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  1. Puerarin exerts therapeutic effect on osteoporosis due to its inhibitory effect on the formation of osteoclasts. Puerarin is also widely established as an autophagy inhibitor. The study aimed to investigate th...

    Authors: Guoyou Zhang, Yu Wang, Guoke Tang and Yuanzheng Ma

    Citation: BMC Complementary and Alternative Medicine 2019 19:269

    Content type: Research article

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  2. Cancer cachexia is a cancer-induced multifactorial debilitating syndrome directly accounting for 20% of cancer deaths without effective therapeutic approaches. It is extremely urgent to explore effective anti-...

    Authors: Huiquan Liu, Lu Li, Jun Zou, Ting Zhou, Bangyan Wang, Huihui Sun and Shiying Yu

    Citation: BMC Complementary and Alternative Medicine 2019 19:267

    Content type: Research article

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  3. Propolis is a natural bee product with a wide range of biological activities that are related to its chemical composition. The present study investigated the quantification of quercetin (Q) in Ardabil ethanol ...

    Authors: Fariba Asgharpour, Ali Akbar Moghadamnia, Ebrahim Zabihi, Sohrab Kazemi, Amirmorteza Ebrahimzadeh Namvar, Hemmat Gholinia, Mina Motallebnejad and Hamid Reza Nouri

    Citation: BMC Complementary and Alternative Medicine 2019 19:266

    Content type: Research article

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  4. Carica papaya (CP) extract is becoming popular as an unlicensed herbal remedy purported to hasten recovery in dengue infection, mostly based on observations that it may increase platelet counts. This systematic r...

    Authors: Senaka Rajapakse, Nipun Lakshitha de Silva, Praveen Weeratunga, Chaturaka Rodrigo, Chathurani Sigera and Sumadhya Deepika Fernando

    Citation: BMC Complementary and Alternative Medicine 2019 19:265

    Content type: Research article

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  5. Osteoarthritis (OA) is a common degenerative disease of synovial joints caused by inflammation. Acteoside (ACT), a major component and lipase inhibitor from the Chinese tea Ligustrum purpurascens kudingcha, has b...

    Authors: Zhiguang Qiao, Jiaxin Tang, Wen Wu, Jian Tang and Ming Liu

    Citation: BMC Complementary and Alternative Medicine 2019 19:264

    Content type: Research article

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  6. Inflammation is a symptom associated with many diseases. This symptom is treated with steroidal and non-steroidal anti-inflammatory drugs, which can cause severe side effects when used as long-term treatments....

    Authors: Axel Villagómez-Rodríguez, Julia Pérez-Ramos, Ana Laura Esquivel-Campos, Cuauhtémoc Pérez-González, Claudia Angélica Soto-Peredo and Salud Pérez-Gutiérrez

    Citation: BMC Complementary and Alternative Medicine 2019 19:263

    Content type: Research article

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  7. Natural products play a significant role in human health in relation to the prevention and treatment of inflammatory conditions. One of the plants with great medicinal potentials is Diospyros kaki which is mainly...

    Authors: Jieun Choi, Mi Jeong Kim, Richard Komakech, Haiyoung Jung and Youngmin Kang

    Citation: BMC Complementary and Alternative Medicine 2019 19:262

    Content type: Research article

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  8. Our previous study exhibited free radicals scavenging and antioxidant activities of ethanolic and aqueous extracts of Tamarindus indica L. leaves in chronic sodium fluoride poisoning in rats. Tamarindus indica L....

    Authors: Bishnu Prasad Sinha, Souvick Chatterjee, Rinku Buragohain, Indranil Samanta, Siddhartha Narayan Joardar, Prasenjit Mukherjee, Asit Kumar Maji, Partha Das, Tapan Kumar Mandal and Tapas Kumar Sar

    Citation: BMC Complementary and Alternative Medicine 2019 19:261

    Content type: Research article

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  9. Dengue is a mosquito-borne viral infection that has become a major public health concern worldwide. Presently, there is no specific vaccine or treatment available for dengue viral infection.

    Authors: Kavithambigai Ellan, Ravindran Thayan, Jegadeesh Raman, Kazuya I. P. J. Hidari, Norizah Ismail and Vikineswary Sabaratnam

    Citation: BMC Complementary and Alternative Medicine 2019 19:260

    Content type: Research article

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  10. Traditional and complementary medicines (T&CM) are any form of medicine, practice, treatment, product, technology, knowledge system or ceremony outside of conventional medical practice that aims to prevent and...

    Authors: A. Gall, K. Anderson, J. Adams, V. Matthews and G. Garvey

    Citation: BMC Complementary and Alternative Medicine 2019 19:259

    Content type: Research article

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  11. Herbal and traditional medicines (HTM) are widely used in Asian countries. Specific data on prevalent of HTM usage and association with chronic diseases in the Thai population is currently lacking. We examined...

    Authors: Napatt Kanjanahattakij, Pakakrong Kwankhao, Prin Vathesatogkit, Nisakron Thongmung, Yingampa Gleebbua, Piyamitr Sritara and Chagriya Kitiyakara

    Citation: BMC Complementary and Alternative Medicine 2019 19:258

    Content type: Research article

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  12. Clinacanthus nutans extracts have been consumed by the cancer patients with the hope that the extracts can kill cancers more effectively than conventional chemotherapies. Our previous study reported its anti-infl...

    Authors: Ling-Wei Hii, Swee-Hua Erin Lim, Chee-Onn Leong, Swee-Yee Chin, Ngai-Paing Tan, Kok-Song Lai and Chun-Wai Mai

    Citation: BMC Complementary and Alternative Medicine 2019 19:257

    Content type: Research article

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  13. Arisaema jacquemontii is traditionally used in treatment of different diseases. In this study, phytochemical, in vitro biological and chemo-preventive screening of A. jacquemontii was carried out to explore its p...

    Authors: Saira Tabassum, Muhammad Zia, Esperanza J. Carcahe de Blanco, Riffat Batool, Roohi Aslam, Sajid Hussain, Qamar Wali and Muhammad Mudassar Gulzar

    Citation: BMC Complementary and Alternative Medicine 2019 19:256

    Content type: Research article

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  14. Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is characterized by excessive hepatic lipid accumulation. Many studies have suggested that lipid overload is the key initi...

    Authors: Ke Fang, Fan Wu, Guang Chen, Hui Dong, Jingbin Li, Yan Zhao, Lijun Xu, Xin Zou and Fuer Lu

    Citation: BMC Complementary and Alternative Medicine 2019 19:255

    Content type: Research article

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  15. Fumaria species (Fumariacea) has traditionally been used in wound healing in Iranian folk medicine. However, with the discovery of newer agents, its use has faded off into total obscurity. This study explored the...

    Authors: Fatemeh Davoodi-Roodbordeii, Minoo Afshar, Fatemeh Haji Abas Tabrizi, Samira Choopani, Giti Torkaman, Fariborz Moayer and Mona Salimi

    Citation: BMC Complementary and Alternative Medicine 2019 19:254

    Content type: Research article

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  16. General antiviral agents such as oseltamivir are associated with certain adverse effects and the emergence of resistance. This study investigated the phytochemical properties, antiviral activities, and safety ...

    Authors: Won-Young Bae, Hyeong-Yeop Kim, Kyoung-Sook Choi, Kyung Hoon Chang, Young-Ho Hong, Jongsu Eun, Na-Kyoung Lee and Hyun-Dong Paik

    Citation: BMC Complementary and Alternative Medicine 2019 19:253

    Content type: Research article

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  17. Turmeric is commonly used as a dietary treatment for inflammation, but few studies have evaluated the direct effect of turmeric on cartilage. The purpose of this study was to characterize cartilage explants’ i...

    Authors: Wendy Pearson and Laima S. Kott

    Citation: BMC Complementary and Alternative Medicine 2019 19:252

    Content type: Research article

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  18. While traditional, complementary and alternative medicine (TCAM) is gaining increased interest worldwide, the structural factors associated with the usage of TCAM at the social level have not been sufficiently...

    Authors: Jimpei Misawa, Rie Ichikawa, Akiko Shibuya, Yukihiro Maeda, Ichiro Arai, Teruyoshi Hishiki and Yoshiaki Kondo

    Citation: BMC Complementary and Alternative Medicine 2019 19:251

    Content type: Research article

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  19. Parents’ use of complementary health approaches (CHA) for children with autism spectrum disorder (ASD) are common despite the uncertain evidence of its benefit. Parents often adopt CHA due to dissatisfaction w...

    Authors: Jun Jean Ong

    Citation: BMC Complementary and Alternative Medicine 2019 19:250

    Content type: Research article

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  20. Bacteria have developed resistance to most of the current antibiotics. There is evidence suggesting that plant-derived compounds have a potential for interacting with biological processes. One of the plants co...

    Authors: Winnie Mozirandi, Dexter Tagwireyi and Stanley Mukanganyama

    Citation: BMC Complementary and Alternative Medicine 2019 19:249

    Content type: Research article

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  21. With the current concern caused by drug resistant microorganisms, alternatives to traditional antimicrobials are increasingly necessary. Historical holistic treatments involving natural approaches are now of i...

    Authors: Rhegan C. McGregor, Kory A. Parker, Jacob M. Hornby and Leigh C. Latta IV

    Citation: BMC Complementary and Alternative Medicine 2019 19:247

    Content type: Research article

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  22. Cosmos caudatus is an annual plant known for its medicinal value in treating several health conditions, such as high blood pressure, arthritis, and diabetes mellitus. The α-glucosidase inhibitory activity and tot...

    Authors: Wan Ahmad Wan-Nadilah, Muhammad Tayyab Akhtar, Khozirah Shaari, Alfi Khatib, Azizah Abdul Hamid and Muhajir Hamid

    Citation: BMC Complementary and Alternative Medicine 2019 19:245

    Content type: Research article

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  23. Catalpol, a natural iridoid glycoside in Rehmannia glutinosa, can alleviate proteinuria associated with diabetic nephropathy (DN), however, whether catalpol has a protective effect against podocyte injury in DN r...

    Authors: Yan Chen, Qingpu Liu, Zengfu Shan, Yingying Zhao, Meng Li, Baiyan Wang, Xiaoke Zheng and Weisheng Feng

    Citation: BMC Complementary and Alternative Medicine 2019 19:244

    Content type: Research article

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  24. Brown adipocytes are known to promote energy expenditure and limit weight gain to combat obesity. Averrhoa bilimbi, locally called belimbing buluh (DBB), is mainly used as an ethnomedicine in the treatment of met...

    Authors: Wai Kwan Lau, Nur Adelina Ahmad Noruddin, Abdul Hadi Ariffin, Muhd Zulkarnain Mahmud, Mohd Hasnan Mohd Noor, Azimah Amanah, Mohamad Faiz Hamzah and Zainuddin Zafarina

    Citation: BMC Complementary and Alternative Medicine 2019 19:243

    Content type: Research article

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  25. Cyanidin-3-rutinoside (C3R), a naturally occurring anthocyanin, possesses anti-oxidant, anti-hyperglycemic, anti-glycation and cardioprotective properties. However, its mechanisms responsible for anti-hyperlip...

    Authors: Thavaree Thilavech and Sirichai Adisakwattana

    Citation: BMC Complementary and Alternative Medicine 2019 19:242

    Content type: Research article

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  26. Mulberry silkworm larvae (Bombyx mori) are known as the oldest resource of food and traditional medicine. Although silkworm larvae have been reported to treat various chronic diseases, the effect of fermentation ...

    Authors: Hyun-Dong Cho, Hye-Ji Min, Yeong-Seon Won, Hee-Young Ahn, Young-Su Cho and Kwon-Il Seo

    Citation: BMC Complementary and Alternative Medicine 2019 19:241

    Content type: Research article

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  27. Major depression is an important complication in patients with breast cancer, but is an underrecognized and undertreated condition in this population. The Baihe Zhimu Tang (BZ formula) is a traditional Chinese...

    Authors: Hailong Li, Chunyu Wu, Yu Liu, Shuo Zhang and Xiufei Gao

    Citation: BMC Complementary and Alternative Medicine 2019 19:240

    Content type: Research article

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  28. Chronic obstructive pulmonary disease (COPD) is one global disease. Lung function gradually declines. Medication does not fully reverse the airflow limitation. Qigong’s role in COPD rehabilitation has been ass...

    Authors: Hongxuan Tong, Yihua Liu, Yutian Zhu, Boli Zhang and Jingqing Hu

    Citation: BMC Complementary and Alternative Medicine 2019 19:239

    Content type: Research article

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  29. Annonacin, an annonaceous acetogenin isolated from Annona muricata has been reported to be strongly cytotoxic against various cell lines, in vitro. Nevertheless, its effect against in vivo tumor promoting activit...

    Authors: Mohd Rohaizad Md Roduan, Roslida Abd Hamid and Norhafizah Mohtarrudin

    Citation: BMC Complementary and Alternative Medicine 2019 19:238

    Content type: Research article

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  30. Rice husk, a waste material produced during milling, contains numerous phytochemicals that may be sources of cancer chemopreventive agents. Various biological activities of white and colored rice husk have bee...

    Authors: Arpamas Chariyakornkul, Charatda Punvittayagul, Sirinya Taya and Rawiwan Wongpoomchai

    Citation: BMC Complementary and Alternative Medicine 2019 19:237

    Content type: Research article

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  31. Syzygium cumini (L.) Skeels. is one of the very popular traditionally used medicinal plants with numerous pharmacological activities including antioxidant, hypoglycemic and anti-inflammatory. However, actions of

    Authors: Ahad Abdul Rehman, Azra Riaz, Muhammad Arif Asghar, Muhammad Liaquat Raza, Shadab Ahmed and Kamran Khan

    Citation: BMC Complementary and Alternative Medicine 2019 19:236

    Content type: Research article

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  32. Oxyresveratrol is a major bioactive component derived from the heartwood of Artocarpus lacucha. This compound exerts several biological activities, including neuroprotective effects in vitro and in vivo. However,...

    Authors: Dhirarin Junsaeng, Tosapol Anukunwithaya, Phanit Songvut, Boonchoo Sritularak, Kittisak Likhitwitayawuid and Phisit Khemawoot

    Citation: BMC Complementary and Alternative Medicine 2019 19:235

    Content type: Research article

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  33. The neurobiology of persistent pain shares common underlying psychobiology with that of traumatic stress. Modern treatments for traumatic stress often involve bottom-up sensorimotor retraining/exposure therapi...

    Authors: Alison Flehr, Christopher Barton, Jan Coles, Stephen J. Gibson, Gavin W. Lambert, Elisabeth A. Lambert, Arup K. Dhar and John B. Dixon

    Citation: BMC Complementary and Alternative Medicine 2019 19:234

    Content type: Research article

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  34. Resveratrol is reported to inhibit the growth of prostate, which is characteristic of benign prostatic hyperplasia (BPH) condition. However, the mechanism remains unclear. This study aimed to identify the effe...

    Authors: Chao Li, Wan-Li Hu, Meng-Xin Lu and Guan-Fa Xiao

    Citation: BMC Complementary and Alternative Medicine 2019 19:233

    Content type: Research article

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  35. Metabolic syndrome is a non-communicable disease inclusive of risk factors such as central obesity, hypertension, hyperglycaemia and dyslipidaemia. In this present study, we investigated the ability of Pandanus a...

    Authors: Nur Hidayah Reshidan, Suhaila Abd Muid and Norshalizah Mamikutty

    Citation: BMC Complementary and Alternative Medicine 2019 19:232

    Content type: Research article

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  36. In Korea and China, asiasari radix (AR) is widely used as a traditional anti-inflammatory and analgesic agent. After its skin-regenerating and hair loss-preventing activities were identified, several types of ...

    Authors: Kwang-Ha Park, Jeong-Hae Choi, Yeon-Suk Song, Gyoo-Cheon Kim and Jin-Woo Hong

    Citation: BMC Complementary and Alternative Medicine 2019 19:231

    Content type: Research article

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  37. Hyperglycemia and dyslipidemia are classic features of patients with diabetes mellitus (DM). Cordyceps taii, a folk medicinal fungus native to southern China, possesses various pharmacological activities. This st...

    Authors: Ru-Ming Liu, Rong Dai, Yi Luo and Jian-Hui Xiao

    Citation: BMC Complementary and Alternative Medicine 2019 19:230

    Content type: Research article

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  38. Use of complementary and alternative medicine (CAM), including vitamins, minerals, herbals, and other dietary supplements, is widespread in the United States (ranging from 24% in Hispanics to 50% in American I...

    Authors: Srujitha Marupuru, David Rhys Axon and Marion K. Slack

    Citation: BMC Complementary and Alternative Medicine 2019 19:229

    Content type: Research article

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  39. Non-alcoholic fatty liver disease (NAFLD) may increase the sensitivity to liver injury caused by stimulants such as drugs and poisons. The traditional Chinese medicine (TCM) Jiang-Zhi Granule (JZG) has been prove...

    Authors: Lili Yang, Yan Zhou, Haiyan Song and Peiyong Zheng

    Citation: BMC Complementary and Alternative Medicine 2019 19:228

    Content type: Research article

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  40. Oxidative stress is an imbalance between the levels of reactive oxygen species (ROS), reactive nitrogen species (RNS) and endogenous antioxidants. The aetiology and pathogenesis of several oral diseases are at...

    Authors: Ignacio Peralta, Carla Marrassini, María Laura Barreiro Arcos, Graciela Cremaschi, María Rosario Alonso and Claudia Anesini

    Citation: BMC Complementary and Alternative Medicine 2019 19:227

    Content type: Research article

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  41. Six Chinese herb formulas, namely, the Weijing decoction (WJ), the Maxingshigan decoction (MXSG), the Yuebijiabanxia decoction (YBBX), the Qingqihuatan decoction (QQHT), the Dingchuan decoction (DC) and the Sa...

    Authors: Shaonan Liu, Jing Chen, Jinhong Zuo, Jiaqi Lai, Lei Wu and Xinfeng Guo

    Citation: BMC Complementary and Alternative Medicine 2019 19:226

    Content type: Research article

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  42. We aimed to evaluate the global scientific output of research of acupuncture on insomnia and explore the hotspots and frontiers from 1999 to 2018, by using bibliometric methods.

    Authors: Wenya Pei, Rui Peng, Yuan Gu, Xiaohong Zhou and Jingwen Ruan

    Citation: BMC Complementary and Alternative Medicine 2019 19:225

    Content type: Research article

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  43. Commercial herbal medicines (CHMs) marketed as immune boosters are gaining wide popularity in South Africa, in the absence of control and regulatory guidelines. These commercially packaged and labelled herbal ...

    Authors: Mmamosheledi E. Mothibe, Christina P. Kahler-Venter and Elzbieta Osuch

    Citation: BMC Complementary and Alternative Medicine 2019 19:224

    Content type: Research article

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  44. We aimed to compare patients’ and physicians’ safety reporting using data from large acupuncture trials (44,818 patients) and to determine associations between patient characteristics and reporting of adverse ...

    Authors: Thea Schwaneberg, Claudia M. Witt, Stephanie Roll and Daniel Pach

    Citation: BMC Complementary and Alternative Medicine 2019 19:223

    Content type: Research article

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  45. Chronic hepatic diseases are serious problems worldwide, which may lead to the development of fibrosis and eventually cirrhosis. Despite the significant number of people affected by hepatic fibrosis, no effect...

    Authors: Caio Mateus da Silva, Flávio Henrique Caetano, Franco Dani Campos Pereira, Maria Aparecida Marin Morales, Kumiko Koibuchi Sakane and Karen C. M. Moraes

    Citation: BMC Complementary and Alternative Medicine 2019 19:222

    Content type: Research article

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  46. Lichens produce a huge diversity of bioactive compounds with several biological effects. Gyrophoric acid (GA) is found in high concentrations in the common lichen Umbilicaria hirsuta, however evidence for biologi...

    Authors: Michal Goga, Martin Kello, Maria Vilkova, Klaudia Petrova, Martin Backor, Wolfram Adlassnig and Ingeborg Lang

    Citation: BMC Complementary and Alternative Medicine 2019 19:221

    Content type: Research article

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  47. Baeckea frutescens (B. frutescens) of the family Myrtaceae is a plant that has been used in traditional medicine. It is known to have antibacterial, antipyretic and cytoprotective properties. The objective of thi...

    Authors: S. H. Shahruzaman, M. F. Mustafa, S. Ramli, S. Maniam, S. Fakurazi and S. Maniam

    Citation: BMC Complementary and Alternative Medicine 2019 19:220

    Content type: Research article

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  48. Methicillin-resistant Staphylococcus aureus (MRSA) causes serious infections in hospitals. Penthorum chinense Pursh (PCP), employed by the Miao ethnic minority in China, presents antibacterial activities. In this...

    Authors: Bin Ding, Qinchao Ding, Shun Zhang, Zhuo Jin, Zhaolei Wang, Songtao Li and Xiaobing Dou

    Citation: BMC Complementary and Alternative Medicine 2019 19:219

    Content type: Research article

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