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Table 5 Pharmacokinetic parameters of HTX

From: In vivo antimalarial effect of 1-hydroxy-5,6,7-trimethoxyxanthone isolated from Mammea siamensis T. Anders. flowers: pharmacokinetic and acute toxicity studies

Parameter

Value

AUC0 − 48 h (ng∙h/mL)

226.200 ± 4.742

AUC0−∞ (ng∙h/mL)

247.227 ± 5.325

Tmax (h)

0.500 ± 0.021

Cmax (ng/mL)

94.020 ± 3.214

t1/2 (h)

13.881 ± 1.231

MRT0−∞ (h)

14.795 ± 0.515

CL/F (mg/kg)/(ng/mL)/h

0.020 ± 0.002

Vz/F (mg/kg)/(ng/mL)

0.405 ± 0.014

V1 (mg/kg)/(ng/mL)

1.633 ± 0.003

V2 (mg/kg)/(ng/mL)

19.808 ± 2.031

K12 (1/h)

1.888 ± 0.013

K21 (1/h)

0.156 ± 0.002

  1. Data expressed as mean ± standard deviation (n = 5). Abbreviations: AUC0 − 48: area under the curve from 0 to 48 h; AUC0−∞: area under the curve from 0 to infinity; tmax: time to reach maximum concentration; Cmax: maximum concentration; t1/2: elimination half-life; MRT0−∞: mean residence time from time zero to infinity; CL/F: apparent total clearance of the drug; Vz/F: apparent volume of distribution during terminal phase after non-intravenous administration; V1: apparent volume, central or plasma compartment in a two-compartment model; V2: apparent volume, peripheral compartment in a two-compartment model; K12: rate constant, central to peripheral compartment; K21: rate constant, peripheral to central compartment.
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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