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  1. Content type: Research article

    Inflammation has been found to be associated with many neurodegenerative diseases, including Parkinson’s and dementia. Attenuation of microglia-induced inflammation is a strategy that impedes the progression o...

    Authors: Ming-Yii Huang, Chia-En Tu, Shu-Chi Wang, Yung-Li Hung, Chia-Cheng Su, Shih-Hua Fang, Chi-Shuo Chen, Po-Len Liu, Wei-Chung Cheng, Yu-Wei Huang and Chia-Yang Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:221

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  2. Content type: Research article

    Alcohol is consumed almost worldwide and is the most widely used recreational drug in the world. Harmful use of alcohol is known to cause a large disease-, social- and economic burden on society. Only a few st...

    Authors: Kristina Sivertsen, Marko Lukic and Agnete E. Kristoffersen

    Citation: BMC Complementary and Alternative Medicine 2018 18:239

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  3. Content type: Research article

    In Korea, there are two types of medical doctors: one practises conventional medicine (hereafter called a physician), and the other practises traditional medicine (hereafter called a Korean medical doctor). Th...

    Authors: Ju Ah Lee, Yui Sasaki, Ichiro Arai, Ho-Yeon Go, Sunju Park, Keiko Yukawa, Yun Kung Nam, Seong-Gyu Ko, Yoshiharu Motoo, Kiichiro Tsutani and Myeong Soo Lee

    Citation: BMC Complementary and Alternative Medicine 2018 18:238

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  4. Content type: Research article

    Cancers and microbial infections are still a major health problem, therefore research on new anticancer and antimicrobial agents ought to be continued. Natural products including essential oils from medicinal ...

    Authors: Ramzi A. Mothana, Jamal M. Khaled, Omar M. Noman, Ashok Kumar, Mohamed F. Alajmi, Adnan J. Al-Rehaily and Mine Kurkcuoglu

    Citation: BMC Complementary and Alternative Medicine 2018 18:237

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  5. Content type: Research article

    Feifukang (FFK) is a traditional Chinese medicine composed of herbs that protect lung function. However, difficulty arises regarding the clinical application of FFK due to the complex mechanism of Chinese medi...

    Authors: Hongbo Li, Zhenkai Wang, Jie Zhang, Youlei Wang, Chen Yu, Jinjin Zhang, Xiaodong Song and Changjun Lv

    Citation: BMC Complementary and Alternative Medicine 2018 18:234

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  6. Content type: Research article

    Sotetsuflavone is isolated from Cycas revoluta Thunb., which has biological activity against tumors. However, the anti-proliferative effects of sotetsuflavone on A549 cells and its mechanism are not fully elucida...

    Authors: Shaohui Wang, Yanlan Hu, Yu Yan, Zhekang Cheng and Tongxiang Liu

    Citation: BMC Complementary and Alternative Medicine 2018 18:235

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  7. Content type: Research article

    Cancer-related anorexia remains one of the most prevalent and troublesome clinical problems experienced by patients with cancer during and after therapy. To ensure high-quality care, systematic reviews (SRs) a...

    Authors: Fangyuan Zhang, Aomei Shen, Yinghui Jin and Wanmin Qiang

    Citation: BMC Complementary and Alternative Medicine 2018 18:236

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  8. Content type: Research article

    Bombax ceiba is used traditionally to treat bone disorders, rheumatism, and joint pain. The aim of the study is to carry out osteogenic activity in-vitro and anti-osteoporotic activity in-vivo of stem bark of B. ...

    Authors: Shashi Chauhan, Aditi Sharma, Navneet Kumar Upadhyay, Gajender Singh, Uma Ranjan Lal and Rohit Goyal

    Citation: BMC Complementary and Alternative Medicine 2018 18:233

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  9. Content type: Research article

    Dendritic cells (DCs) are unique antigen presenting cells (APC) which play a pivotal role in immunotherapy and induction of an effective immune response against tumors. In the present study, 80% ethanol extrac...

    Authors: Shimaa Ibrahim Abdelmenym Mohamed, Ibrahim Jantan, Mohd Azlan Nafiah, Mohamed Ali Seyed and Kok Meng Chan

    Citation: BMC Complementary and Alternative Medicine 2018 18:232

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  10. Content type: Research article

    Lagerstroemia speciosa (L.) Pers. (Family: Lythraceae) is used in traditional medicine in the treatment of diarrhea, diabetes and other diseases. The study was performed to conduct antioxidant, cytotoxic, thrombo...

    Authors: Tasnuva Sharmin, Md. Shahidur Rahman and Habiba Mohammadi

    Citation: BMC Complementary and Alternative Medicine 2018 18:231

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  11. Content type: Research article

    Astragalus membranaceus (Fisch.) Bunge is one of the most widely used traditional Chinese herbal medicines. It is used as immune stimulant, tonic, antioxidant, hepatoprotectant, diuretic, antidiabetic, anticancer...

    Authors: Yizhe Cui, Qiuju Wang, Rui Sun, Li Guo, Mengzhu Wang, Junfeng Jia, Chuang Xu and Rui Wu

    Citation: BMC Complementary and Alternative Medicine 2018 18:230

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  12. Content type: Research article

    The prevalence of complementary medicine use in pregnancy and lactation has been increasingly noted internationally. This systematic review aimed to determine the complementary medicine products (CMPs) used in...

    Authors: Larisa Ariadne Justine Barnes, Lesley Barclay, Kirsten McCaffery and Parisa Aslani

    Citation: BMC Complementary and Alternative Medicine 2018 18:229

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  13. Content type: Research article

    Neonatal jaundice affects at least 481,000 newborns every year. Phototherapy is recommended but it’s effects are limited and adverse reactions can occur. In China, phototherapy combined with Yinzhihuang oral l...

    Authors: Ruo-han Wu, Shuo Feng, Mei Han, Patrina Caldwell, Shi-gang Liu, Jing Zhang and Jian-ping Liu

    Citation: BMC Complementary and Alternative Medicine 2018 18:228

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  14. Content type: Research article

    Although Galanthus nivalis L. (snowdrop) is known for the galanthamine content, used in the treatment of Alzheimer disease, the polyphenolic compounds of Amaryllidaceae species are less studied. Proper understand...

    Authors: Daniela Benedec, Ilioara Oniga, Daniela Hanganu, Ana Maria Gheldiu, Cristina Pușcaș, Radu Silaghi-Dumitrescu, Mihaela Duma, Brîndușa Tiperciuc, Rodica Vârban and Laurian Vlase

    Citation: BMC Complementary and Alternative Medicine 2018 18:226

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  15. Content type: Research article

    The increasing number of multidrug-resistant bacteria and the fact of antibiotic resistance is leading to a continuous need for discovering alternative treatments against infections, e.g. in the case of respir...

    Authors: Kamilla Ács, Viktória L. Balázs, Béla Kocsis, Tímea Bencsik, Andrea Böszörményi and Györgyi Horváth

    Citation: BMC Complementary and Alternative Medicine 2018 18:227

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  16. Content type: Research article

    Chagas Disease caused by Trypanosoma cruzi infection, is one of the most important neglected tropical diseases (NTD), without an effective therapy for the successful parasite eradication or for the blocking of th...

    Authors: Érika Marcela Moreno, Sandra Milena Leal, Elena E. Stashenko and Liliana Torcoroma García

    Citation: BMC Complementary and Alternative Medicine 2018 18:225

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  17. Content type: Research article

    Phyllanthus amarus has been used widely in various traditional medicines to treat swelling, sores, jaundice, inflammatory diseases, kidney disorders, diabetes and viral hepatitis, while its pharmacological and bi...

    Authors: Hemavathy Harikrishnan, Ibrahim Jantan, Md. Areeful Haque and Endang Kumolosasi

    Citation: BMC Complementary and Alternative Medicine 2018 18:224

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  18. Content type: Research article

    Streblus asper is a well-known plant native to Southeast Asia. Different parts of the plant have been traditionally used for various medicinal purposes. However, there is very little scientific evidence reporting...

    Authors: Anchalee Prasansuklab, Atsadang Theerasri, Matthew Payne, Alison T. Ung and Tewin Tencomnao

    Citation: BMC Complementary and Alternative Medicine 2018 18:223

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  19. Content type: Research article

    Medicinal plants represent a source of new drugs for the prevention and treatment of infectious diseases. Dendropanax morbifera Léveille is an economically and medicinally important subtropical tree that has vari...

    Authors: Biruk Tesfaye Birhanu, Jin-Yoon Kim, Md. Akil Hossain, Jae-Won Choi, Sam-Pin Lee and Seung-Chun Park

    Citation: BMC Complementary and Alternative Medicine 2018 18:222

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  20. Content type: Research article

    Endothelial cells are sensitive to changes in both blood components and mechanical stimuli. Endothelial cells may undergo phenotypic changes, such as changes in adhesion protein expression, under different she...

    Authors: Ming Zhang, Jie Sun, Beidong Chen, Yanyang Zhao, Huan Gong, Yun You and Ruomei Qi

    Citation: BMC Complementary and Alternative Medicine 2018 18:220

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  21. Content type: Research article

    Propolis is a natural substance produced by bees and is known to have antimicrobial activity. Our aim was to evaluate the antimicrobial effect of micellar nanocomposites loaded with an ethyl acetate extract of...

    Authors: Isabel Cristina Celerino de Moraes Porto, Dayse Chaves Cardoso de Almeida, Gabriela Vasconcelos Calheiros de Oliveira Costa, Tayná Stéphanie Sampaio Donato, Letícia Moreira Nunes, Ticiano Gomes do Nascimento, José Marcos dos Santos Oliveira, Carolina Batista da Silva, Natanael Barbosa dos Santos, Maria Luísa de Alencar e Silva Leite, Irinaldo Diniz Basílio-Júnior, Camila Braga Dornelas, Pierre Barnabé Escodro, Eduardo Jorge da Silva Fonseca and Regianne Umeko Kamiya

    Citation: BMC Complementary and Alternative Medicine 2018 18:219

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  22. Content type: Research article

    The polysaccharide component of Angelica gigas induces immuno-stimulatory effects on innate immune cells. However, it is unclear whether A. gigas’ adjuvant activity on the immune system can elicit anti-cancer res...

    Authors: Seo Hyun Kim, Sung Won Lee, Hyun Jung Park, Sang Hee Lee, Won Kyun Im, Young Dong Kim, Kyung Hee Kim, Sang Jae Park, Seokmann Hong and Sung Ho Jeon

    Citation: BMC Complementary and Alternative Medicine 2018 18:218

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  23. Content type: Research article

    Histamine is a well-known mediator involved in skin allergic responses through up-regulation of pro-inflammatory cytokines. Antihistamines remain the mainstay of allergy treatment, but they were found limited ...

    Authors: Nurul Atika Razali, Nur Amiza Nazarudin, Kok Song Lai, Faridah Abas and Syahida Ahmad

    Citation: BMC Complementary and Alternative Medicine 2018 18:217

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  24. Content type: Research article

    Ipomoea batatas L. Lam. is a functional food and belongs to family Convolvulaceae. It is used as an antiinflammatory, aphrodisiac, antiasthmatic, anticonvalescent, antitumor, antanemic and antidiabetic agent by l...

    Authors: Muhammad Majid, Bakht Nasir, Syeda Saniya Zahra, Muhammad Rashid Khan, Bushra Mirza and Ihsan-ul Haq

    Citation: BMC Complementary and Alternative Medicine 2018 18:216

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  25. Content type: Research article

    Identifying ornamental plants as new natural antioxidant and antimicrobial sources is always of great importance for the ornamental and horticultural industries.

    Authors: Hosam O. Elansary, Samir A. M. Abdelgaleil, Eman A. Mahmoud, Kowiyou Yessoufou, Khalid Elhindi and Salah El-Hendawy

    Citation: BMC Complementary and Alternative Medicine 2018 18:214

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  26. Content type: Research article

    Jawoongo is an herbal mixture used in traditional medicine to treat skin diseases. This study aimed to investigate whether Jawoongo ameliorates Atopic dermatitis (AD)-like pathology in mice and to understand i...

    Authors: Jin Mo Ku, Se Hyang Hong, Soon Re Kim, Han-Seok Choi, Hyo In Kim, Dong Uk Kim, So Mi Oh, Hye Sook Seo, Tai Young Kim, Yong Cheol Shin, Chunhoo Cheon and Seong-Gyu Ko

    Citation: BMC Complementary and Alternative Medicine 2018 18:215

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  27. Content type: Research article

    Plant derived medicines show significant contributions to mankind in treating infections of pathogenic bacteria. Recently plants are used in pharmaceutical industries for novel drug preparations because to ens...

    Authors: Sunanda Burman, Kuntal Bhattacharya, Devaleena Mukherjee and Goutam Chandra

    Citation: BMC Complementary and Alternative Medicine 2018 18:213

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  28. Content type: Research article

    Exposure to carbon black nanoparticles (CBNPs), a well-known industrial production, promotes pulmonary toxicity through inflammation and oxidative stress. Recent studies show that some polyphenols exert their ...

    Authors: Hung-Te Hsu, Yu-Ting Tseng, Wen-Jhe Wong, Chi-Ming Liu and Yi-Ching Lo

    Citation: BMC Complementary and Alternative Medicine 2018 18:211

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  29. Content type: Research article

    Liuweiwuling tablets (LWWL) are an herbal product that exerts remarkable effects on liver protection and aminotransferase levels, and they have been approved by the Chinese State Food and Drug Administration (...

    Authors: Huimin Liu, Zhenfang Zhang, Huangwanyin Hu, Congen Zhang, Ming Niu, Ruishen Li, Jiabo Wang, Zhaofang Bai and Xiaohe Xiao

    Citation: BMC Complementary and Alternative Medicine 2018 18:212

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  30. Content type: Research article

    Clinacanthus nutans (Burm. f.) Lindau. has traditionally been using in South East Asia countries to manage cancer. However, scientific evidence is generally lacking to support this traditional claim. This study a...

    Authors: Chin Theng Ng, Lai Yen Fong, Jun Jie Tan, Nor Fadilah Rajab, Faridah Abas, Khozirah Shaari, Kok Meng Chan, Fariza Juliana and Yoke Keong Yong

    Citation: BMC Complementary and Alternative Medicine 2018 18:210

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  31. Content type: Research article

    In China, demands for disease prevention and health care and the prevalence of chronic non-communicable diseases have increased. TCM and general hospitals are increasingly utilizing TCM strategies for chronic ...

    Authors: Xiaoqing Fan, Fanli Meng, Dahui Wang, Qing Guo, Zhuoyu Ji, Lei Yang and Atsushi Ogihara

    Citation: BMC Complementary and Alternative Medicine 2018 18:209

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  32. Content type: Research article

    Pimenta racemosa tree has many traditional uses where its leaves are used as herbal tea for treatment of flatulence, gastric disorder, osteoarthritis, colds and fever in addition to its analgesic and anti-inflamm...

    Authors: Fatma Abd-elkader Moharram, Amal Amin Al-Gendy, Siham Mostafa El-Shenawy, Bassant M. Ibrahim and Mohamed A. Zarka

    Citation: BMC Complementary and Alternative Medicine 2018 18:208

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  33. Content type: Study protocol

    Hypertension control remains a major global challenge. The behavioral approaches recommended for blood pressure reduction are stress reduction, increased exercise and healthy dietary habits. Some study finding...

    Authors: Raja Ram Dhungana, Mahesh Kumar Khanal, Suira Joshi, Om Prakash Kalauni, Anu Shakya, Vijay Bhrutel, Savyata Panthi, Ramesh Kumar KC, Binod Ghimire, Achyut Raj Pandey, Bihungum Bista, Binaya Sapkota, Shiva Ram Khatiwoda, Craig Steven McLachlan and Dinesh Neupane

    Citation: BMC Complementary and Alternative Medicine 2018 18:207

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  34. Content type: Research article

    Although alopecia affects the quality of life, its pathogenesis is unknown, because cellular interactions in the hair follicle are complex. Several authors have suggested using herbal medicine to treat alopeci...

    Authors: Jungtae Leem, Wonmo Jung, Yohwan Kim, Bonghyun Kim and Kyuseok Kim

    Citation: BMC Complementary and Alternative Medicine 2018 18:204

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  35. Content type: Research article

    Epithelial-to-mesenchymal transition (EMT) plays an important role in the progression of renal interstitial fibrosis, which finally leads to renal failure. Oleanolic acid (OA), an activator of NF-E2-related fa...

    Authors: Wei-ming He, Jia-qi Yin, Xu-dong Cheng, Xun Lu, Li Ni, Yi Xi, Gui-dong Yin, Guo-yuan Lu, Wei Sun and Ming-gang Wei

    Citation: BMC Complementary and Alternative Medicine 2018 18:205

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  36. Content type: Research article

    We aimed to evaluate the effects of a hydroalcoholic extract of Juglans regia L. leaves on blood glucose level and cardiovascular risk factors in type 2 diabetic patients.

    Authors: Khadijeh Rabiei, Mohammad Ali Ebrahimzadeh, Majid Saeedi, Adele Bahar, Ozra Akha and Zahra Kashi

    Citation: BMC Complementary and Alternative Medicine 2018 18:206

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  37. Content type: Study protocol

    Uncomplicated urinary tract infections (UTI) are common in general practice and usually treated with antibiotics. This contributes to increasing resistance rates of uropathogenic bacteria. A previous trial sho...

    Authors: Kambiz Afshar, Nina Fleischmann, Guido Schmiemann, Jutta Bleidorn, Eva Hummers-Pradier, Tim Friede, Karl Wegscheider, Michael Moore and Ildikó Gágyor

    Citation: BMC Complementary and Alternative Medicine 2018 18:203

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  38. Content type: Research article

    Royal jelly (RJ), the exclusive food for the larva of queen honeybee, is regarded as the novel supplement to promote human health. The function of RJ may be attributed to its major and unique fatty acid, 10-hy...

    Authors: Yuan-Chang Yang, Wing-Ming Chou, Debora Arny Widowati, I-Ping Lin and Chi-Chung Peng

    Citation: BMC Complementary and Alternative Medicine 2018 18:202

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  39. Content type: Research article

    Cancer is one of the most frequently occurring diseases and is the second leading cause of death worldwide. In this study, anthraquinone derivatives (Compounds 1–5) were evaluated for their anti-cancer potenti...

    Authors: Vivek K. Bajpai, Md Badrul Alam, Khong Trong Quan, Hee-Jeong Choi, Hongyan An, Mi-Kyoung Ju, Sang-Han Lee, Yun Suk Huh, Young-Kyu Han and MinKyun Na

    Citation: BMC Complementary and Alternative Medicine 2018 18:200

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  40. Content type: Research article

    Mentha spicata (M. spicata) is a member of Lamiaceae that spreads mainly in the temperate and sub-temperate zones of the world. It is considered as a rich source of essential oils, which is widely used in pharmac...

    Authors: Sanaa K. Bardaweel, Boulanouar Bakchiche, Husam A. ALSalamat, Maria Rezzoug, Abdelaziz Gherib and Guido Flamini

    Citation: BMC Complementary and Alternative Medicine 2018 18:201

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  41. Content type: Research article

    The constant emergence of antibiotic resistant species and the adverse side effects of synthetic drugs are threatening the efficacy of the drugs that are currently in use. This study was aimed at investigating...

    Authors: Refilwe G. Kudumela, Lyndy J. McGaw and Peter Masoko

    Citation: BMC Complementary and Alternative Medicine 2018 18:199

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  42. Content type: Research article

    Evidence suggests that tocotrienols may benefit bone health in osteopenic women. However, their safety in this population has never been investigated. This study was to evaluate the safety of a 12-week supplem...

    Authors: Chwan-Li Shen, Shu Wang, Shengping Yang, Michael D. Tomison, Mehrnaz Abbasi, Lei Hao, Sheyenne Scott, Md Shahjalal Khan, Amanda W. Romero, Carol K. Felton and Huanbiao Mo

    Citation: BMC Complementary and Alternative Medicine 2018 18:198

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  43. Content type: Research article

    One of the molecular mechanisms involved in upper airway-related diseases is epithelial-to-mesenchymal transition (EMT). Olea europaea (OE) has anti-inflammatory properties and thus, great potential to prevent EM...

    Authors: Rabiatul Adawiyah Razali, Nik Ahmad Hafiz Nik Ahmad Eid, Turkambigai Jayaraman, Muhammad Asyrafi Amir Hassan, Nabilah Qistina Azlan, Nur Farhana Ismail, Nur Qisya Afifah Veronica Sainik, Muhammad Dain Yazid, Yogeswaran Lokanathan, Aminuddin Bin Saim and Ruszymah Bt Hj Idrus

    Citation: BMC Complementary and Alternative Medicine 2018 18:197

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  44. Content type: Research article

    Agastache rugosa (Fisch. & C.A.Mey.) Kuntze (Korean mint) is used to treat diverse types of human disorders in traditional medicine. In recent years, its non-fermented leaf extract (ARE) has been shown to possess...

    Authors: Daehyun Shin, Yoonjin Lee, Yu-Hua Huang, Hye-Won Lim, Kyounghee Jang, Dae-Duk Kim and Chang-Jin Lim

    Citation: BMC Complementary and Alternative Medicine 2018 18:196

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  45. Content type: Research article

    Coconut water has been commonly consumed as a beverage for its multiple health benefits while vinegar has been used as common seasoning and a traditional Chinese medicine. The present study investigates the po...

    Authors: Nurul Elyani Mohamad, Swee Keong Yeap, Boon-Kee Beh, Huynh Ky, Kian Lam Lim, Wan Yong Ho, Shaiful Adzni Sharifuddin, Kamariah Long and Noorjahan Banu Alitheen

    Citation: BMC Complementary and Alternative Medicine 2018 18:195

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  46. Content type: Research article

    It is widely accepted the key role of endothelium in the onset of many chronic and acute vascular and cardiovascular diseases.

    Authors: Chiara Bernardini, Augusta Zannoni, Martina Bertocchi, Irvin Tubon, Mercedes Fernandez and Monica Forni

    Citation: BMC Complementary and Alternative Medicine 2018 18:194

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  47. Content type: Research article

    Traditional Chinese medicine (TCM) has been used by Chinese patients and in many other countries worldwide. However, epidemiological reports and prescription patterns on children are few.

    Authors: Hwey-Fang Liang, Yao-Hsu Yang, Pau-Chung Chen, Hsing-Chun Kuo, Chia-Hao Chang, Ying-Hsiang Wang and Kuang-Ming Wu

    Citation: BMC Complementary and Alternative Medicine 2018 18:191

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  48. Content type: Research article

    Presumably, progression of developmental retinal vascular disorders is mainly driven by persistent ischemia/hypoxia. An investigation into vision-threatening retinal ischemia remains important. Our aim was to ...

    Authors: Wen-Haur Chao, Ming-Yi Lai, Hwai-Tzong Pan, Huei-Wen Shiu, Mi-Mi Chen and Hsiao-Ming Chao

    Citation: BMC Complementary and Alternative Medicine 2018 18:193

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  49. Content type: Research article

    The Nucleotide binding and oligomerization domain-like receptorfamily pyrin domain-containing 3 (NLRP3)-inflammasome plays an important role in various diseases, including a variety of kidney diseases. Naringi...

    Authors: Fenqin Chen, Guozhu Wei, Jiao Xu, Xiaoyu Ma and Qiuyue Wang

    Citation: BMC Complementary and Alternative Medicine 2018 18:192

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  50. Content type: Research article

    In contrast to the guidelines of World Health Organization (WHO) and United States-Centers for Disease Control and prevention (US-CDC), the Chinese national guidelines recommend the use of steroids, intravenou...

    Authors: Dangui Zhang, Jieling Chen and William Ba-Thein

    Citation: BMC Complementary and Alternative Medicine 2018 18:190

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