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Table 6 The underlying diseases of the patients with DIILD

From: Analysis of drug-induced interstitial lung disease caused by herbal medicine using the Japanese Adverse Drug Event Report database

Crude drug component

Underlying disease

n (%)

Scutellariae radix (SR)

Hypertension

160 (11.29)

 

Constipation

81 (5.72)

 

Obesity

65 (4.59)

 

Hyperlipidemia

59 (4.16)

 

Diabetes

35 (2.47)

 

Asthma

29 (2.05)

 

Alcohol intake

28 (1.98)

 

Dyslipidemia

24 (1.69)

 

Benign prostatic hypertrophy

22 (1.55)

 

Atopic dermatitis

21 (1.48)

 

Insomnia

21 (1.48)

 

Others

872 (61.54)

Bupleuri radix (BR)

Hypertension

161 (8.81)

 

Dementia

107 (5.86)

 

Alzheimer’s disease

64 (3.50)

 

Insomnia

51 (2.79)

 

Constipation

48 (2.63)

 

Depression

38 (2.08)

 

Menopausal symptoms

37 (2.03)

 

Atrial fibrillation

33 (1.81)

 

Hyperlipidemia

33 (1.81)

 

Diabetes

31 (1.70)

 

Cerebral infarction

29 (1.59)

 

Others

1195 (65.41)

Pinelliae tuber (PT)

Hypertension

87 (8.42)

 

Gastro esophageal reflux disease

28 (2.71)

 

Asthma

23 (2.23)

 

Constipation

23 (2.23)

 

Hyperlipidemia

22 (2.13)

 

Insomnia

22 (2.13)

 

Nasopharyngitis

22 (2.13)

 

Allergic rhinitis

18 (1.74)

 

Bronchitis

16 (1.55)

 

Diabetes

16 (1.55)

 

Atrial fibrillation

15 (1.45)

 

Alcohol intake

14 (1.36)

 

Gastritis

14 (1.36)

 

Osteoporosis

12 (1.16)

 

Upper respiratory tract infection

12 (1.16)

 

Chronic gastritis

11 (1.07)

 

Poor appetite

11 (1.07)

 

Others

667 (64.57)

SR_BR

Hemorrhoid

60 (15.04)

 

Hypertension

33 (8.27)

 

Constipation

30 (7.52)

 

Hyperlipidemia

15 (3.76)

 

Gastro esophageal reflux disease

14 (3.51)

 

Insomnia

7 (1.75)

 

Acne

6 (1.50)

 

Anxiety disorder

6 (1.50)

 

Dyslipidemia

6 (1.50)

 

Menopausal symptoms

6 (1.50)

 

Asthma

5 (1.25)

 

Hyperuricemia

5 (1.25)

 

Osteoarthritis

5 (1.25)

 

Others

201 (50.38)

SR_PT

Hypertension

33 (9.19)

 

Periarthritis

21 (5.85)

 

Gastro esophageal reflux disease

14 (3.90)

 

Colonic cancer

9 (2.51)

 

Stomatitis

8 (2.23)

 

Diarrhea

7 (1.95)

 

Hyperlipidemia

7 (1.95)

 

Non-small cell lung cancer

7 (1.95)

 

Dyslipidemia

6 (1.67)

 

Benign prostatic hypertrophy

5 (1.39)

 

Diabetes

5 (1.39)

 

Insomnia

5 (1.39)

 

Liver metastasis

5 (1.39)

 

Lung metastasis

5 (1.39)

 

Rectal cancer

5 (1.39)

 

Others

217 (60.45)

 SR_BR_PT

Hypertension

110 (8.46)

 

Diabetes

40 (3.08)

 

Depression

33 (2.54)

 

Subdural hematoma

33 (2.54)

 

Hyperlipidemia

28 (2.15)

 

Insomnia

21 (1.62)

 

Dizziness

20 (1.54)

 

Sudden sensorineural hearing loss

19 (1.46)

 

Asthma

18 (1.39)

 

Anxiety disorder

16 (1.23)

 

Alcohol intake

15 (1.15)

 

Gastro esophageal reflux disease

15 (1.15)

 

Non-smoker

15 (1.15)

 

Others

917 (70.54)