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Table 2 Effects of HTX against Plasmodium parasites in malaria-infected mice

From: In vivo antimalarial effect of 1-hydroxy-5,6,7-trimethoxyxanthone isolated from Mammea siamensis T. Anders. flowers: pharmacokinetic and acute toxicity studies

Groups

Dose (mg/kg)

% parasitemia

% suppression

Negative control

-

33.49 ± 3.01

-

Artesunate

3

3.84 ± 0.54

91.26 ± 3.54 c, d, e

Chloroquine

3

3.42 ± 0.35

92.07 ± 4.21 c, d, e

HTX

1

21.91 ± 2.25

34.56 ± 4.91 a, b, d, e

HTX

3

17.79 ± 2.31

46.88 ± 3.96 a, b, c, e

HTX

10

8.62 ± 1.21

74.26 ± 3.32 a, b, c, d

  1. Data represent the mean ± SEM (n = 5 per group). Values are significantly different at p < 0.05 : different superscript letters. acompared with artesunate; bcompared with chloroquine; ccompared with 1 mg/kg HTX; dcompared with 3 mg/kg HTX; ecompared with 10 mg/kg HTX.
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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