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  1. Content type: Research article

    Skin injury is inevitable in daily life. In recent years, with the increasing morbidity of diseases such as diabetes and metabolic disorders, chronic wounds have become a considerable challenge in clinical pra...

    Authors: Yan Lin, Qiqi Shao, Meng Zhang, Chenyue Lu, Joy Fleming and Songkun Su

    Citation: BMC Complementary and Alternative Medicine 2019 19:175

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  2. Content type: Research article

    The use of essential oils is growing in the United States, but clinician attitudes, experience, and beliefs regarding their use have not previously been studied.

    Authors: Amy C. S. Pearson, Susanne M. Cutshall, W. Michael Hooten, Nancy J. Rodgers, Brent A. Bauer and Anjali Bhagra

    Citation: BMC Complementary and Alternative Medicine 2019 19:174

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  3. Content type: Research article

    Health supplement (HS) products that are available in the Emirate of Dubai (United Arab Emirates; UAE) contain chemicals that may adversely affect human health. This study aimed to investigate the prevalence o...

    Authors: Naseem Mohammed Abdulla, Faisal Aziz, Iain Blair, Michal Grivna, Balazs Adam and Tom Loney

    Citation: BMC Complementary and Alternative Medicine 2019 19:172

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  4. Content type: Research article

    Drug resistance poses a challenge to malaria control measures. This calls for discovery & development of new chemotherapeutic agents. This study therefore was initiated to investigate the antimalarial activity...

    Authors: Desye Misganaw, Ephrem Engidawork and Teshome Nedi

    Citation: BMC Complementary and Alternative Medicine 2019 19:171

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  5. Content type: Research article

    The use of herbal medicine (HM) has become an essential form of treatment and it is more and more common around the world. Little is known about the reasons that drive people to initially use HM or to maintain...

    Authors: Alexandra N. Welz, Agnes Emberger-Klein and Klaus Menrad

    Citation: BMC Complementary and Alternative Medicine 2019 19:170

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  6. Content type: Research article

    Garcinia species contain bioactive compounds such as flavonoids, xanthones, triterpernoids, and benzophenones with antibacterial, antifungal, anti-inflammatory, and antioxidant activities. In addition, many of th...

    Authors: Aziera Adnan, Zeenathul Nazariah Allaudin, Homayoun Hani, Hwei-San Loh, Teng-Jin Khoo, Kang Nee Ting and Rasedee Abdullah

    Citation: BMC Complementary and Alternative Medicine 2019 19:169

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  7. Content type: Research article

    Several immunological pathways, particularly skin inflammation via various pro-inflammatory cytokines have been reported to be involved in the pathogenesis and clinical manifestations of psoriasis. The aim of ...

    Authors: Raksawan Deenonpoe, Pokpong Prayong, Nattakarn Thippamom, Jitlada Meephansan and Kesara Na-Bangchang

    Citation: BMC Complementary and Alternative Medicine 2019 19:168

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  8. Content type: Research article

    Centella asiatica (L.) Urban, known as Indian Pennywort, is a tropical medicinal plant from Apiaceae family native to Southeast Asian countries. It has been widely used as a nerve tonic in Ayuverdic medicine sinc...

    Authors: Norazzila Omar, Yogeswaran Lokanathan, Zainul Rashid Mohd Razi and Ruszymah Bt Haji Idrus

    Citation: BMC Complementary and Alternative Medicine 2019 19:167

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  9. Content type: Research article

    To evaluate the pharmaceutical safety of Myelophil, an ethanol extract of a mixture of Astragali Radix and Salviae Miltiorrhizae Radix, using both acute and repeated toxicological studies.

    Authors: Jin-Yong Joung, Jin-Seok Lee, Jung-Hyo Cho, Dong-Soo Lee and Chang-Gue Son

    Citation: BMC Complementary and Alternative Medicine 2019 19:166

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  10. Content type: Research article

    Rosmarinic acid (RA) is a natural pure compound from herbs belonging to the Lamiaceae family, such as rosemary, sage, basil, and mint. The antioxidant, angiotensin-converting enzyme inhibitory, and vasodilatory e...

    Authors: Mujalin Prasannarong, Vitoon Saengsirisuwan, Juthamard Surapongchai, Jariya Buniam, Natsasi Chukijrungroat and Yupaporn Rattanavichit

    Citation: BMC Complementary and Alternative Medicine 2019 19:165

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  11. Content type: Research article

    Caesalpinia mimosoides, a vegetable consumed in Thailand, has been reported to exhibit in vitro antioxidant properties. The in vivo antioxidant and anti-aging activities have not been investigated. The aim of thi...

    Authors: Panthakarn Rangsinth, Anchalee Prasansuklab, Chatrawee Duangjan, Xiaojie Gu, Krai Meemon, Michael Wink and Tewin Tencomnao

    Citation: BMC Complementary and Alternative Medicine 2019 19:164

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  12. Content type: Research article

    Therapeutic vaccines against cervical cancer remain ineffective. Previously, we demonstrated that blocking the signalling of a cytokine, interleukin 10, at the time of immunisation elicited significantly highe...

    Authors: Xuan Pan, Bowei Ma, Xinchao You, Shu Chen, Jialing Wu, Tianfang Wang, Shelley F. Walton, Jianwei Yuan, Xiaolian Wu, Guoqiang Chen, Yuejian Wang, Guoying Ni and Xiaosong Liu

    Citation: BMC Complementary and Alternative Medicine 2019 19:163

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  13. Content type: Research article

    Baltic amber teething necklaces have been popularized as a safe and natural alternative to conventional or pharmacological medicines for the management of teething pain. However, claims made by retailers regar...

    Authors: Michael D. Nissen, Esther T. L. Lau, Peter J. Cabot and Kathryn J. Steadman

    Citation: BMC Complementary and Alternative Medicine 2019 19:162

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  14. Content type: Research article

    Cervical cancer is the second most prevalent cancer worldwide. Portulaca oleracea L. polysaccharide (POL-P3b) has been found to have enhancing immune and anti-cervical cancer activity by oral administration. Dend...

    Authors: Rui Zhao, Xingyue Shao, Guiyan Jia, Yulan Huang, Zhe Liu, Bocui Song and Jinzuo Hou

    Citation: BMC Complementary and Alternative Medicine 2019 19:161

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  15. Content type: Research article

    Delayed gastric emptying play an important role in the pathology of functional dyspepsia. Owing to their functional attributes in alleviating the gastrointestinal disorders, single or polyherbal formulations h...

    Authors: Ramanaiah Illuri, Sudeep Heggar Venkataramana, David Daguet and Shyamprasad Kodimule

    Citation: BMC Complementary and Alternative Medicine 2019 19:159

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  16. Content type: Research article

    Wumei Pill (WMP), a famous herbal formula, has been widely used to treat digestive system diseases in clinical practice in China for centuries. We have found a correlation between the indications of WMP and th...

    Authors: Yuxiang Wan, Lin Xu, Zeyu Liu, Ming Yang, Xin Jiang, Qiaoli Zhang and Jinchang Huang

    Citation: BMC Complementary and Alternative Medicine 2019 19:158

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  17. Content type: Research article

    Cucurbitacin B is the major bioactive constituent in Trichosanthes cucumerina L. fruits, which the pharmacological properties have been studied for decades particularly an anti-tumor activity. The pharmacokinetic...

    Authors: Natthaphon Hunsakunachai, Nitra Nuengchamnong, Weena Jiratchariyakul, Tanawan Kummalue and Phisit Khemawoot

    Citation: BMC Complementary and Alternative Medicine 2019 19:157

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  18. Content type: Research article

    The traditional Chinese medicine prescription, Qianggan formula have been confirmed to be effective on non-alcoholic steatohepatitis (NASH), however, the underlying molecular mechanisms remain obscure.

    Authors: Mingzhe Zhu, Meng Li, Wenjun Zhou, Yang Yang, Fenghua Li, Li Zhang and Guang Ji

    Citation: BMC Complementary and Alternative Medicine 2019 19:156

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  19. Content type: Research article

    Osteochondral defects mostly occur as a result of trauma or articular degeneration. The poor regenerative ability of articular cartilage remains osteochondral defects are a tricky problem to deal with. The mod...

    Authors: Juntao Zhang, Donglin Zhang, Chaochao Wu, Aifeng Liu, Chao Zhang, Jianjie Jiao and Man Shang

    Citation: BMC Complementary and Alternative Medicine 2019 19:155

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  20. Content type: Research article

    Of over 35 Saudi plants traditionally used to treat liver disorders, majority still lack scientific validations. We therefore, evaluated the anti-oxidative, anti-apoptotic and hepatoprotective potential of Solanu...

    Authors: Mohammad K. Parvez, Mohammed S. Al-Dosari, Ahmed H. Arbab, Perwez Alam, Mansour S. Alsaid and Azmat A. Khan

    Citation: BMC Complementary and Alternative Medicine 2019 19:154

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  21. Content type: Research article

    Rhus trilobata Nutt. (Anacardiaceae) (RHTR) is a plant of Mexico that is traditionally used as an alternative treatment for several types of cancer. However, the phytochemical composition and potential toxicity o...

    Authors: Luis Varela-Rodríguez, Blanca Sánchez-Ramírez, Ivette Stephanie Rodríguez-Reyna, José Juan Ordaz-Ortiz, David Chávez-Flores, Erika Salas-Muñoz, Juan Carlos Osorio-Trujillo, Ernesto Ramos-Martínez and Patricia Talamás-Rohana

    Citation: BMC Complementary and Alternative Medicine 2019 19:153

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  22. Content type: Research article

    The leaves of Gongronema latifolium Benth. have long been recognized traditionally as a remedy for a variety of ailments in Africa. This study was conducted to evaluate the safety profile of the ethanolic extract...

    Authors: Bassel Al-Hindi, Nor Adlin Yusoff, Mariam Ahmad, Item Justin Atangwho, Mohd Zaini Asmawi, Majed Ahmed Al-Mansoub, Yasser Mahfooth Tabana, Idris Bello and Mun Fei Yam

    Citation: BMC Complementary and Alternative Medicine 2019 19:152

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  23. Content type: Research article

    Costunolide, a sesquiterpene lactone extracted from Radix Aucklandiae, has the activity against multiple cancers. However, the effect of costunolide on gastric cancer (GC) have remained to be ambiguous. In this s...

    Authors: Zhanpeng Yan, Tingting Xu, Zhentao An, Ying Hu, Wanzhen Chen, Jinxia Ma, Changle Shao and Fangshi Zhu

    Citation: BMC Complementary and Alternative Medicine 2019 19:151

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  24. Content type: Research article

    Traditional medicine remedies are commonly used for treatment of diverse ailments including bacterial infections. The activity against resistant bacteria and safety of some remedies sold as anti-infective trea...

    Authors: Moses Njutain Ngemenya, Ghogo Gail Rinda Djeukem, Kennedy Dohjinga Nyongbela, Petuel Ndip Ndip Bate, Smith Borakaeyabe Babiaka, Elvis Monya and Rudolf Khundou Kanso

    Citation: BMC Complementary and Alternative Medicine 2019 19:150

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  25. Content type: Research article

    The kidney is an essential organ required by the body to perform several important functions. Nephrotoxicity is one of the most prevailing kidney complications that result from exposure to an extrinsic or intr...

    Authors: Marwa M. Abu-Serie, Noha H. Habashy and Adham M. Maher

    Citation: BMC Complementary and Alternative Medicine 2019 19:149

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  26. Content type: Research article

    Sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson, SBT) is a valuable plant because of its medical and therapeutic potential. Different bioactive compounds in SBT berries are of special interest to various resea...

    Authors: Bartosz Skalski, Bogdan Kontek, Bernadetta Lis, Beata Olas, Łukasz Grabarczyk, Anna Stochmal and Jerzy Żuchowski

    Citation: BMC Complementary and Alternative Medicine 2019 19:148

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  27. Content type: Research article

    Ethanol withdrawal (EtOHW) anxiety is a crucial risk factor for alcoholic relapse. The neuropeptide nociceptin/orphanin FQ (N/OFQ) acts upon its receptor (NOP) to antagonize corticotropin-releasing factor (CRF...

    Authors: Li Bo Li, Young Woo Kim, Yu Hua Wang, Li Bai, Xiao Dong Zhu, Zheng Lin Zhao, Chul Won Lee, Yu Jiao, Tong Wu, Zhen Zhen Cai, Sang Chan Kim, Won G. An, Chae Ha Yang, Guang Cheng Cui and Rong Jie Zhao

    Citation: BMC Complementary and Alternative Medicine 2019 19:147

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  28. Content type: Research article

    There is increasing interest in the pharmaceutical and food industries to substitute synthetic chemicals with naturally occurring compounds possessing bioactive properties. Plants are valuable sources of bioac...

    Authors: Maria Rezzoug, Boulanouar Bakchiche, Abdelaziz Gherib, Ascrizzi Roberta, FlaminiGuido, Özge Kilinçarslan, Ramazan Mammadov and Sanaa K. Bardaweel

    Citation: BMC Complementary and Alternative Medicine 2019 19:146

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  29. Content type: Research article

    Previous research findings support an antimicrobial effect of polyphenols against a variety of pathogens, but there is no evidence of this effect against periodontal pathogens in complex biofilms. The purpose ...

    Authors: María C. Sánchez, Honorato Ribeiro-Vidal, Adelaida Esteban-Fernández, Begoña Bartolomé, Elena Figuero, María V. Moreno-Arribas, Mariano Sanz and David Herrera

    Citation: BMC Complementary and Alternative Medicine 2019 19:145

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  30. Content type: Research article

    Moringa oleifera, also known as horseradish tree or drumstick tree, has strong antioxidant properties. In the present study, we investigated the potential effect of Moringa oleifera stem extract (MOSE) on catarac...

    Authors: Lei Qi, Yu Zhou, Weijie Li, Mali Zheng, Ruisheng Zhong, Xin Jin and Yuan Lin

    Citation: BMC Complementary and Alternative Medicine 2019 19:144

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  31. Content type: Research article

    Constipation, a common health problem, causes discomfort and affects the quality of life. This study intended to evaluate the potential laxative effect of triple fermented barley (Hordeum vulgare L.) extract (FBe...

    Authors: Jong-Min Lim, Young Dae Kim, Chang-Hyun Song, Su-Jin Park, Dong-Chan Park, Hyung-Rae Cho, Go-Woon Jung, Khawaja Muhammad Imran Bashir, Sae Kwang Ku and Jae-Suk Choi

    Citation: BMC Complementary and Alternative Medicine 2019 19:143

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  32. Content type: Research article

    Microbial species in the brine pools of the Red Sea and the brine pool-seawater interfaces are exposed to high temperature, high salinity, low oxygen levels and high concentrations of heavy metals. As adaptati...

    Authors: Luke Esau, Guishan Zhang, Sunil Sagar, Ulrich Stingl, Vladimir B. Bajic and Mandeep Kaur

    Citation: BMC Complementary and Alternative Medicine 2019 19:142

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  33. Content type: Research article

    Antimicrobial resistance (AMR) remains an important global health issue but the gap between AMR and development of new antimicrobials is increasing. Plant extracts may have good activity per se or may be sourc...

    Authors: Ibukun M. Famuyide, Abimbola O. Aro, Folorunso O. Fasina, Jacobus N. Eloff and Lyndy J. McGaw

    Citation: BMC Complementary and Alternative Medicine 2019 19:141

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  34. Content type: Research article

    Cholera is one of the most deadly diarrheal diseases that require new treatments. We investigated the neutralization of cholera toxin by five plant extracts obtained from the Rosaceae family that have been tra...

    Authors: Magdalena Komiazyk, Malgorzata Palczewska, Izabela Sitkiewicz, Slawomir Pikula and Patrick Groves

    Citation: BMC Complementary and Alternative Medicine 2019 19:140

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  35. Content type: Research article

    Several studies have found that caffeic acid (CA), a well-known phytochemical, displays important antioxidant and anti-cancer activities. However, no evidence exists on the protective effect and its mechanisms...

    Authors: Sung-Yong Yang, Min Cheol Pyo, Mi-Hyun Nam and Kwang-Won Lee

    Citation: BMC Complementary and Alternative Medicine 2019 19:139

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  36. Content type: Research article

    Oxymatrine (OM), a quinolizidine alkaloid extracted from a herb Sophorae Flavescentis Radix, has been used to treat liver fibrotic diseases. However, the mechanism of its anti-fibrosis effects is still unclear. T...

    Authors: Li-Ying Song, Yu-Tao Ma, Wei-Jin Fang, Yang He, Jia-Li Wu, Shan-Ru Zuo, Zhen-Zhen Deng, Sheng-Feng Wang and Shi-Kun Liu

    Citation: BMC Complementary and Alternative Medicine 2019 19:138

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  37. Content type: Research article

    The Cree of Eeyou Istchee (James Bay area of northern Quebec) suffer from a high rate of diabetes and its complications partly due to the introduction of the western lifestyle within their culture.

    Authors: Ashleigh D. Downing, Hoda M. Eid, Andrew Tang, Fida Ahmed, Cory S. Harris, Pierre S. Haddad, Timothy Johns, John T. Arnason, Steffany A. L. Bennett and Alain Cuerrier

    Citation: BMC Complementary and Alternative Medicine 2019 19:137

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  38. Content type: Research article

    Tomato fruit (Lycopersicon esculentum Mill.) has been suggested to be useful for the prevention of diabetes. Esculeoside A is the main saponin compounds in tomatoes. This study investigated the hypoglycemic effec...

    Authors: Ziming Yang, Li Zhang, Jinglei Liu, Fenglai Lu, Lei Wang, Yueyuan Chen and Dianpeng Li

    Citation: BMC Complementary and Alternative Medicine 2019 19:136

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  39. Content type: Research article

    Sexual problems are widespread and adversely affect the interpersonal relationships and the quality of life. Currently, synthetic drugs improving sexual function are available, but expenditures for such agents...

    Authors: Yi Zhang, Feixian Zhou and Fahuan Ge

    Citation: BMC Complementary and Alternative Medicine 2019 19:135

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  40. Content type: Research article

    Calotropis gigantea (CG) is a tall and waxy flower that is used as a traditional remedy for fever, indigestion, rheumatism, leprosy, and leukoderma. However, the precise mechanisms of its anticancer effects have ...

    Authors: Jiyon Lee, Hui-Ju Jang, Hyunwoo Chun, Thu-Huyen Pham, Yesol Bak, Jong-Woon Shin, Hang Jin, Yong-In Kim, Hyung Won Ryu, Sei Ryang Oh and Do-Young Yoon

    Citation: BMC Complementary and Alternative Medicine 2019 19:134

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  41. Content type: Research article

    Nigerian Cannabis sativa (hemp) causes male gonadotoxicity by inducing hyperprolactinemia, down-regulation of hypothalamic-pituitary-testicular axis, and oxidative stress. Benin republic hemp has been preferred b...

    Authors: Abdullateef Isiaka Alagbonsi, Luqman Aribidesi Olayaki, Halimat Amin Abdulrahim, Thomson Sijuade Adetona and Gbemileke Tobiloba Akinyemi

    Citation: BMC Complementary and Alternative Medicine 2019 19:132

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  42. Content type: Research article

    The effects of acupuncture on in vitro fertilization (IVF) outcomes remain controversial. And the variation in participant, interventions, outcomes studied, and trial design may relate to the efficacy of adjuv...

    Authors: Zheng-yun Xie, Zhi-hang Peng, Bing Yao, Li Chen, Yan-yun Mu, Jie Cheng, Qian Li, Xi Luo, Peng-yan Yang and You-bing Xia

    Citation: BMC Complementary and Alternative Medicine 2019 19:131

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  43. Content type: Research article

    Angoroside C, cinnamic acid, and harpagoside are bioactive constituents in Scrophularia ningpoensis. Currently, an infrared-assisted extraction (IRAE) method coupled with high-performance liquid chromatography wi...

    Authors: Lina Su, Yinghui Deng, Nianzu Chen, Xiuwen Zhang and Taomin Huang

    Citation: BMC Complementary and Alternative Medicine 2019 19:130

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  44. Content type: Research article

    Green tea has polyphenols like flavonoids and catechins; mainly epigallocatechin-3-gallate (EGCG), epicatechin gallate (ECG), epigallocatechin (EGC) and epicatechin (EC), out of which EGCG is of higher abundan...

    Authors: Ashlesha P. Pandit, Shreyas R. Joshi, Preeti S. Dalal and Vinita C. Patole

    Citation: BMC Complementary and Alternative Medicine 2019 19:129

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  45. Content type: Research article

    Salvia officinalis has been used successfully for the treatment of hot flushes and excessive sweating during menopause. However, modes of actions have not been elucidated conclusively. We explored its pharmacolog...

    Authors: Carsten Tober and Roland Schoop

    Citation: BMC Complementary and Alternative Medicine 2019 19:128

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  46. Content type: Research article

    Xin-Ji-Er-Kang (XJEK) is a Chinese herbal formula, which has been reported to exert effective protection against cardiovascular diseases, including hypertension and myocarditis.

    Authors: Ling Ding, Pan Cheng, Li Wang, Juan Hu, Yong-xue Zhang, Guo-wei Cai, Guang-yao Huang and Shan Gao

    Citation: BMC Complementary and Alternative Medicine 2019 19:127

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  47. Content type: Research article

    Mind-body practices are frequently used by people living with HIV to reduce symptoms and improve wellbeing. These include Tai Chi, Qigong, yoga, meditation, and all types of relaxation. Although there is subst...

    Authors: Maria Pilar Ramirez-Garcia, Marie-Pier Gagnon, Sébastien Colson, José Côté, Jorge Flores-Aranda and Myriam Dupont

    Citation: BMC Complementary and Alternative Medicine 2019 19:125

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