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Table 4 Comparison of the number of reports for each factor before and after propensity score matching

From: Analysis of drug-induced interstitial lung disease caused by herbal medicine using the Japanese Adverse Drug Event Report database

 

Before propensity score matching

After propensity score matching

Contain

Not Contain

p

Standard mean differences

Contain

Not Contain

p

Standard mean differences

Scutellariae radix (SR)

(n = 1,554)

(n = 2,686)

  

(n = 832)

(n = 832)

  

Sex

  

0.2887

0.0339

  

0.6401

0.0229

 Male

567 (0.3649)

1024 (0.3812)

  

283 (0.3401)

274 (0.3293)

  

 Female

987 (0.6351)

1662 (0.6188)

  

549 (0.6599)

558 (0.6707)

  

Age

  

 < 0.0001*

0.3508

  

0.1045

0.0796

 ≥ 60

862 (0.5547)

1936 (0.7208)

  

466 (0.5601)

433 (0.5204)

  

 < 60

692 (0.4453)

750 (0.2792)

  

366 (0.4399)

399 (0.4796)

  

SR (g)

-

-

  

-

-

  

BR (g)

3.05 ± 3.13

0.38 ± 0.80

 < 0.0001*

1.1688

0.39 ± 1.06

0.36 ± 0.89

0.4580

0.0307

PT (g)

2.29 ± 2.44

0.54 ± 1.59

 < 0.0001*

0.8498

0.88 ± 1.81

0.78 ± 1.81

0.2758

0.0552

Bupleuri radix (BR)

(n = 1,390)

(n = 2850)

  

(n = 993)

(n = 993)

  

Sex

  

0.2627

0.0367

  

0.6046

0.0232

 Male

505 (0.3633)

1086 (0.3811)

  

341 (0.3434)

352 (0.3545)

  

 Female

885 (0.6367)

1764 (0.6189)

  

652 (0.6566)

641 (0.6455)

  

Age (years)

  

0.4587

0.0243

  

 < 0.0001*

0.2173

 ≥ 60

928 (0.6676)

1870 (0.6561)

  

660 (0.6647)

757 (0.7623)

  

 < 60

462 (0.3324)

980 (0.3439)

  

333 (0.3353)

236 (0.2377)

  

SR (g)

1.61 ± 1.42

0.51 ± 0.98

 < 0.0001*

0.9016

1.02 ± 1.25

1.00 ± 1.31

0.7578

0.0156

BR (g)

-

-

  

-

-

  

PT (g)

2.16 ± 2.42

0.70 ± 1.78

 < 0.0001*

0.6873

1.12 ± 1.83

0.94 ± 1.97

0.0382*

0.0947

Pinelliae tuber (PT)

(n = 1,086)

(n = 3,154)

  

(n = 640)

(n = 640)

  

Sex

  

0.0457*

0.0700

  

0.0475*

0.1109

 Male

435 (0.4006)

1156 (0.3665)

  

252 (0.3938)

287 (0.4484)

  

 Female

651 (0.5994)

1998 (0.6335)

  

388 (0.6063)

353 (0.5516)

  

Age

  

 < 0.0001*

0.1931

  

0.6874

0.0225

 ≥ 60

642 (0.5912)

2156 (0.6836)

  

398 (0.6219)

391 (0.6109)

  

 < 60

444 (0.4088)

998 (0.3164)

  

242 (0.3781)

249 (0.3891)

  

SR (g)

1.88 ± 1.32

0.52 ± 1.02

 < 0.0001*

1.1530

1.19 ± 1.24

1.30 ± 1.46

0.1573

0.0812

BR (g)

3.59 ± 3.22

0.58 ± 1.32

 < 0.0001*

1.2232

1.59 ± 2.47

1.44 ± 2.29

0.2428

0.0630

PT (g)

-

-

  

-

-

  
  1. *p-value < 0.05