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  1. Content type: Research article

    Breast cancer remains a leading cause of death in women worldwide. Although breast cancer therapies have greatly advanced in recent years, many patients still develop tumour recurrence and metastasis, and even...

    Authors: Siyamak Ebrahimi Nigjeh, Swee Keong Yeap, Norshariza Nordin, Behnam Kamalideghan, Huynh Ky and Rozita Rosli

    Citation: BMC Complementary and Alternative Medicine 2018 18:56

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  2. Content type: Research article

    Ocimum micranthum Willd is a plant used in traditional medicine practiced in the region of the Yucatan peninsula. In particular, it is used for the treatment of cutaneous infections and wound healing, however the...

    Authors: Isabel O. Caamal-Herrera, Leydi M. Carrillo-Cocom, Diana Y. Escalante-Réndiz, Diana Aráiz-Hernández and José A. Azamar-Barrios

    Citation: BMC Complementary and Alternative Medicine 2018 18:55

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  3. Content type: Research article

    Degradation of components of the extracellular matrix such as elastin and collagen by elastase and collagenase accelerates skin aging. Phytochemicals that inhibit the activity of these enzymes can be developed...

    Authors: Tinotenda Shoko, Vinesh J. Maharaj, Dashnie Naidoo, Malefa Tselanyane, Rudzani Nthambeleni, Eric Khorombi and Zeno Apostolides

    Citation: BMC Complementary and Alternative Medicine 2018 18:54

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  4. Content type: Research article

    Breastfeeding is recommended worldwide but not fully practiced. The first week after childbirth is regarded as a critical period for increasing breast milk production. The aim of the study was to investigate w...

    Authors: Shuaishuai Wang, Chi Zhang, Cuishan Li, Daocheng Li, Ping He, Zhaojuan Su, Yanling Li, Yiling Ding and Aiping Lu

    Citation: BMC Complementary and Alternative Medicine 2018 18:53

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  5. Content type: Research article

    Dracaena cinnabari (DC) is a perennial tree that located on the Southern coast of Yemen native to the Socotra Island. This tree produces a deep red resin known as the Dragon’s blood, the Twobrother’s Blood or Dam...

    Authors: Nashwan Abdullah Al-Afifi, Aied Mohammed Alabsi, Marina Mohd Bakri and Anand Ramanathan

    Citation: BMC Complementary and Alternative Medicine 2018 18:50

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  6. Content type: Research article

    In China, Panax notoginseng has been used to treat oxidative stress-related diseases for a long time. Panax notoginseng saponins is an extract from Panax notoginseng Ledeb. Its therapeutic potential is related to...

    Authors: Ming-wei Liu, Rui Wei, Mei-xian Su, Hui Li, Tian-wen Fang and Wei Zhang

    Citation: BMC Complementary and Alternative Medicine 2018 18:51

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  7. Content type: Research article

    This study was to evaluate the effects of herbal compound 861 (Cpd861) on ski-related novel protein N (SnoN) and transforming growth factor-β1 (TGF-β1) /Smad signaling in rats with bile duct ligation (BDL)-ind...

    Authors: Cheng Chi, Xiao-ya Liu, Fei Hou, Xiao-zheng Yu, Chun-yun Li, Li-jian Cui, Rui-xia Liu and Cheng-hong Yin

    Citation: BMC Complementary and Alternative Medicine 2018 18:52

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  8. Content type: Research article

    Betulinic acid (BA) is a natural triterpenoid compound and exhibits a wide range of biological and medicinal properties including anti-inflammatory activity. Therefore, this theoretical investigation is perfor...

    Authors: Mohammad Firoz Khan, Nusrat Nahar, Ridwan Bin Rashid, Akhtaruzzaman Chowdhury and Mohammad A. Rashid

    Citation: BMC Complementary and Alternative Medicine 2018 18:48

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  9. Content type: Research article

    Cisplatin (CP) drug is platinum compounds used for the treatment of various human malignancies. However, adverse outcomes related to CP restrict its usage. Acacia hydaspica is a natural shrub with various pharmac...

    Authors: Tayyaba Afsar, Suhail Razak, Ali Almajwal and Muhammad Rashid Khan

    Citation: BMC Complementary and Alternative Medicine 2018 18:49

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  10. Content type: Research article

    So-ochim-tang-gamibang (SOCG) is a traditional Korean medicine frequently used for depression in the clinical field. In this study, we evaluated the potential genotoxicity of SOCG using three standard batterie...

    Authors: Mi Young Lee, Yang-Chun Park, Mirim Jin, Eunseok Kim, Jeong June Choi and In Chul Jung

    Citation: BMC Complementary and Alternative Medicine 2018 18:47

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  11. Content type: Research article

    Guang-Pheretima, which is originated from Pheretima aspergillum, has been documented in academic Chinese herbal studies for nearly 2000 years for its prominent treating effects of various inflammatory diseases su...

    Authors: Chuanqi Huang, Wei Li, Qiufeng Zhang, Lihong Chen, Weiming Chen, Hongchao Zhang and Yuxin Ni

    Citation: BMC Complementary and Alternative Medicine 2018 18:46

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  12. Content type: Research article

    Most of herbal medicines are used without any standard safety and toxicological trials although common assumption is that these products are nontoxic. However, this assumption is incorrect and dangerous, so to...

    Authors: Wubayehu Kahaliw, Bjorn Hellman and Ephrem Engidawork

    Citation: BMC Complementary and Alternative Medicine 2018 18:45

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  13. Content type: Research article

    Many complementary therapies offer benefits for patients with cancer. Others may be risky for patients due to negative interactions with conventional treatment and adverse effects. Therefore, cancer patients n...

    Authors: Trine Stub, Sara A. Quandt, Thomas A. Arcury, Joanne C. Sandberg and Agnete E. Kristoffersen

    Citation: BMC Complementary and Alternative Medicine 2018 18:44

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  14. Content type: Research article

    Storage lower urinary tract symptoms (LUTS) including overactive bladder (OAB) and urinary incontinence (UI) affect millions of people worldwide, significantly impacting quality of life. Plant based medicines ...

    Authors: Niikee Schoendorfer, Nita Sharp, Tracey Seipel, Alexander G. Schauss and Kiran D. K. Ahuja

    Citation: BMC Complementary and Alternative Medicine 2018 18:42

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  15. Content type: Research article

    On account of deterioration of chronic heart failure (CHF) and extensive exploration of Chinese herbal injections (CHIs), we performed a network meta-analysis to investigate the efficacy of CHIs (Huangqi injec...

    Authors: Kai-Huan Wang, Jia-Rui Wu, Dan Zhang, Xiao-Jiao Duan and Meng-Wei Ni

    Citation: BMC Complementary and Alternative Medicine 2018 18:41

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  16. Content type: Research article

    Parrotiopsis jacquemontiana (Decne) Rehder. is locally used for skin infections and in wound healing. In this study we have evaluated methanol extract of its leaves and derived fractions against the clinical mult...

    Authors: Saima Ali, Muhammad Rashid Khan, Irfanullah, Moniba Sajid and Zartash Zahra

    Citation: BMC Complementary and Alternative Medicine 2018 18:43

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  17. Content type: Research article

    Cold hypersensitivity in the hands and feet (CHHF) is a common symptom in Korea and patients with CHHF complain of coldness in the hands and feet in an environment that is not considered cold by unaffected peo...

    Authors: Kwang-Ho Bae, Ho-Yeon Go, Ki-Hyun Park, Ilkoo Ahn, Youngheum Yoon and Siwoo Lee

    Citation: BMC Complementary and Alternative Medicine 2018 18:40

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  18. Content type: Research article

    Our team has identified 17 Boreal forest species from the traditional pharmacopeia of the Eastern James Bay Cree that presented promising in vitro and in vivo biological activities in the context of type 2 dia...

    Authors: Shilin Li, Sarah Pasquin, Hoda M. Eid, Jean-François Gauchat, Ammar Saleem and Pierre S. Haddad

    Citation: BMC Complementary and Alternative Medicine 2018 18:37

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  19. Content type: Research article

    Despite the remarkable progress in cancer therapy in recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one of the most effective...

    Authors: Victor Kuete, Dominique Ngnintedo, Ghislain W. Fotso, Oğuzhan Karaosmanoğlu, Bonaventure T. Ngadjui, Felix Keumedjio, Samuel O. Yeboah, Kerstin Andrae-Marobela and Hülya Sivas

    Citation: BMC Complementary and Alternative Medicine 2018 18:36

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  20. Content type: Research article

    It has been observed that the various part of Baccaurea ramiflora plant is used in rheumatoid arthritis, cellulitis, abscesses, constipation and injuries. This plant also has anticholinergic, hypolipidemic, hypog...

    Authors: Mst. Luthfun Nesa, S. M. Sajedul Karim, Khairunasa Api, Md. Moklesur Rahman Sarker, Md. Monirul Islam, Asma Kabir, Mithun Kumar Sarker, Kamrun Nahar, Mohammad Asadujjaman and Mohammad Sirajum Munir

    Citation: BMC Complementary and Alternative Medicine 2018 18:35

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  21. Content type: Research article

    Hesperidin is a flavonoid with antioxidant, anti-inflammatory, and immune modulatory activities. Photoaging is a consequence of chronic exposure to the sun and ultraviolet (UV) radiation. This study was design...

    Authors: Hee Jeong Lee, A-Rang Im, Su-Man Kim, Hyung-Sik Kang, Jae Dong Lee and Sungwook Chae

    Citation: BMC Complementary and Alternative Medicine 2018 18:39

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  22. Content type: Research article

    Recent studies have found that plant derived microRNA can cross-kingdom regulate the expression of genes in humans and other mammals, thereby resisting diseases. Can exogenous miRNAs cross the blood-prostate b...

    Authors: Xuan Chen, Ren-zhao Wu, Yong-qiang Zhu, Ze-ming Ren, Ye-ling Tong, Feng Yang and Guan-hai Dai

    Citation: BMC Complementary and Alternative Medicine 2018 18:38

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  23. Content type: Research article

    Skin forms an important part of human innate immune system. Wrinkles, thinning and roughening of skin are some of the symptoms that affect the skin as it ages. Reactive oxygen species induced oxidative stress ...

    Authors: Induja Kalyana Sundaram, Deepika Deeptirekha Sarangi, Vignesh Sundararajan, Shinomol George and Sahabudeen Sheik Mohideen

    Citation: BMC Complementary and Alternative Medicine 2018 18:33

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  24. Content type: Research article

    Sheng-ji Hua-yu(SJHY) formula is one of the most useful Traditional Chinese medicine (TCM) in the treatment of the delayed diabetic wound. However, elucidating the related molecular biological mechanism of how...

    Authors: Le Kuai, Jing-ting Zhang, Yu Deng, Shun Xu, Xun-zhe Xu, Min-feng Wu, Dong-jie Guo, Yu Chen, Ren-jie Wu, Xing-qiang Zhao, Hua Nian, Bin Li and Fu-lun Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:32

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  25. Content type: Research article

    Icariin (ICA), a major ingredient of Epimediumbrevicornum, has various pharmacological activities including central nervous system protective functions such as the improvement of learning and memory function in m...

    Authors: Xiaolong Fu, Shujun Li, Shaoyu Zhou, Qin Wu, Feng Jin and Jingshan Shi

    Citation: BMC Complementary and Alternative Medicine 2018 18:34

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  26. Content type: Research article

    Morinda citrifolia L. that was reported with immunomodulating and cytotoxic effects has been traditionally used to treat multiple illnesses including cancer. An anthraquinone derived from fruits of Morinda citrif...

    Authors: Nadiah Abu, Nur Rizi Zamberi, Swee Keong Yeap, Noraini Nordin, Nurul Elyani Mohamad, Muhammad Firdaus Romli, Nurulfazlina Edayah Rasol, Tamilselvan Subramani, Nor Hadiani Ismail and Noorjahan Banu Alitheen

    Citation: BMC Complementary and Alternative Medicine 2018 18:31

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  27. Content type: Research article

    Because twigs of Cinnamomum cassia (TC) have been reported to exert anti-cancer activity, the mechanistic study for TC’s anti-cancer activity is required. Thus, we elucidated the potential molecular mechanism of ...

    Authors: Gwang Hun Park, Hun Min Song, Su Bin Park, Ho-Jun Son, Yurry Um, Hyun-Seok Kim and Jin Boo Jeong

    Citation: BMC Complementary and Alternative Medicine 2018 18:28

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  28. Content type: Research article

    Different parts including the latex of Ficus racemosa L. has been used as a medicine for wound healing in the Ayurveda and in the indigenous system of medicine in Sri Lanka. This plant has been evaluated for its ...

    Authors: Nisansala Swarnamali Bopage, G. M. Kamal Bandara Gunaherath, Kithsiri Hector Jayawardena, Sushila Chandrani Wijeyaratne, Ajita Mahendra Abeysekera and Seneviratne Somaratne

    Citation: BMC Complementary and Alternative Medicine 2018 18:29

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  29. Content type: Research article

    Natural products obtained from plants can be potent sources for developing a variety of pharmaceutical products. Allium species have been widely studied for their anti-cancer effects and presented promising resul...

    Authors: Ovgu Isbilen, Nahit Rizaner and Ender Volkan

    Citation: BMC Complementary and Alternative Medicine 2018 18:30

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  30. Content type: Research article

    Oxidative stress as well as bacterial and fungal infections are common source of diseases while plants are source of medication for curative or protective purposes. Hence, aim of study was to compare the pharm...

    Authors: Iram Fatima, Sobia Kanwal and Tariq Mahmood

    Citation: BMC Complementary and Alternative Medicine 2018 18:27

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  31. Content type: Research article

    Overweight and obesity are considered major health problems that contribute to increase mortality and quality of life. Both conditions have a high prevalence across the world reaching epidemic numbers. Our aim...

    Authors: Andrea Maia-Landim, Juan M. Ramírez, Carolina Lancho, María S. Poblador and José L. Lancho

    Citation: BMC Complementary and Alternative Medicine 2018 18:26

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  32. Content type: Research article

    Hepatitis is a liver inflammation caused by different agents and remains a public health problem worldwide. Medicinal plants are an important source of new molecules being considered for treatment of this dise...

    Authors: Anne Marie Endougou Effa, Emilie Gantier, Thierry Hennebelle, Vincent Roumy, Céline Rivière, Théophile Dimo, Pierre Kamtchouing, Pierre Desreumaux and Laurent Dubuquoy

    Citation: BMC Complementary and Alternative Medicine 2018 18:24

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  33. Content type: Research article

    Within the intercultural milieu of medical pluralism, a nexus of worldviews espousing distinct explanatory models of illness, our research aims at exploring factors leading to complementary and alternative med...

    Authors: Szilvia Zörgő, György Purebl and Ágnes Zana

    Citation: BMC Complementary and Alternative Medicine 2018 18:25

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  34. Content type: Research article

    Numerous health benefits have been attributed to the Ginkgo biloba leaf extract (GBLE), one of the most extensively used phytopharmaceutical drugs worldwide. Recently, concerns of the safety of the extract have b...

    Authors: Stefano Bonassi, Giulia Prinzi, Palma Lamonaca, Patrizia Russo, Irene Paximadas, Giuseppe Rasoni, Raffaella Rossi, Marzia Ruggi, Salvatore Malandrino, Maria Sánchez-Flores, Vanessa Valdiglesias, Barbara Benassi, Francesca Pacchierotti, Paola Villani, Martina Panatta and Eugenia Cordelli

    Citation: BMC Complementary and Alternative Medicine 2018 18:22

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  35. Content type: Research article

    Gyejibokryeong-hwan (Guizhi Fuling Wan in China), a mixture of five herbal plants, is a well-known treatment for renal diseases including those associated with climacteric syndrome. However, the genotoxicity of G...

    Authors: Mee-Young Lee, Chang-Seob Seo, Hyekyung Ha, Eunsook Park, Ji-Young Kim and Hyeun-Kyoo Shin

    Citation: BMC Complementary and Alternative Medicine 2018 18:21

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  36. Content type: Research article

    Cupressus macrocarpa Hartw and Corymbia citriodora (Hook.) K.D. Hill & L.A.S. Johnson, widely grown in many subtropical areas, are used for commercial purposes, such as in perfumery, cosmetics, and room freshener...

    Authors: Mohamed Z. M. Salem, Hosam O. Elansary, Hayssam M. Ali, Ahmed A. El-Settawy, Mohamed S. Elshikh, Eslam M. Abdel-Salam and Krystyna Skalicka-Woźniak

    Citation: BMC Complementary and Alternative Medicine 2018 18:23

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  37. Content type: Research article

    Pelargonium sidoides (PS) and Coptis chinensis root (CR) have traditionally been used to treat various diseases, including respiratory and gastrointestinal infections, dysmenorrhea, and hepatic disorders. The pre...

    Authors: Sang Mi Park, Byung-Gu Min, Ji Yun Jung, Kyung Hwan Jegal, Chul Won Lee, Kwang Youn Kim, Young Woo Kim, Youn-Woong Choi, Il Je Cho, Sae Kwang Ku and Sang Chan Kim

    Citation: BMC Complementary and Alternative Medicine 2018 18:20

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  38. Content type: Research article

    Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparati...

    Authors: Hiroyuki Oka, Ko Matsudaira, Yuichi Takano, Daichi Kasuya, Masaki Niiya, Juichi Tonosu, Masayoshi Fukushima, Yasushi Oshima, Tomoko Fujii, Sakae Tanaka and Hirohiko Inanami

    Citation: BMC Complementary and Alternative Medicine 2018 18:19

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  39. Content type: Study protocol

    It has been suggested that the antioxidant, anti-inflammatory and hypolipidemic activities of cardamom may improve diabetes. However, the effect of this spice has not been investigated in diabetic subjects. Th...

    Authors: Mohadeseh Aghasi, Shohreh Ghazi-Zahedi, Fariba Koohdani, Fereydoun Siassi, Ensieh Nasli-Esfahani, Ali Keshavarz, Mostafa Qorbani, Hoorieh Khoshamal, Asma Salari-Moghaddam and Gity Sotoudeh

    Citation: BMC Complementary and Alternative Medicine 2018 18:18

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  40. Content type: Research article

    Alpinia galanga (L.) Willd. commonly called as Rasna, Greater galangal or Kulinjan is a medicinally important rhizome used in Indian traditional system of medicine to cure a number of ailments. A. galanga is the ...

    Authors: Anuradha S. Upadhye, Anagha Rajopadhye and Lourelle Dias

    Citation: BMC Complementary and Alternative Medicine 2018 18:16

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  41. Content type: Research article

    Based on clinical medications and related studies, we established a Yang-Gan Jie-Du Sang-Jie (YGJDSJ) herbal formula for hepatocarcinoma treatment. In present study, we evaluated the anti-cancer potential of Y...

    Authors: Bing Hu, Tong Zhang, Hong-Mei An, Jia-Lu Zheng, Xia Yan and Xiao-Wei Huang

    Citation: BMC Complementary and Alternative Medicine 2018 18:17

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  42. Content type: Research article

    Nutmeg is the seed kernel inside the fruit of Myristica fragrans Houtt. (Myristicaceae). It possesses various pharmacological activities but is used in Cameroon only for its flavor in making cakes. The present st...

    Authors: Joachim K. Dzotam, Ingrid Konga Simo, Gabin Bitchagno, Ilhami Celik, Louis P. Sandjo, Pierre Tane and Victor Kuete

    Citation: BMC Complementary and Alternative Medicine 2018 18:15

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  43. Content type: Research article

    Fructose-mediated protein glycation (fructation) has been linked to an increase in diabetic and cardiovascular complications due to over consumption of high-fructose containing diets in recent times. The objec...

    Authors: Hardik Ghelani, Valentina Razmovski-Naumovski, Rajeswara Rao Pragada and Srinivas Nammi

    Citation: BMC Complementary and Alternative Medicine 2018 18:13

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  44. Content type: Case report

    Impairment of cognitive function as well as negative symptom is the major factor causing the decline of a patient’s functioning in chronic stages of schizophrenia. However, until now, there were no definite tr...

    Authors: Seung Sun Rho, Young Sup Woo and Won-Myong Bahk

    Citation: BMC Complementary and Alternative Medicine 2018 18:14

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  45. Content type: Research article

    Inflammation has been implicated in many disorders, including cancer and available therapies elicit adverse effects. Plants of the family Rubiaceae have shown potency against inflammation. The anti-inflammator...

    Authors: Oluwayinka Olufunmilayo Owolabi, Dorcas Bolanle James, Ibrahim Sani, Binda T. Andongma, Opeoluwa O. Fasanya and Barnabas Kure

    Citation: BMC Complementary and Alternative Medicine 2018 18:12

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  46. Content type: Research article

    The highbush blueberry (Vaccinium corymbosum) has a beneficial effect on several aspects of human health. The present study investigated the effects of highbush blueberry proanthocyanidins (PACs) on the virulence...

    Authors: Amel Ben Lagha, Geneviève LeBel and Daniel Grenier

    Citation: BMC Complementary and Alternative Medicine 2018 18:10

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  47. Content type: Research article

    Unhealthy lifestyles are a major factor in the development and exacerbation of many chronic diseases. Improving lifestyles though immersive residential experiences that promote healthy behaviours is a focus of...

    Authors: Dhevaksha Naidoo, Adrian Schembri and Marc Cohen

    Citation: BMC Complementary and Alternative Medicine 2018 18:8

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  48. Content type: Research article

    Behavioral studies demonstrated that the administration of Withania somnifera Dunal roots extract (WSE), prolongs morphine-elicited analgesia and reduces the development of tolerance to the morphine’s analgesic e...

    Authors: Francesca Felicia Caputi, Elio Acquas, Sanjay Kasture, Stefania Ruiu, Sanzio Candeletti and Patrizia Romualdi

    Citation: BMC Complementary and Alternative Medicine 2018 18:9

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  49. Content type: Research article

    Many European citizens are seeking complementary and alternative medicine (CAM). These treatments are regulated very differently in the EU/EFTA countries. This may demonstrate differences in how risk associate...

    Authors: Solveig Wiesener, Anita Salamonsen and Vinjar Fønnebø

    Citation: BMC Complementary and Alternative Medicine 2018 18:11

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