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  1. Content type: Research article

    Terminalia chebula Retz. (Combretaceae) is a traditional herbal medicine that is widely used in the treatment of diabetes, immunodeficiency diseases, and stomach ulcer in Asia. However, the anti-amnesic effect of...

    Authors: Min-Soo Kim, Dong Young Lee, Jun Lee, Hyun Woo Kim, Sang Hyun Sung, Jung-Soo Han and Won Kyung Jeon

    Citation: BMC Complementary and Alternative Medicine 2018 18:136

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  2. Content type: Research article

    Cancer patients often suffer from emotional distress as a result of the oncological process. The purpose of our study was to determine whether practice of Jacobson’s relaxation technique reduced consumption of...

    Authors: Paula Parás-Bravo, Cristina Alonso-Blanco, María Paz-Zulueta, Domingo Palacios-Ceña, Carmen María Sarabia-Cobo, Manuel Herrero-Montes, Ester Boixadera-Planas and César Fernández-de-las-Peñas

    Citation: BMC Complementary and Alternative Medicine 2018 18:139

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  3. Content type: Research article

    Brazilian green propolis is produced by mixing secretions from Africanized honey bees with exudate, mainly from Baccharis dracunculifolia. Brazilian propolis is especially rich in flavonoids and cinammic acid der...

    Authors: Hiroshi Kitamura, Natsuko Saito, Junpei Fujimoto, Ken-ichi Nakashima and Daisuke Fujikura

    Citation: BMC Complementary and Alternative Medicine 2018 18:138

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  4. Content type: Research article

    Solanum aculeastrum fruits are used by some cancer sufferers as a form of alternative treatment. Scientific literature is scarce concerning its anticancer activity, and thus the aim of the study was to assess the...

    Authors: Trevor Burger, Tsholofelo Mokoka, Gerda Fouché, Paul Steenkamp, Vanessa Steenkamp and Werner Cordier

    Citation: BMC Complementary and Alternative Medicine 2018 18:137

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  5. Content type: Research article

    Schistosomiasis is an acute and chronic zoonotic parasitic disease caused by trematode worms. The host inflammatory response to schistosome eggs leads to perioval granulomata formation, mainly in the liver and...

    Authors: Dina M. Metwally, Ebtesam M. Al-Olayan, Mohammad Alanazi, Sanaa B. Alzahrany and Abdelhabib Semlali

    Citation: BMC Complementary and Alternative Medicine 2018 18:135

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  6. Content type: Research article

    Radix Paeoniae Rubra (RPR), a traditional Chinese herb, has anti-inflammatory and immuno-regulatory properties. This study explored the effects of RPR on stimulation of osteoclast differentiation in RAW264.7 c...

    Authors: Huey-En Tzeng, Chun-Hao Tsai, Tin-Yun Ho, Chin-Tung Hsieh, Shen-Chieh Chou, Yi-Ju Lee, Gregory J. Tsay, Po-Hao Huang and Yi-Ying Wu

    Citation: BMC Complementary and Alternative Medicine 2018 18:132

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  7. Content type: Study protocol

    Sinew acupuncture is a new modality of acupuncture in which needles are inserted into acupoints, ashi points or spasm points of sinew and muscles along the meridian sinew pathway. A previous observational stud...

    Authors: Kwok Yin Au, Haiyong Chen, Wing Chung Lam, Chiu On Chong, Andrew Lau, Varut Vardhanabhuti, Kin Cheung Mak, Fei Jiang, Wing Yi Lam, Fung Man Wu, Hiu Ngok Chan, Yan Wah Ng, Bacon Fung-Leung Ng, Eric Tat-Chi Ziea and Lixing Lao

    Citation: BMC Complementary and Alternative Medicine 2018 18:133

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  8. Content type: Research article

    The medicinal orchid Dendrobium moniliforme contains water-soluble polysaccharides, phenanthrenes, bibenzyl derivatives, and polyphenol compounds. This study explored the antioxidant and cytotoxic activities of D...

    Authors: Mukti Ram Paudel, Mukesh Babu Chand, Basant Pant and Bijaya Pant

    Citation: BMC Complementary and Alternative Medicine 2018 18:134

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  9. Content type: Research article

    Previously, we reported that ChondorT showed significant anti-arthritis and anti-inflammatory effects. ChondroT, a new herbal medication, consists of the water extracts of Osterici Radix, Lonicerae Folium, Angeli...

    Authors: Jiwon Jeong, Kiljoon Bae, Sun-Gil Kim, Dongwook Kwak, Young-Joo Moon, Chan-Hun Choi, Young-Ran Kim, Chang-Su Na and Seon-Jong Kim

    Citation: BMC Complementary and Alternative Medicine 2018 18:131

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  10. Content type: Research article

    There is limited research regarding patients’ profiles and consumer attitudes and habits of osteopathy in Spain. The purpose of this study was to profile patients who regularly receive osteopathic care in Spai...

    Authors: Gerard Alvarez Bustins, Pedro-Victor López Plaza and Sonia Roura Carvajal

    Citation: BMC Complementary and Alternative Medicine 2018 18:129

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  11. Content type: Research article

    Houttuynia cordata Thunb. and Phyllanthus emblica Linn. are native plants with medicinal and nutritive significance in Asia. The present study was aimed at evaluating antiproliferative effects on human cancer cel...

    Authors: Piyawan Kumnerdkhonkaen, Somprasong Saenglee, Md. Ali Asgar, Gulsiri Senawong, Kanoknan Khongsukwiwat and Thanaset Senawong

    Citation: BMC Complementary and Alternative Medicine 2018 18:130

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  12. Content type: Research article

    Cancer and inflammation are associated with cachexia. Withania somnifera (W. somnifera) possesses antioxidant and anti-inflammatory potential. We investigated the potential of an aqueous extract of the root of W....

    Authors: Dhaneshree Bestinee Naidoo, Anil Amichund Chuturgoon, Alisa Phulukdaree, Kanive Parashiva Guruprasad, Kapaettu Satyamoorthy and Vikash Sewram

    Citation: BMC Complementary and Alternative Medicine 2018 18:126

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  13. Content type: Research article

    Therapeutic use of leaves of M. oleifera has been evaluated in diabetes because of its possible capacity to decrease blood glucose and lipids concentration after ingestion, as result of the polyphenols content an...

    Authors: A. Villarruel-López, D. A. López-de la Mora, O. D. Vázquez-Paulino, A. G. Puebla-Mora, Ma R. Torres-Vitela, L. A. Guerrero-Quiroz and K. Nuño

    Citation: BMC Complementary and Alternative Medicine 2018 18:127

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  14. Content type: Research article

    Lysimachia christinae Hance is a traditional Chinese medicine with diuretic, detumescent, and detoxifying effects. Our aimed to optimize the extraction protocol to maximize the yield of flavonoids from Lysimachia...

    Authors: Ning-hua Wu, Zhi-qiang Ke, Shan Wu, Xiao-song Yang, Qing-jie Chen, Sheng-tang Huang and Chao Liu

    Citation: BMC Complementary and Alternative Medicine 2018 18:128

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  15. Content type: Research article

    Use of multifunctional drugs with neurotrophic supporting and oxidative stress suppressing activity may be considered a therapeutic strategy to protect or repair cellular damage caused during the progression o...

    Authors: Hyun Ah Lee, Ji Eun Kim, Ji Eun Sung, Woo Bin Yun, Dong Seob Kim, Hee Seob Lee, Jin Tae Hong and Dae Youn Hwang

    Citation: BMC Complementary and Alternative Medicine 2018 18:125

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  16. Content type: Research article

    Patients are free to choose conventional or Korean medicine treatment under the dual medical system in Korea, and the prevalence of patients who choose Korean medicine treatment for whiplash-associated disorde...

    Authors: Nohyeon Kim, Byung-Cheul Shin, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-riong Kim, Eui-Hyoung Hwang, Chan Yung Jung, Diana Ruan and In-Hyuk Ha

    Citation: BMC Complementary and Alternative Medicine 2018 18:124

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  17. Content type: Research article

    Alzheimer’s disease (AD), one of the major causes of dementia, is an overwhelming neurodegenerative disease that particularly affects the brain, leading to memory loss and impairment of language and judgment c...

    Authors: A. S. M. Ali Reza, Mohammad Shahadat Hossain, Sharmin Akhter, Md. Rezanur Rahman, Mst. Samima Nasrin, Md. Josim Uddin, Golam Sadik and A. H. M. Khurshid Alam

    Citation: BMC Complementary and Alternative Medicine 2018 18:123

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  18. Content type: Research article

    Crocin (CRO), chlorogenic acid (CGA), geniposide (GEN), and quercetin (QUE) are all natural compounds with anti-obesity properties, in particular, hypolipidemic effects, which have been widely used for the tre...

    Authors: Ennian Leng, Yuan Xiao, Zhentao Mo, Yiqi Li, Yueyue Zhang, Xiaosi Deng, Min Zhou, Chaochao Zhou, Zengxuan He, Jingyi He, Lu Xiao, Junming Li and Wenna Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:122

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  19. Content type: Research article

    Chinese herbal injections (CHIs) are prepared by extracting and purifying effective substances from herbs (or decoction pieces) using modern scientific techniques and methods. CHIs combined with aspirin + anti...

    Authors: Shi Liu, Jia-Rui Wu, Dan Zhang, Kai-Huan Wang, Bing Zhang, Xiao-Meng Zhang, Di Tan, Xiao-Jiao Duan, Ying-Ying Cui and Xin-Kui Liu

    Citation: BMC Complementary and Alternative Medicine 2018 18:120

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  20. Content type: Research article

    Cucumis sativus L. (cucumber), from the family Cucurbitaceae, is a therapeutic plant with various pharmacological benefits, broadly utilized as a part of complementary medicine (e.g., Unani, Ayurveda, Siddha, and...

    Authors: Raid Al Akeel, Ayesha Mateen, Khalid K. Alharbi, Abdullah A. Alyousef, Hazem M. Al-Mandeel and Rabbani Syed

    Citation: BMC Complementary and Alternative Medicine 2018 18:121

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  21. Content type: Research article

    A Chinese herbal formula, namely Jian-Pi-Yi-Shen (JPYS), has been clinically prescribed for patients with chronic kidney disease associated-anemia, and which can improve the patient’s immunological system. How...

    Authors: Jianping Chen, Amy G. W. Gong, Xiaoyan Liu, Zhonggui Li, Airong Qi, Tina T. X. Dong, Tiegang Yi, Karl W. K. Tsim and Shunmin Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:119

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  22. Content type: Research article

    Traditional, complementary and alternative medicine (TCAM) is seen as a way to provide healthcare in both developed and developing countries across the world. In Cambodia, there is a long tradition of using TC...

    Authors: Hattie Pearson, Tyler Fleming, Pheak Chhoun, Sovannary Tuot, Carinne Brody and Siyan Yi

    Citation: BMC Complementary and Alternative Medicine 2018 18:114

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  23. Content type: Research article

    Among the processes involved in the breast tumor microenvironment, angiogenesis and inflammation play a central role, and the main factors of these processes are the vascular endothelial growth factor (VEGF), ...

    Authors: Jéssica Alessandra-Perini, Jamila Alessandra Perini, Karina Cristina Rodrigues-Baptista, Roberto Soares de Moura, Antonio Palumbo Junior, Thiago Alves dos Santos, Pergentino José Cunha Souza, Luiz Eurico Nasciutti and Daniel Escorsim Machado

    Citation: BMC Complementary and Alternative Medicine 2018 18:116

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  24. Content type: Research article

    Bupleurum yinchowense Shan et Y. Li is widely used to treat depressive and anxiety disorders for hundreds of years in China. Total saikosaponins (TSS) is the major ingredient of Bupleurum yinchowense. A-amino-3-h...

    Authors: Xiuping Sun, Xianglei Li, Ruile Pan, Yanfeng Xu, Qiong Wang and Mingjing Song

    Citation: BMC Complementary and Alternative Medicine 2018 18:117

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  25. Content type: Research article

    Type 2 Diabetes (T2D) is a polygenic disease requiring a multipronged therapeutic approach. In the current scenario, the use of polyherbals is increasing among the diabetics. MD-1, a poly herbal formulation is...

    Authors: Srivani Telapolu, Mangathayaru Kalachavedu, Alan Mathew Punnoose and Dwarakanath Bilikere

    Citation: BMC Complementary and Alternative Medicine 2018 18:113

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  26. Content type: Research article

    We aimed to investigate the effectiveness of two different forms of dry pulsatile cupping in patients with chronic low back pain (cLBP) compared to medication on demand only in a three-armed randomized trial.

    Authors: M. Teut, A. Ullmann, M. Ortiz, G. Rotter, S. Binting, M. Cree, F. Lotz, S. Roll and B. Brinkhaus

    Citation: BMC Complementary and Alternative Medicine 2018 18:115

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  27. Content type: Research article

    Accumulating evidence suggests that Fructus Ligustri Lucidi (FLL) plays a beneficial role in preventing the development of osteoporosis. However, the effects of FLL on estrogen receptor (ER) α and ERβ expressions...

    Authors: Yu-qing Tang, Cheng Li, Xue-jiao Sun, Yi Liu, Xi-ting Wang, Yu-bo Guo, Li-li Wang, Ru-feng Ma, Jian-zhao Niu, Min Fu, Dong-wei Zhang and Yu Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:118

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  28. Content type: Research article

    Influenza infection remains a major health threat for animals and humans which crucially requires effective antiviral remedies. The usage of herbal medications as readily available alternatives for their compa...

    Authors: Parvaneh Mehrbod, Muna A. Abdalla, Emmanuel M. Njoya, Aroke S. Ahmed, Fatemeh Fotouhi, Behrokh Farahmand, Dorcas A. Gado, Mansoureh Tabatabaian, Olubunmi G. Fasanmi, Jacobus N. Eloff, Lyndy J. McGaw and Folorunso O. Fasina

    Citation: BMC Complementary and Alternative Medicine 2018 18:112

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  29. Content type: Research article

    Alzheimer’s disease (AD) is the most common form of dementia and the number of AD patients continues to increase worldwide. Components of the germ layer and bran of Brown rice (BR) help maintain good health an...

    Authors: Michiaki Okuda, Yuki Fujita, Takuya Katsube, Hiromasa Tabata, Katsumi Yoshino, Michio Hashimoto and Hachiro Sugimoto

    Citation: BMC Complementary and Alternative Medicine 2018 18:110

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  30. Content type: Research article

    Nowadays herbal products used in traditional medicine are sold in processed forms and thus morphological authentication is almost impossible. With herbal industry rapidly growing size, consumer safety becomes ...

    Authors: Maslin Osathanunkul, Rossarin Osathanunkul and Panagiotis Madesis

    Citation: BMC Complementary and Alternative Medicine 2018 18:111

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  31. Content type: Research article

    Intentional use of complementary and alternative medicine (CAM) has previously only been researched in small, possibly biased, samples. There seems to be a lack of scientific information regarding healthy indi...

    Authors: Agnete E. Kristoffersen, Trine Stub, Frauke Musial, Vinjar Fønnebø, Ola Lillenes and Arne Johan Norheim

    Citation: BMC Complementary and Alternative Medicine 2018 18:109

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  32. Content type: Research article

    Japanese herbal medicines can be used as alternatives to estrogen therapy and are sometimes prescribed for menopausal syndrome because they have fewer side effects and are associated with better compliance tha...

    Authors: Zeyun Wang, Seiji Kanda, Takaki Shimono, Dambajamts Enkh-Undraa and Toshimasa Nishiyama

    Citation: BMC Complementary and Alternative Medicine 2018 18:107

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  33. Content type: Research article

    Antrodia cinnamomea is an indigenous medicinal mushroom in Taiwan, commonly used for the treatment of cancers and inflammatory disorders. 4-acetylantroquinonol B (4AAQB) is one of the active component isolated fr...

    Authors: Chien-Hsin Chang, Chun-Chieh Hsu, An-Sheng Lee, Shih-Wei Wang, Kung-Tin Lin, Wei-Luen Chang, Hui-Chin Peng, Wen-Chiung Huang and Ching-Hu Chung

    Citation: BMC Complementary and Alternative Medicine 2018 18:108

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  34. Content type: Research article

    Dependence on antipsycotic drugs like aripriprazole (ARI) is increasing at alarming rate, hence, this study was undertaken to support the hypothesis that supplementation of Citrus paradisi (Grapefruit) juice havi...

    Authors: Seema Zargar, Abdul-Rahman A. Al-Majed and Tanveer A. Wani

    Citation: BMC Complementary and Alternative Medicine 2018 18:106

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  35. Content type: Research article

    MicroRNAs(miRNAs)are involved in the initiation and progression of hepatocellular carcinoma. ESC, an extract of Stellerachamaejasme L, had been confirmed as a potential anti-tumor extract of Traditional Chinese M...

    Authors: Xiaoni Liu, Shuang Wang, Jianji Xu, Buxin Kou, Dexi Chen, Yajie Wang and Xiaoxin Zhu

    Citation: BMC Complementary and Alternative Medicine 2018 18:99

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  36. Content type: Research article

    Allium fistulosum (Welsh onion) is a traditional medicinal plant used for the treatment of colds, influenza, abdominal pain, headache, and heart disease. This study evaluated the effects of A. fistulosum ethanoli...

    Authors: Yoon-Young Sung, Dong-Seon Kim, Seung-Hyung Kim and Ho Kyoung Kim

    Citation: BMC Complementary and Alternative Medicine 2018 18:105

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  37. Content type: Research article

    Neuraminidase (NA) is one of the key surface protein of the influenza virus, and has been established as a primary drug target for anti-influenza therapies. This study aimed to screen bioactive herbal extracts...

    Authors: Jiawei Liu, Mian Zu, Kaotan Chen, Li Gao, Huan Min, Weiling Zhuo, Weiwen Chen and Ailin Liu

    Citation: BMC Complementary and Alternative Medicine 2018 18:102

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  38. Content type: Research article

    Apium graveolens L. is a traditional Chinese medicine prescribed as a treatment for hypertension, gout, and diabetes. This study aimed to determine the neuroprotective effects of A. graveolens extract against a P...

    Authors: Pennapa Chonpathompikunlert, Phetcharat Boonruamkaew, Wanida Sukketsiri, Pilaiwanwadee Hutamekalin and Morakot Sroyraya

    Citation: BMC Complementary and Alternative Medicine 2018 18:103

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  39. Content type: Research article

    No animal model studies have been conducted in which the efficacy of herbal compounds has been tested against multidrug-resistant Acinetobacter baumannii infections. Very few antibiotics are available for the tre...

    Authors: Chin-Chuan Tsai, Chi-Shiuan Lin, Chun-Ru Hsu, Chiu-Ming Chang, I-Wei Chang, Li-Wei Lin, Chih-Hsin Hung and Jiun-Ling Wang

    Citation: BMC Complementary and Alternative Medicine 2018 18:96

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  40. Content type: Research article

    To evaluate the efficacy and tolerability of a poly-herbal formulation, Herbagut, for the treatment of gastrointestinal symptoms and its effect on quality of life parameters in patients presenting with self-re...

    Authors: Adrian L. Lopresti, Hemant Gupta and Stephen J. Smith

    Citation: BMC Complementary and Alternative Medicine 2018 18:98

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  41. Content type: Research article

    Lung adenocarcinoma is the most common subtype of Non small cell lung cancer in which the PI3K/Akt cascade is frequently deregulated. The ubiquitous expression of the PI3K and the frequent inactivation of PTEN...

    Authors: Fazeela Mahaboob Begum S.M., Kalai Chitra, Benin Joseph, Raji Sundararajan and Hemalatha S.

    Citation: BMC Complementary and Alternative Medicine 2018 18:104

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  42. Content type: Research article

    Laminaria japonica has frequently been used as a food supplement and drug in traditional oriental medicine. Among the major active constituents responsible for the bioactivities of L. japonica, fucoxanthin (FX) h...

    Authors: Eun Jeong Jang, Sang Chan Kim, Ju-Hee Lee, Jong Rok Lee, Il Kon Kim, Su Youn Baek and Young Woo Kim

    Citation: BMC Complementary and Alternative Medicine 2018 18:97

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  43. Content type: Research article

    Zingiber zerumbet (L.) Smith belongs to the Zingiberaceae family that is widely distributed throughout the tropics, particularly in Southeast Asia. It is locally known as ‘Lempoyang’ and traditionally used to tre...

    Authors: Asmah Hamid, Farah Wahida Ibrahim, Teoh Hooi Ming, Mohd Nazir Nasrom, Norelina Eusoff, Khairana Husain and Mazlyzam Abdul Latif

    Citation: BMC Complementary and Alternative Medicine 2018 18:101

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  44. Content type: Research article

    It is well known that endoplasmic reticulum (ER) stress plays a huge role in development of metabolic diseases. Specially, ER stress-induced cellular dysfunction has a significant involvement in the pathogenes...

    Authors: Hwa Yeon Kim, Ha Na Song, Munkhtugs Davaatseren, Hyun Joo Chang and Hyang Sook Chun

    Citation: BMC Complementary and Alternative Medicine 2018 18:100

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  45. Content type: Research article

    Urtica dioica, Taraxacum officinale, Calea integrifolia and Caesalpinia pulcherrima are widely used all over the world for treatment of different illnesses. In Mexico, these plants are traditionally used to allev...

    Authors: María R. Flores-Ocelotl, Nora H. Rosas-Murrieta, Diego A. Moreno, Verónica Vallejo-Ruiz, Julio Reyes-Leyva, Fabiola Domínguez and Gerardo Santos-López

    Citation: BMC Complementary and Alternative Medicine 2018 18:95

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  46. Content type: Research article

    Sutherlandia frutescens (L.) R. Br is endemic to Southern Africa where it has been traditionally used for cancer and diabetes. In recent times it has been marketed for its reputed (but not proven) anticancer, ant...

    Authors: Siyabulela S. B. N. Ntuli, Wentzel C. A. Gelderblom and David R. Katerere

    Citation: BMC Complementary and Alternative Medicine 2018 18:93

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  47. Content type: Research article

    The use of herbal medicine, as one element of complementary and alternative medicine, is increasing worldwide. Little is known about the reasons for and factors associated with its use. This study derives insi...

    Authors: Alexandra N. Welz, Agnes Emberger-Klein and Klaus Menrad

    Citation: BMC Complementary and Alternative Medicine 2018 18:92

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  48. Content type: Research article

    The anti-tumor activities of Natural compounds and their derivatives are of great interest to pharmaceutical industries. Fisetin is one of prospective natural compounds in this regard but unfortunately with po...

    Authors: Xue Xiao, Juan Zou, Yin Fang, Yibo Meng, Chao Xiao, Jiaxin Fu, Shiyu Liu, Peng Bai and Yuan Yao

    Citation: BMC Complementary and Alternative Medicine 2018 18:91

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  49. Content type: Research article

    Phyllanthus amarus (Schum & Thonn), a plant belonging to the family of Euphorbiaceae is used in Ivorian traditional medicine to treat cardiovascular disorders such as hypertension. However, although this plant ha...

    Authors: Alain N’guessan Yao, Mamadou Kamagaté, Augustin Kouao Amonkan, Philippe Chabert, Fidèle Kpahé, Camille Koffi, Mathieu N’goran Kouamé, Cyril Auger, Séraphin Kati-Coulibaly, Valérie Schini-Kerth and Henri Die-Kakou

    Citation: BMC Complementary and Alternative Medicine 2018 18:94

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