In vivo antimalarial effect of 1-hydroxy-5,6,7-trimethoxyxanthone isolated from Mammea siamensis T. Anders. flowers: pharmacokinetic and acute toxicity studies

Table 3 Effects of HTX on the biochemical parameters of the liver and kidney functions in the acute toxicity test

Parameters	Untreated control	Negative control	HTX
Liver function test
AST (U/L)	44.00 ± 0.55	44.20 ± 2.27	46.20 ± 2.35
ALT (U/L)	14.60 ± 1.29	15.60 ± 1.15	13.00 ± 3.63
ALP (U/L)	108.60 ± 3.86	106.20 ± 2.27	105.80 ± 2.92
Kidney function test
BUN (mg/dL)	16.80 ± 0.58	18.20 ± 0.33^c	16.00 ± 0.55^b
Creatinine (mg/dL)	0.26 ± 0.01	0.27 ± 0.01	0.25 ± 0.02

Data represent the mean ± SEM (n = 5 per group). Values are significantly different at p < 0.05 : different superscript letters; ^aCompared with untreated control; ^bcompared with negative control (2% DMSO in NSS); ^ccompared with 50 mg/kg HTX.

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