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Fig. 7 | BMC Complementary Medicine and Therapies

Fig. 7

From: Neuroprotective effect of acetoxypachydiol against oxidative stress through activation of the Keap1-Nrf2/HO-1 pathway

Fig. 7

The mechanisms of Nrf2 activation by APHD. APHD interferes with the interplay between Keap1 (Kelch-like ECH-associated protein 1) and Nrf2 (NFE2-related factor 2) through binding to Kelch domain’s active pocket. Keap1 contains five domains: NTR (amino terminal region), BTB (broadcomplex/tramtrack/bric-a-brac), IVR (intervening region), Kelch (kelch domain of Nrf2) / DGR (double glycine repeat) and CTR (C-terminal region). APHD bound to the SER363 residue in the Kelch domain’s active pocket to exert the antioxidant effect

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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