Table 1 Number of reports and ROR of drug-induced interstitial lung disease for each herbal medicine for analysis of whole data

Total

830079

36745

793334

Scutellariae radix (SR)

1051

308

743

9.0 (7.9 − 10.3)

(Ougon)

Bofutsushosan

410

103

307

7.3 (5.8 − 9.1)

Orengedokuto

185

44

141

6.7 (4.8 − 9.5)

Shin'iseihaito

110

27

83

7.0 (4.6 − 10.8)

Seishinrenshiin

99

51

48

23 (15.5 − 34.1)

Junchoto

46

25

21

25.7 (14.4 − 45.9)

Unseiin

42

13

29

9.7 (5.0 − 18.6)

Seihaito

34

11

23

10.3 (5.0 − 21.2)

Seijobofuto

28

1

27

—

Ryutanshakanto

24

9

15

13.0 (5.7 − 29.6)

Sammotsuogonto

23

11

12

19.8 (8.7 − 44.9)

Nyoshinsan

22

3

19

3.4 (1.0 − 11.5)

Gorinsan

21

6

15

8.6 (3.3 − 22.3)

San'oshashinto

6

4

2

43.2 (7.9 − 235.7)

Ogonto

1

0

1

—

Bupleuri radix (BR)

796

86

710

2.6 (2.1 − 3.3)

(Saiko)

Yokukansan

418

42

376

2.4 (1.8 − 3.3)

Hochuekkito

181

32

149

4.6 (3.2 − 6.8)

Kamishoyosan

153

7

146

1.0 (0.5 − 2.2)

Kamikihito

21

3

18

3.6 (1.1 − 12.2)

Jumihaidokuto

19

2

17

2.5 (0.6 − 11.0)

Shimpito

2

0

2

—

Shigyakusan

1

0

1

—

Jiinshihoto

1

0

1

—

Pinelliae tuber (PT)

482

77

405

4.1 (3.2 − 5.2)

(Hange)

Rikkunshito

158

13

145

1.9 (1.1 − 3.4)

Bakumondoto

131

31

100

6.7 (4.5 − 10.0)

Shoseiryuto

110

20

90

4.8 (3.0 − 7.8)

Hangekobokuto

45

10

35

6.2 (3.1 − 12.5)

Chotosan

14

1

13

—

Hangebyakujutsutemmato

7

1

6

—

Unkeito

6

0

6

—

Bukuryoingohangekobokuto

5

0

5

—

Goshakusan

3

0

3

—

Shohangekabukuryoto

1

0

1

—

Nichinto

1

0

1

—

Ryokankyomishingeninto

1

1

0

—

Orento

0

0

0

—

Jinsoin

0

0

0

—

Tokito

0

0

0

—

SR_BR

277

115

162

15.4 (12.1 − 19.5)

Otsujito

154

82

72

24.6 (17.9 − 33.8)

Saikokeishikankyoto

78

23

55

9.0 (5.5 − 14.7)

Keigairengyuoto

41

8

33

5.2 (2.4 − 11.3)

Saikoseikanto

4

2

2

21.6 (3.0 − 153.1)

SR_PT

231

102

129

17.1 (13.2 − 22.2)

Hangeshashinto

190

81

109

16.1 (12.0 − 21.4)

Nijutsuto

41

21

20

22.7 (12.3 − 41.8)

BR_PT

31

3

28

2.3 (0.7 − 7.6)

Yokukansankachimpihange

28

2

26

1.7 (0.4 − 7.0)

Chikujountanto

3

1

2

—

SR_BR_PT

998

383

615

13.6 (11.9 − 15.4)

Saireito

456

191

265

15.6 (13.0 − 18.8)

Saikokaryukotsuboreito

164

50

114

9.5 (6.8 − 13.2)

Shosaikoto

107

58

49

25.6 (17.5 − 37.4)

Saibokuto

93

29

64

9.8 (6.3 − 15.2)

Saikokeishito

85

23

62

8.0 (5.0 − 12.9)

Daisaikoto

64

25

39

13.8 (8.4 − 22.9)

Shosaikokakikyosekko

25

7

18

8.4 (3.5 − 20.1)

Daisaikotokyodaio

4

0

4

—

Saikanto

0

0

0

—