-value < 0.01), and diseases of pulmonary circulation (OR: 1.23, p-value < 0.01) were associated with increased odds of receiving IM therapy, while ischemic heart disease (OR: 0.73, p-value < 0.01) and diseases of arteries, arterioles, and capillaries (OR: 0.75, p-value < 0.01) had reduced odds of receiving IM therapy.
The p-value from a Hosmer-Lemeshow test was 0.58, indicating a good fit. The model correctly classified 88% of hospital admissions as receiving IM or not receiving IM. Although this result was driven by the model’s under-prediction of IM hospital admissions and the large proportion of non-IM hospital admissions, there was a significant difference (p-value < 0.001) in the predicted probability of receiving IM therapy between the IM hospital admissions group (predicted probability = 0.16) and the non-IM hospital admissions group (predicted probability = 0.11).
Pain and anxiety analysis
Sessions with IM therapy resulted in, on average, a 46.5% (p-value < 0.001) decrease in pain score (Table 4). Anxiety scores decreased by an average of 54.8% (p-value < 0.001) after the administration of IM therapies (Table 4).
A Heckman selection model was used to account for selection into the sample of IM therapy recipients. Results from this model predict that for a male with mean age (67.3), mean inverse Mills ratio (2.05), and the modal value of all categorical variables (i.e. White, hypertension diagnosis, and moderate severity), IM therapy was associated with a 1.81 (p-value < 0.001) point reduction in pain (calculated from coefficients shown in Base Model; Table 5). This result represents a 36.2% (p-value < 0.001) reduction in pain for a male with the mean pain pre-score (5.00). For a female with the same admission attributes, IM therapy was associated with a 40.6% (p-value < 0.001) reduction in pain. When IM therapy categories were included in the regression analysis, we found no significant difference by IM therapy type. The inverse Mills ratio had an insignificant effect on pain, suggesting that selection bias was not present.
The Heckman selection model predicted a 2.28 (p-value < 0.001) point decrease (Table 5) or a 41.6% (p-value < 0.001) reduction in anxiety score for a male with mean age (67.3), mean inverse Mills ratio (2.36), and the modal value of all categorical variables with the mean anxiety pre-score (5.48). For females, IM therapy was associated with a 51.6% (p-value < 0.001) reduction in anxiety. At the mean pre-anxiety score, MBE (12.2 percentage points), TCM (7.7 percentage points), and combination (6.2 percentage points) therapies were all more effective than BW therapies. Additionally, MBE therapy was 6.0 percentage points more effective than combination therapy. The inverse Mills ratio had an insignificant effect on anxiety, suggesting that selection bias was not present.
This practice-based research study, using routinely-collected electronic medical record data, assessed the effectiveness of adjunctive IM therapy on pain and anxiety among cardiovascular inpatients. Of 57,295 hospital admissions over the study period, 6,589 (11.5%) included IM therapy. Older patients had reduced odds of receiving any IM therapy and females had 96% higher odds of receiving any IM therapy compared to males. After receiving IM therapy, patients averaged a 46.5% reduction in pain and a 54.8% reduction in anxiety. For acute pain measured by a 0-10 numeric rating scale, a clinically significant reduction in pain is 20% for minimal noticeable improvement by patients, and between 35% and 44% reduction for a more substantial improvement (for patients with moderate or severe baseline pain, respectively) ; therefore, our results may be interpreted as clinically significant as well as statistically significant. The changes in pain and anxiety we observed may be in addition to or concurrent with changes from analgesics and psychoactive medications or other medical therapies. This study found no difference between treatment modalities on pain reduction; however, MBE, TCM, and combination therapies were all more effective at reducing anxiety than BW therapies.
Hospital-based IM is an emerging field encompassing a wide range of practice models and arrays of services offered, and both RCTs and observational studies comprise a relatively small portion of the evidence base in the IM field . The present results are generally consistent with previous reports of CAM for cardiovascular inpatients, although research to date among cardiovascular inpatient populations focuses only on bodywork and mind-body and energy therapies, not traditional Chinese medicine/acupuncture modalities. Several randomized trials involving preoperative  and postoperative [13–15] cardiovascular inpatients compared massage therapy to standard care with relaxation or rest and reported significant reductions in pain and anxiety scores on a 0-10 scale. A 2006 report of a randomized trial of open heart surgery patients described an unquantified reduction in pre- and postoperative pain in the intervention arm (a package of CAM therapies including guided imagery and light massage) compared with the standard care control . A randomized trial among cardiac inpatients treated with healing touch found a statistically significant 6.3 point reduction in anxiety as measured by the State Trait Anxiety Inventory (STAI) . One randomized trial reported statistically non-significant changes in pain and anxiety among post-surgical cardiac patients receiving foot massage and guided relaxation compared to controls; however, although not significant, the authors reported a trend indicating the interventions appeared to be effective . Another randomized trial of massage reported non-significant changes in pain and anxiety in the intervention group , but as noted by Braun and colleagues, the standard massage sequence used in that study may have limited the potential efficacy .
The present study is unique for its practice-based observational design and large sample of cardiovascular inpatients. Prior investigations have been randomized trials with smaller sample sizes and more limited scope [10, 11, 13–17, 32]. Observational data are important for understanding real-world clinical effectiveness [19, 21], and appropriately analyzed observational data have been found to complement the results of randomized trials of cardiovascular outcomes . Given the high levels of CAM or IM usage by cardiovascular patients , practice-based observational research on IM is important for the evidence base on management of CVD symptoms and recovery. An important strength of this study is our use of a Heckman selection model to adjust for any non-random selection of whether patients received IM therapy. As a result of this adjustment, our results are generalizable to cardiovascular patients at ANW. These results, however, may not generalize to other hospital settings.
This study is not without limitations. First, the present results reflect only short-term changes in pain and anxiety. Because clinical relevance may be limited with a focus on short-term changes, further investigation into the long-term effects of IM on pain and anxiety should be considered. Second, the IM practitioner who delivered the IM therapy was also responsible for collection of the pre- and post-IM therapy pain and anxiety scores. As a result, the potential exists for social desirability or other response or reporting bias. However, provider-collected scores are reflective of how pain and other symptoms are assessed in a real-world acute care setting. Physicians, nurses, and other care providers regularly ask patients to self-report their rating of symptoms, and commonly used measures such as the numeric rating scale have been reported on [25, 26]. It has been recommended that clinical decisions be based on information collected in this way . Third, the effects of IM on pain scores are not separated from the pain reduction impact of pain medications. Our findings only reflect changes in pain and anxiety when IM therapies are provided adjunctively to standard medical care, which may include use of analgesics and psychoactive medications. However, because pain and anxiety are often only partially resolved by medications [35–37], investigating the use of IM therapies in conjunction with standard medical care is an important next step in learning how to better manage pain and anxiety in an acute care setting. Future practice-based research should explore the interactive effects of IM therapy and pain medication by, for example, including the timing of medication use in relation to provision of the IM therapy. Finally, this study did not explore the potential biological mechanisms of IM underlying the observed pain and anxiety reduction; this area of exploration is additionally warranted in future practice-based research.
This study provided a unique opportunity to describe and investigate the effectiveness of delivering IM therapy to cardiovascular inpatients. Our results suggest that after receiving adjunctive IM therapies, cardiovascular inpatients reported statistically significant decreases in pain and anxiety. This study lays preliminary groundwork for future practice-based research to investigate the best approach for incorporating these therapies into an acute care setting such that IM therapies are most appropriately provided to patient populations.
Complementary and alternative medicine
Abbott Northwestern Hospital
Penny George Institute for Health and Healing
International Classification of Diseases
All Patient Refined Diagnostic Related Groups
Mind-body and energy therapies
Traditional Chinese medicine.
Choinière M, Watt-Watson J, Victor J, Baskett R, Bussières J, Carrier M, Cogan J, Costello J, Feindel C, Guertin M, Racine M, Taillefer MC: Prevalence of and risk factors for persistent postoperative nonanginal pain after cardiac surgery: a 2-year prospective multicentre study. CMAJ. 2014, 186 (7): E213-E223. 10.1503/cmaj.131012.
Roest A, Heideveld A, Martens E, de Jonge P, Denollet J: Symptom dimensions of anxiety following myocardial infarction: associations with depressive symptoms and prognosis. Health Psychol. 2014, 33 (12): 1468-1476.
Clarke H, Soneji N, Ko D, Yun L, Wijeysundera D: Rates and risk factors for prolonged opioid use after major surgery: population based cohort study. BMJ. 2014, 348: g1251-10.1136/bmj.g1251.
Vogel JH, Bolling SF, Costello RB, Guarneri EM, Krucoff MW, Longhurst JC, Olshansky B, Pelletier KR, Tracy CM, Vogel RA, Abrams J, Anderson JL, Bates ER, Brodie BR, Grines CL, Danias PG, Gregoratos G, Hlatky MA, Hochman JS, Kaul S, Lichtenberg RC, Lindner JR, O’Rourke RA, Pohost GM, Schofield RS, Shubrooks SJ, Tracy CM, Winters WL, American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine): Integrating complementary medicine into cardiovascular medicine. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine). J Am Coll Cardiol. 2005, 46 (1): 184-221. 10.1016/j.jacc.2005.05.031.
Grant S, Bin Y, Kiat H, Chang D: The use of complementary and alternative medicine by people with cardiovascular disease: a systematic review. BMC Public Health. 2012, 12: 299-10.1186/1471-2458-12-299.
Dickinson H, Campbell F, Beyer F, Nicolson D, Cook J, Ford G, Mason J: Relaxation therapies for the management of primary hypertension in adults: a Cochrane review. J Hum Hypertens. 2008, 22 (12): 809-820. 10.1038/jhh.2008.65.
Nahas R: Complementary and alternative medicine approaches to blood pressure reduction: An evidence-based review. Can Fam Physician. 2008, 54 (11): 1529-1533.
Wang J, Xiong X, Liu W: Acupuncture for essential hypertension. Int J Cardiol. 2013, 169 (5): 317-326. 10.1016/j.ijcard.2013.09.001.
Ospina MB, Bond K, Karkhaneh M, Buscemi N, Dryden DM, Barnes V, Carlson LE, Dusek JA, Shannahoff-Khalsa D: Clinical trials of meditation practices in health care: characteristics and quality. J Altern Complement Med. 2008, 14 (10): 1199-1213. 10.1089/acm.2008.0307.
Wentworth LJ, Briese LJ, Timimi FK, Sanvick CL, Bartel DC, Cutshall SM, Tilbury RT, Lennon R, Bauer BA: Massage therapy reduces tension, anxiety, and pain in patients awaiting invasive cardiovascular procedures. Prog Cardiovasc Nurs. 2009, 24 (4): 155-161. 10.1111/j.1751-7117.2009.00054.x.
MacIntyre B, Hamilton J, Fricke T, Ma W, Mehle S, Michel M: The efficacy of healing touch in coronary artery bypass surgery recovery: a randomized clinical trial. Altern Ther Health Med. 2008, 14 (4): 24-32.
Friedman RS, Burg MM, Miles P, Lee F, Lampert R: Effects of Reiki on autonomic activity early after acute coronary syndrome. J Am Coll Cardiol. 2010, 56 (12): 995-996. 10.1016/j.jacc.2010.03.082.
Bauer BA, Cutshall SM, Wentworth LJ, Engen D, Messner PK, Wood CM, Brekke KM, Kelly RF, Sundt TM: Effect of massage therapy on pain, anxiety, and tension after cardiac surgery: a randomized study. Complement Ther Clin Pract. 2010, 16 (2): 70-75. 10.1016/j.ctcp.2009.06.012.
Cutshall SM, Wentworth LJ, Engen D, Sundt TM, Kelly RF, Bauer BA: Effect of massage therapy on pain, anxiety, and tension in cardiac surgical patients: a pilot study. Complement Ther Clin Pract. 2010, 16 (2): 92-95. 10.1016/j.ctcp.2009.10.006.
Braun LA, Stanguts C, Casanelia L, Spitzer O, Paul E, Vardaxis NJ, Rosenfeldt F: Massage therapy for cardiac surgery patients--a randomized trial. J Thorac Cardiovasc Surg. 2012, 144 (6): 1453-1459. 10.1016/j.jtcvs.2012.04.027. 1459.e1451
Kshettry VR, Carole LF, Henly SJ, Sendelbach S, Kummer B: Complementary alternative medical therapies for heart surgery patients: feasibility, safety, and impact. Ann Thorac Surg. 2006, 81 (1): 201-205. 10.1016/j.athoracsur.2005.06.016.
Hattan J, King L, Griffiths P: The impact of foot massage and guided relaxation following cardiac surgery: a randomized controlled trial. J Adv Nurs. 2002, 37 (2): 199-207. 10.1046/j.1365-2648.2002.02083.x.
Atkins D: Creating and synthesizing evidence with decision makers in mind: integrating evidence from clinical trials and other study designs. Med Care. 2007, 45 (10 Supl 2): S16-S22.
Black N: Why we need observational studies to evaluate the effectiveness of health care. Bmj. 1996, 312 (7040): 1215-1218. 10.1136/bmj.312.7040.1215.
Bell IR, Caspi O, Schwartz GE, Grant KL, Gaudet TW, Rychener D, Maizes V, Weil A: Integrative medicine and systemic outcomes research: issues in the emergence of a new model for primary health care. Arch Intern Med. 2002, 162 (2): 133-140. 10.1001/archinte.162.2.133.
Westfall JM, Mold J, Fagnan L: Practice-based research–“Blue Highways” on the NIH roadmap. Jama. 2007, 297 (4): 403-406. 10.1001/jama.297.4.403.
Dusek J, Finch M, Plotnikoff G, Knutson L: The impact of integrative medicine on pain management in a tertiary care hospital. J Patient Saf. 2010, 6 (1): 48-51. 10.1097/PTS.0b013e3181d10ad5.
Knutson L, Johnson PJ, Sidebottom A, Fyfe-Johnson A: Development of a hospital-based integrative healthcare program. J Nurs Adm. 2013, 43 (2): 101-107. 10.1097/NNA.0b013e31827f2229.
3M Health Information Systems: All Patient Refined Diagnosis Related Groups. 2003, Wallingford, CT: 3M Health Information Systems, 20.0:
Gagliese L, Weizblit N, Ellis W, Chan VW: The measurement of postoperative pain: a comparison of intensity scales in younger and older surgical patients. Pain. 2005, 117 (3): 412-420. 10.1016/j.pain.2005.07.004.
Paice JA, Cohen FL: Validity of a verbally administered numeric rating scale to measure cancer pain intensity. Cancer Nurs. 1997, 20 (2): 88-93. 10.1097/00002820-199704000-00002.
Hosmer D, Lemeshow S: Applied Logistic Regression. 2000, New York: Wiley
Paul P, Pennell ML, Lemeshow S: Standardizing the power of the Hosmer-Lemeshow goodness of fit test in large data sets. Stat Med. 2013, 32 (1): 67-80. 10.1002/sim.5525.
Heckman J: Sample selection bias as a specification error. Econometrica. 1979, 47 (1): 153-161. 10.2307/1912352.
Cepeda MS, Africano JM, Polo R, Alcala R, Carr DB: What decline in pain intensity is meaningful to patients with acute pain?. Pain. 2003, 105 (1–2): 151-157.
Coulter ID, Khorsan R, Crawford C, Hsiao AF: Integrative health care under review: an emerging field. J Manipulative Physiol Ther. 2010, 33 (9): 690-710. 10.1016/j.jmpt.2010.08.007.
Albert NM, Gillinov AM, Lytle BW, Feng J, Cwynar R, Blackstone EH: A randomized trial of massage therapy after heart surgery. Heart Lung. 2009, 38 (6): 480-490. 10.1016/j.hrtlng.2009.03.001.
Hlatky M, Califf R, Harrell FJ, Lee K, Mark D, Pryor D: Comparison of predictions based on observational data with the results of randomized controlled clinical trials of coronary artery bypass surgery. J Am Coll Cardiol. 1988, 11 (2): 237-245. 10.1016/0735-1097(88)90086-1.
Acute Pain Management Guideline Panel: 2. Process of Pain Assessment and Reassessment. (AHCPR Clinical Practice Guidelines, No 1) Acute Pain Management: Operative or Medical Procedures and Trauma. 1992, Rockville (MD): Agency for Health Care Policy and Research (AHCPR),http://www.ncbi.nlm.nih.gov/books/NBK52148/,
Mitchell M: Pain management in day-case surgery. Nurs Stand. 2004, 18 (25): 33-38. 10.7748/ns2004.03.18.25.33.c3559.
Yosselson-Superstine S, Gutman R, Magora F: The propriety of narcotic usage in hospitalized patients. J Clin Hosp Pharm. 1986, 11 (1): 55-60.
Schosser A, Kasper S: The role of pharmacogenetics in the treatment of depression and anxiety disorders. Int Clin Psychopharmacol. 2009, 24 (6): 277-288. 10.1097/YIC.0b013e3283306a2f.
The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/14/486/prepub
This work was partially supported by the National Center for Complementary & Alternative Medicine of the National Institutes of Health (grant number R01 AT006518 to JD). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work was also supported by the George Family Foundation, Abbott Northwestern Hospital, the Margaret and Angus Wuertle Fund of the Minneapolis Foundation, and the Abbott Northwestern Hospital Foundation.
The authors declare that they have no competing interests.
JRJ drafted the original manuscript and led study coordination. DJC conducted the data analysis and contributed to interpretation of the findings and writing of the manuscript. KHG participated in a review of the literature and contributed to writing of the manuscript. MDF participated in the data analysis and interpretation of the findings. RLR participated in data collection and cleaning. CJB provided important intellectual insight and revisions to the manuscript. JAD conceived of the study and participated in its design and coordination. All authors read and approved the final manuscript.