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Table 3 Comparison of stress, anxiety, and depression scores within groups and between groups receiving lavender and placebo at each time point and over time

From: The effect of lavender on mood disorders associated with the use of combined oral contraceptives (COCs): a triple-blinded randomized controlled trial

Variable

 

lavender

placebo

Lavender and placebo

 

Mean

(SD)

Mean change

(95% CI)

P*

Mean

(SD)

Mean change

(95% CI)

P*

Mean difference

(95% CI)

p**

Stress

Before

12.2 (8.2)

-

-

11.9 (8.2)

-

-

-0.3 (-4.5 to 3.92)

0.876&

28 days later

7.6 (5.9)

-4.6 (-6.7 to-2.5)

< 0.001

12 (6.9)

0.1 (-1.4 to 1.7)

0.845

-4.9 (-7.08 to -2.8)

< 0.001

56 days later

7.04 (5.7)

-5.2 (-7.6 to -2.8)

< 0.001

12.4 (6.4)

0.5 (-1.3 to 2.3)

0.575

-5.3 (-7.6 to -3.1)

< 0.001

P***

 

< 0.001

0.798

  

Between lavender and placebo group

 

Mean difference

(95% CI)

P****

P*****

 

-3.81 (-7.2 to -0.3)

0.031

< 0.001

Depression

Before

9.8 (6.3)

-

-

8.5 (5.7)

-

-

-1.3 (-4.4 to 1.7)

0.396&

28 days later

6.1 (5.03)

-3.7 (-5.5 to -1.8)

< 0.001

8.3 (4.5)

-0.1 (-1.7 to 1.3)

0.809

-3.04 (-4.9 to -1.1)

0.003

56 days later

6.2 (4.8)

-3.6 (-5.4 to -1.8)

< 0.001

8.9 (5)

0.4 (-1.02 to 1.8)

0.55

-3.1 (-5.03 to 1.2)

0.002

P***

 

< 0.001

0.594

  

Between lavender and placebo group

 

Mean difference

(95% CI)

P****

P*****

 

-1.41 (-3.96 to 1.31)

0.272

0.003

  

Median (IQR)

pI

Median (IQR)

pI

pII

Anxiety

Before

6 (4 to 10)

-

4 (4 to 8)

-

0.023

28 days later

4 (2 to 6)

0.002

4 (2 to 6)

0.399

0.967

56 days later

4 ( 2 to 6 )

0.004

4 (2 to 6)

0.5

0.629

pIII

 

0.001

 

0.206

  
  1. P*: Repeated measure ANOVA (Comparison of each time point with the baseline); P**: Between‑group p values after intervention with ANCOVA adjusted for baseline and age (comparison of lavender group and placebo at each time point); P***: Within-group repeated measure ANOVA; P****: Between‑group repeated measure ANOVA adjusted for age during the time; P*****: Greenhouse-Geisser or Sphericity Assumed test adjusted for age (time and group interaction); pI: Wilcoxon test;pII: Mann_whitney test; pIII: Friedman test; SD: Standard deviation; CI: Confidence interval; &: Independent T-test