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  1. Content type: Research article

    Cnidii Rhizoma is the dried root stem of Cnidium officinale Makino. Cnidii Rhizoma (CR) has been used to treat menstrual irregularity, menstrual pain, and menopause in Korea. However, the effects and mechanisms o...

    Authors: Ka-Yeon Lee, Jae-Hyun Kim, Eun-Young Kim, Mijung Yeom, Hyuk-Sang Jung and Youngjoo Sohn

    Citation: BMC Complementary and Alternative Medicine 2019 19:207

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  2. Content type: Research article

    About 425 million adults had diabetes mellitus globally in 2017. Type 2 diabetes accounts for the enormous majority of diabetes cases and it is gradually growing which is predicted to increase by 48% in 2045. ...

    Authors: Gebretsadkan Hintsa Tekulu, Ephrem Mebrahtu Araya and Hayelom Gebrekirstos Mengesha

    Citation: BMC Complementary and Alternative Medicine 2019 19:206

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  3. Content type: Research article

    Gastric ulcer is one of the most prevalent diseases worldwide. In Iranian folk medicine, Achillea wilhelmsii (AW) is used as a treatment for gastric ulcer. Previous reports also mentioned Antiulcerogenic properti...

    Authors: Mehdi Koushki, Reyhaneh Farrokhi Yekta, Nasrin Amiri-Dashatan, Masoumeh Dadpay and Fatemeh Goshadrou

    Citation: BMC Complementary and Alternative Medicine 2019 19:205

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  4. Content type: Research article

    Metastasis is the main cause of lung cancer death. As a seed of metastasis, circulating tumor cells are an important target for metastasis intervention. The traditional Chinese medicine, Jinfukang, has been cl...

    Authors: Zujun Que, Zhiyi Zhou, Bin Luo, Changsheng Dong, Yi Jiang, Hegen Li and Jianhui Tian

    Citation: BMC Complementary and Alternative Medicine 2019 19:204

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  5. Content type: Research article

    5-Florouracil (5-FU) is a commonly used chemotherapeutic drug for cholangiocarcinoma, whereas it has unsatisfactory effect, and patients often have chemo-resistance to it. The combination of chemotherapeutic a...

    Authors: Zhaoyu Fu, Kexin Ma, Bing Dong, Chongyu Zhao, Chi Che, Chengyong Dong, Rixin Zhang, Haibo Wang, Xiang Wang and Rui Liang

    Citation: BMC Complementary and Alternative Medicine 2019 19:203

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  6. Content type: Research article

    Scientific studies have shown that the potential therapeutic efficacy of curcumin in several diseases is due to its potent antioxidant and anti-inflammatory properties. Consequently, curcumin supplementation s...

    Authors: Tatiane Andreza Lima Silva, Danielle Coutinho Medeiros, Gidyenne Christine Bandeira Silva Medeiros, Rafaela Catherine Silva Cunha Medeiros, Juliany de Souza Araújo, Jason Azevedo Medeiros, Marcela Abbott Galvao Ururahy, Ronaldo Vagner Thomatieli Santos, Radames Maciel Vitor Medeiros, Lucia Leite-Lais and Paulo Moreira Silva Dantas

    Citation: BMC Complementary and Alternative Medicine 2019 19:202

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  7. Content type: Research article

    Self-directed learning is a student-centered approach based on the students’ evaluation about their own learning needs. Self-directed practice is a component of the self-directed learning which focus on achiev...

    Authors: Giandomenico D’Alessandro, Giacomo Consorti and Francesco Cerritelli

    Citation: BMC Complementary and Alternative Medicine 2019 19:201

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  8. Content type: Research article

    Astilbe rivularis L. is an indigenous medicinal plant growing in high altitude of Darjeeling Himalayan region of India and Nepal. The plant rhizome has been used traditionally as medicine by local tribes to treat...

    Authors: Vijeta Rai, Anoop Kumar, Vaskar Das and Shilpi Ghosh

    Citation: BMC Complementary and Alternative Medicine 2019 19:200

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  9. Content type: Research article

    Triphala is an indigenous medical product used for a variety of diseases. This study was conducted to determine the effect of Triphala on antibiotic properties of gentamicin and oxacillin against multi-drug re...

    Authors: Amirthasingam Manoraj, Vasanthi Thevanesam, B. M. R. Bandara, Asela Ekanayake and Veranja Liyanapathirana

    Citation: BMC Complementary and Alternative Medicine 2019 19:199

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  10. Content type: Research article

    Endothelial cell inflammation is a central event in the pathogenesis of numerous cardiovascular diseases, including sepsis and atherosclerosis. Triptolide, a principal bioactive ingredient of Traditional Chine...

    Authors: Chundong Song, Youping Wang, Lin Cui, Fengna Yan and Si Shen

    Citation: BMC Complementary and Alternative Medicine 2019 19:198

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  11. Content type: Research article

    The present study was aimed to evaluate the molecular level anticaries effect of different medicinal plants against Streptococcus mutans (S.mutans) glucosyltransferases (gtf).

    Authors: Kiranmai Mandava, Uma Rajeswari Batchu, Shravya Kakulavaram, Shulamithi Repally, Ishwarya Chennuri, Srinivas Bedarakota and Namratha Sunkara

    Citation: BMC Complementary and Alternative Medicine 2019 19:197

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  12. Content type: Research article

    The rise in use of food supplements based on botanical ingredients (herbal supplements) is depicted as part of a trend empowering consumers to manage their day-to-day health needs, which presupposes access to ...

    Authors: Matthew Peacock, Mihaela Badea, Flavia Bruno, Lada Timotijevic, Martina Laccisaglia, Charo Hodgkins, Monique Raats and Bernadette Egan

    Citation: BMC Complementary and Alternative Medicine 2019 19:196

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  13. Content type: Research article

    Probiotics have been reported to be the active component used in the treatment of many functional gastrointestinal symptoms and syndromes. Lactobacillus and yeast culture are extensively used in probiotic supplem...

    Authors: Ki-Bae Hong, Hyeyoung Seo, Joong-su Lee and Yooheon Park

    Citation: BMC Complementary and Alternative Medicine 2019 19:195

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  14. Content type: Research article

    Infertility is considered one of the global public health problems and during human history, it is also considered one of the unsolved problems of the continuous human race. This study aimed to collect and doc...

    Authors: Nidal Jaradat and Abdel Naser Zaid

    Citation: BMC Complementary and Alternative Medicine 2019 19:194

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  15. Content type: Research article

    Wenshen Jianpi recipe (WSJPR), a blended traditional Chinese medicine, is considered to have the possible beneficial effect on the progression of diabetic nephropathy (DN). This present study was designed to e...

    Authors: Xiaodan Cao, Renxiong Wei, Jun Zhou, Xiaoxia Zhang, Wenbo Gong, Tinglong Jin and Xiabo Chen

    Citation: BMC Complementary and Alternative Medicine 2019 19:193

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  16. Content type: Research article

    Acute postoperative pain remains a major clinical problem that affects patient recovery. Distal acupoint and peri-incisional stimulation are both used for relieving acute postoperative pain in hospital. Our ob...

    Authors: Juan Zhu, Qian Xu, Rong Zou, Wenzhong Wu, Xiaoqiu Wang, Yanyi Wang, Fangbing Ji, Zhen Zheng and Man Zheng

    Citation: BMC Complementary and Alternative Medicine 2019 19:192

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  17. Content type: Research article

    Wnt/β-catenin signaling pathway is closely related to osteoarthritis. In our preliminary study, β-catenin conditional activation (cAct) mice that specifically over-express β-catenin gene in cartilage chondrocy...

    Authors: Wan-qing Xie, Yong-jian Zhao, Feng Li, Bing Shu, Shu-ru Lin, Li Sun, Yong-jun Wang and Hong-xin Zheng

    Citation: BMC Complementary and Alternative Medicine 2019 19:191

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  18. Content type: Research article

    While yoga is increasingly used for health purposes, its safety has been questioned. The aim of this cross-sectional survey was to analyze yoga-associated adverse effects and their correlates.

    Authors: Holger Cramer, Daniela Quinker, Dania Schumann, Jon Wardle, Gustav Dobos and Romy Lauche

    Citation: BMC Complementary and Alternative Medicine 2019 19:190

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  19. Content type: Research article

    The Atlantic Forest biome extends along the entire Brazilian coast and is home to approximately 20,000 plant species, many of which are endemic; it is considered one of the hotspot regions of the planet. Sever...

    Authors: Ayla das Chagas Almeida, Lais Azevedo Rodrigues, Graziela dos Santos Paulino, Ananda Pereira Aguilar, Alisson Andrade Almeida, Sukarno Olavo Ferreira, Geraldo Célio Brandão, João Paulo Viana Leite and Andréa de Oliveira Barros Ribon

    Citation: BMC Complementary and Alternative Medicine 2019 19:189

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  20. Content type: Research article

    Apiole was isolated from the leaves of various plants and vegetables and has been demonstrated to inhibit human colon cancer cell (COLO 205 cells) growth through induction of G0/G1 cell cycle arrest and apopto...

    Authors: Kuan-Hsun Wu, Wen-Jui Lee, Tzu-Chun Cheng, Hui-Wen Chang, Li-Ching Chen, Chia-Chang Chen, Hsiu-Man Lien, Teng-Nan Lin and Yuan-Soon Ho

    Citation: BMC Complementary and Alternative Medicine 2019 19:188

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  21. Content type: Research article

    One of the most important ways to cure hydatid cysts is surgery. Today, available chemical drugs have shown severe complications during hydatid cyst surgery. Here we investigated theefficacy and safety of Curcuma...

    Authors: Hossein Mahmoudvand, Mahbobeh Pakravanan, Mohammad Reza Aflatoonian, Amal Khudair Khalaf, Massumeh Niazi, Seyyed Reza Mirbadie, Amir Tavakoli Kareshk and Mehrdad Khatami

    Citation: BMC Complementary and Alternative Medicine 2019 19:187

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  22. Content type: Research article

    Oxidative stress and the inflammatory process are involved in ischemia–reperfusion (I/R) injury. Juglans mollis has been reported as having antioxidant activity, which could attenuate the damage caused by I/R. We...

    Authors: Jonathan Perez-Meseguer, Liliana Torres-González, Jorge Aurelio Gutiérrez-González, Gabriela Alarcón-Galván, Homero Zapata-Chavira, Noemi Waksman-de Torres, Diana Patricia Moreno-Peña, Linda Elsa Muñoz-Espinosa and Paula Cordero-Pérez

    Citation: BMC Complementary and Alternative Medicine 2019 19:186

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  23. Content type: Research article

    Honey has been increasingly recognized as a potential therapeutic agent for treatment of wound infections. There is an urgent need for assessment and evaluation of the antibacterial properties against wound pa...

    Authors: Muhammad Barkaat Hussain, Yasser Mahmoud Kamel, Zia Ullah, Asif Ahmad Mohamad Jiman-Fatani and Ansar Shafiq Ahmad

    Citation: BMC Complementary and Alternative Medicine 2019 19:185

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  24. Content type: Research article

    Bitter gourd (Momordica charantia) has attracted the focus of researchers owing to its excellent anti-diabetic action. The beneficial effect of Momordica charantia on heart has been reported by in vitro and in vi...

    Authors: Muhammad Farooq Khan, Nael Abutaha, Fahd A. Nasr, Ali S. Alqahtani, Omar M. Noman and Mohammad A. M. Wadaan

    Citation: BMC Complementary and Alternative Medicine 2019 19:184

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  25. Content type: Research article

    Cylicodiscus gabunensis Harms (Family Leguminosae) (CG) is an African medicinal plant used as a treatment of various ailments including malaria, liver diseases, and gastrointestinal disturbances. Its extracts sho...

    Authors: Omar Aldulaimi, Falko Drijfhout, Fidelia I. Uche, Paul Horrocks and Wen-Wu Li

    Citation: BMC Complementary and Alternative Medicine 2019 19:183

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  26. Content type: Research article

    Increase oxidative trauma is the main cause behind Cisplatin (CP) induced cardiotoxicity which restricts its clinical application as anti-neoplastic prescription. Acacia hydaspica is a natural shrub with diverse ...

    Authors: Tayyaba Afsar, Suhail Razak, Ali Almajwal, Maria Shabbir and Muhammad Rashid Khan

    Citation: BMC Complementary and Alternative Medicine 2019 19:182

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  27. Content type: Research article

    Study of phytochemicals and pharmacological properties of bryophytes has been neglected for a long time because of the three main reasons i.e. (i) difficulty in collection in large amount for analysis; (ii) th...

    Authors: Sumira Mukhia, Palash Mandal, D. K. Singh and Devendra Singh

    Citation: BMC Complementary and Alternative Medicine 2019 19:181

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  28. Content type: Research article

    Fruit, bark and leaves of Zanthoxylum armatum DC are popular remedies for gastrointestinal, cardiovascular and respiratory disorders in the subcontinent traditional practices. The aim of the study was to individu...

    Authors: Fiaz Alam and Abdul Jabbar Shah

    Citation: BMC Complementary and Alternative Medicine 2019 19:180

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  29. Content type: Research article

    Community-dwelling persons with dementia commonly use dietary supplements (DS), often without receiving help with the administration. Patient safety is a concern, as DS-drug interactions and adverse events are...

    Authors: Hilde Risvoll, Frauke Musial, Kjell H. Halvorsen, Trude Giverhaug and Marit Waaseth

    Citation: BMC Complementary and Alternative Medicine 2019 19:179

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  30. Content type: Research article

    To evaluate the effectiveness and safety of HuoXueHuaYu (HXHY) therapy in treating nonalcoholic fatty liver disease (NAFLD) through a systematic review and meta-analysis.

    Authors: Yunfei Cai, Qiuer Liang, Weihao Chen, Minghao Chen, Ruixue Chen, Yun Zhang, Ya Xiao and Liguo Chen

    Citation: BMC Complementary and Alternative Medicine 2019 19:178

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  31. Content type: Research article

    Quercus gall extracts’ ability to kill pathogens in vitro and even removal of chronic drug-resistant infections has been reported by several studies. The current investigation is focused on the action of extracts...

    Authors: Akhter Ahmed Ahmed and Fraidoon Abdulqadir Salih

    Citation: BMC Complementary and Alternative Medicine 2019 19:177

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  32. Content type: Research article

    Snake venoms contain various bioactive constituents which possess potential therapeutic effects. The aim of this work was to investigate the effect of the extract from Agkistrodon halys venom on lipopolysaccharid...

    Authors: Quan-Hai Wang, Wei Li, Yu-Xin Jiang, Xiao-Hua Lu and Guo-Guang Wang

    Citation: BMC Complementary and Alternative Medicine 2019 19:176

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  33. Content type: Research article

    Skin injury is inevitable in daily life. In recent years, with the increasing morbidity of diseases such as diabetes and metabolic disorders, chronic wounds have become a considerable challenge in clinical pra...

    Authors: Yan Lin, Qiqi Shao, Meng Zhang, Chenyue Lu, Joy Fleming and Songkun Su

    Citation: BMC Complementary and Alternative Medicine 2019 19:175

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  34. Content type: Research article

    The use of essential oils is growing in the United States, but clinician attitudes, experience, and beliefs regarding their use have not previously been studied.

    Authors: Amy C. S. Pearson, Susanne M. Cutshall, W. Michael Hooten, Nancy J. Rodgers, Brent A. Bauer and Anjali Bhagra

    Citation: BMC Complementary and Alternative Medicine 2019 19:174

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  35. Content type: Research article

    Health supplement (HS) products that are available in the Emirate of Dubai (United Arab Emirates; UAE) contain chemicals that may adversely affect human health. This study aimed to investigate the prevalence o...

    Authors: Naseem Mohammed Abdulla, Faisal Aziz, Iain Blair, Michal Grivna, Balazs Adam and Tom Loney

    Citation: BMC Complementary and Alternative Medicine 2019 19:172

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  36. Content type: Research article

    Drug resistance poses a challenge to malaria control measures. This calls for discovery & development of new chemotherapeutic agents. This study therefore was initiated to investigate the antimalarial activity...

    Authors: Desye Misganaw, Ephrem Engidawork and Teshome Nedi

    Citation: BMC Complementary and Alternative Medicine 2019 19:171

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  37. Content type: Research article

    The use of herbal medicine (HM) has become an essential form of treatment and it is more and more common around the world. Little is known about the reasons that drive people to initially use HM or to maintain...

    Authors: Alexandra N. Welz, Agnes Emberger-Klein and Klaus Menrad

    Citation: BMC Complementary and Alternative Medicine 2019 19:170

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  38. Content type: Research article

    Garcinia species contain bioactive compounds such as flavonoids, xanthones, triterpernoids, and benzophenones with antibacterial, antifungal, anti-inflammatory, and antioxidant activities. In addition, many of th...

    Authors: Aziera Adnan, Zeenathul Nazariah Allaudin, Homayoun Hani, Hwei-San Loh, Teng-Jin Khoo, Kang Nee Ting and Rasedee Abdullah

    Citation: BMC Complementary and Alternative Medicine 2019 19:169

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  39. Content type: Research article

    Several immunological pathways, particularly skin inflammation via various pro-inflammatory cytokines have been reported to be involved in the pathogenesis and clinical manifestations of psoriasis. The aim of ...

    Authors: Raksawan Deenonpoe, Pokpong Prayong, Nattakarn Thippamom, Jitlada Meephansan and Kesara Na-Bangchang

    Citation: BMC Complementary and Alternative Medicine 2019 19:168

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  40. Content type: Research article

    Centella asiatica (L.) Urban, known as Indian Pennywort, is a tropical medicinal plant from Apiaceae family native to Southeast Asian countries. It has been widely used as a nerve tonic in Ayuverdic medicine sinc...

    Authors: Norazzila Omar, Yogeswaran Lokanathan, Zainul Rashid Mohd Razi and Ruszymah Bt Haji Idrus

    Citation: BMC Complementary and Alternative Medicine 2019 19:167

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  41. Content type: Research article

    To evaluate the pharmaceutical safety of Myelophil, an ethanol extract of a mixture of Astragali Radix and Salviae Miltiorrhizae Radix, using both acute and repeated toxicological studies.

    Authors: Jin-Yong Joung, Jin-Seok Lee, Jung-Hyo Cho, Dong-Soo Lee and Chang-Gue Son

    Citation: BMC Complementary and Alternative Medicine 2019 19:166

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  42. Content type: Research article

    Rosmarinic acid (RA) is a natural pure compound from herbs belonging to the Lamiaceae family, such as rosemary, sage, basil, and mint. The antioxidant, angiotensin-converting enzyme inhibitory, and vasodilatory e...

    Authors: Mujalin Prasannarong, Vitoon Saengsirisuwan, Juthamard Surapongchai, Jariya Buniam, Natsasi Chukijrungroat and Yupaporn Rattanavichit

    Citation: BMC Complementary and Alternative Medicine 2019 19:165

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  43. Content type: Research article

    Caesalpinia mimosoides, a vegetable consumed in Thailand, has been reported to exhibit in vitro antioxidant properties. The in vivo antioxidant and anti-aging activities have not been investigated. The aim of thi...

    Authors: Panthakarn Rangsinth, Anchalee Prasansuklab, Chatrawee Duangjan, Xiaojie Gu, Krai Meemon, Michael Wink and Tewin Tencomnao

    Citation: BMC Complementary and Alternative Medicine 2019 19:164

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  44. Content type: Research article

    Therapeutic vaccines against cervical cancer remain ineffective. Previously, we demonstrated that blocking the signalling of a cytokine, interleukin 10, at the time of immunisation elicited significantly highe...

    Authors: Xuan Pan, Bowei Ma, Xinchao You, Shu Chen, Jialing Wu, Tianfang Wang, Shelley F. Walton, Jianwei Yuan, Xiaolian Wu, Guoqiang Chen, Yuejian Wang, Guoying Ni and Xiaosong Liu

    Citation: BMC Complementary and Alternative Medicine 2019 19:163

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  45. Content type: Research article

    Baltic amber teething necklaces have been popularized as a safe and natural alternative to conventional or pharmacological medicines for the management of teething pain. However, claims made by retailers regar...

    Authors: Michael D. Nissen, Esther T. L. Lau, Peter J. Cabot and Kathryn J. Steadman

    Citation: BMC Complementary and Alternative Medicine 2019 19:162

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  46. Content type: Research article

    Cervical cancer is the second most prevalent cancer worldwide. Portulaca oleracea L. polysaccharide (POL-P3b) has been found to have enhancing immune and anti-cervical cancer activity by oral administration. Dend...

    Authors: Rui Zhao, Xingyue Shao, Guiyan Jia, Yulan Huang, Zhe Liu, Bocui Song and Jinzuo Hou

    Citation: BMC Complementary and Alternative Medicine 2019 19:161

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  47. Content type: Research article

    Delayed gastric emptying play an important role in the pathology of functional dyspepsia. Owing to their functional attributes in alleviating the gastrointestinal disorders, single or polyherbal formulations h...

    Authors: Ramanaiah Illuri, Sudeep Heggar Venkataramana, David Daguet and Shyamprasad Kodimule

    Citation: BMC Complementary and Alternative Medicine 2019 19:159

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  48. Content type: Research article

    Wumei Pill (WMP), a famous herbal formula, has been widely used to treat digestive system diseases in clinical practice in China for centuries. We have found a correlation between the indications of WMP and th...

    Authors: Yuxiang Wan, Lin Xu, Zeyu Liu, Ming Yang, Xin Jiang, Qiaoli Zhang and Jinchang Huang

    Citation: BMC Complementary and Alternative Medicine 2019 19:158

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