Table 2 KEGG analysis results of common targets

hsa05200

Pathways in cancer

42

7.60

GSK3B, CDKN1A, HSP90AB1, FLT3, PIK3R1, PTGS2, HIF1A, RELA, EGFR, IGF1R, CASP9, CASP8, RXRA, TERT, CASP3, AKT1, PRKACA, HRAS, TGFB1, NOS2, STAT1, MMP2, PRKCA, FOS, F2, MMP9, ESR1, MTOR, PTK2, ESR2, VEGFA, AR, CDK6, IFNG, KIT, CDK2, BAX, PPARG, CALM1, MET, TP53, BCL2L1

5.57E-27

hsa05417

Lipid and atherosclerosis

25

11.17

GSK3B, HSP90AB1, SRC, PIK3R1, RELA, ICAM1, CASP9, CASP8, RXRA, CASP3, AKT1, APOB, HRAS, MMP3, PRKCA, FOS, MAPK14, MMP9, PTK2, TNFRSF1A, BAX, PPARG, CALM1, TP53, BCL2L1

5.19E-19

hsa05167

PI3K-Akt signaling pathway

25

6.78

GSK3B, CDKN1A, HSP90AB1, FLT3, PIK3R1, RELA, EGFR, PIK3CG, IGF1R, CASP9, RXRA, KDR, AKT1, HRAS, PRKCA, MTOR, PTK2, VEGFA, CDK6, KIT, CDK2, PKN1, MET, TP53, BCL2L1

5.37E-14

hsa01522

Kaposi sarcoma-associated herpesvirus infection

24

11.88

GSK3B, CDKN1A, STAT1, SRC, PIK3R1, FOS, PTGS2, MAPK14, HIF1A, MTOR, PIK3CG, RELA, ICAM1, TNFRSF1A, VEGFA, CASP9, CASP8, CDK6, CASP3, BAX, AKT1, CALM1, HRAS, TP53

8.08E-19

hsa05163

Human cytomegalovirus infection

23

9.82

GSK3B, CDKN1A, SRC, PRKCA, PIK3R1, PTGS2, MAPK14, EGFR, MTOR, RELA, PTK2, TNFRSF1A, VEGFA, CASP9, CASP8, CDK6, CASP3, BAX, AKT1, CALM1, PRKACA, HRAS, TP53

3.36E-16

hsa05205

Proteoglycans in cancer

22

10.31

CDKN1A, TGFB1, SRC, MMP2, PRKCA, PIK3R1, MAPK14, HIF1A, ESR1, MMP9, EGFR, MTOR, PTK2, IGF1R, VEGFA, CASP3, KDR, AKT1, PRKACA, HRAS, MET, TP53

6.83E-16

hsa05215

Human papillomavirus infection

21

6.09

GSK3B, CDKN1A, STAT1, PIK3R1, PTGS2, EGFR, MTOR, RELA, PTK2, TNFRSF1A, VEGFA, CASP8, CDK6, TERT, CASP3, CDK2, BAX, AKT1, PRKACA, HRAS, TP53

8.21E-11

hsa01521

Chemical carcinogenesis - receptor activation

19

8.61

HSP90AB1, SRC, CHRNA7, PRKCA, PIK3R1, FOS, ADRB2, ESR1, EGFR, MTOR, RELA, ESR2, VEGFA, AR, RXRA, CYP1B1, AKT1, PRKACA, HRAS

2.94E-12

hsa04151

Endocrine resistance

18

17.64

CDKN1A, SRC, MMP2, PIK3R1, FOS, MAPK14, ESR1, MMP9, EGFR, MTOR, PTK2, ESR2, IGF1R, BAX, AKT1, PRKACA, HRAS, TP53

6.78E-17

hsa05160

Hepatitis C

18

11.01

GSK3B, CDKN1A, STAT1, PIK3R1, EGFR, RELA, TNFRSF1A, CASP9, CASP8, RXRA, CDK6, IFNG, CASP3, CDK2, BAX, AKT1, HRAS, TP53

2.37E-13

hsa05222

Hepatitis B

18

10.67

CDKN1A, TGFB1, STAT1, SRC, PRKCA, PIK3R1, FOS, MAPK14, MMP9, RELA, CASP9, CASP8, CASP3, CDK2, BAX, AKT1, HRAS, TP53

4.00E-13

hsa05161

Human immunodeficiency virus 1 infection

18

8.15

PRKCA, PIK3R1, FOS, MAPK14, MTOR, RELA, PTK2, TNFRSF1A, CASP9, CASP8, CASP3, CHEK1, CDK1, BAX, AKT1, CALM1, HRAS, BCL2L1

3.22E-11

hsa05418

Fluid shear stress and atherosclerosis

17

11.75

HSP90AB1, SRC, MMP2, PIK3R1, FOS, MAPK14, MMP9, RELA, PTK2, ICAM1, TNFRSF1A, VEGFA, IFNG, KDR, AKT1, CALM1, TP53

4.97E-13

hsa05212

Prostate cancer

16

15.84

GSK3B, CDKN1A, HSP90AB1, MMP3, PIK3R1, MMP9, EGFR, MTOR, RELA, IGF1R, CASP9, AR, CDK2, AKT1, HRAS, TP53

3.30E-14

hsa05207

EGFR tyrosine kinase inhibitor resistance

15

18.24

GSK3B, SRC, PRKCA, PIK3R1, EGFR, MTOR, IGF1R, VEGFA, AXL, KDR, BAX, AKT1, HRAS, MET, BCL2L1

3.53E-14

hsa04919

Small cell lung cancer

15

15.66

CDKN1A, NOS2, PIK3R1, PTGS2, RELA, PTK2, CASP9, RXRA, CDK6, CASP3, CDK2, BAX, AKT1, TP53, BCL2L1

3.21E-13

hsa05170

Thyroid hormone signaling pathway

15

11.91

NCOA2, GSK3B, STAT1, SRC, PRKCA, PIK3R1, HIF1A, ESR1, MTOR, CASP9, RXRA, AKT1, PRKACA, HRAS, TP53

1.53E-11

hsa04926

Relaxin signaling pathway

15

11.17

TGFB1, NOS2, SRC, MMP2, PRKCA, PIK3R1, FOS, MAPK14, MMP9, EGFR, RELA, VEGFA, AKT1, PRKACA, HRAS

3.69E-11

hsa05210

Pancreatic cancer

14

17.69

CDKN1A, TGFB1, STAT1, PIK3R1, EGFR, MTOR, RELA, VEGFA, CASP9, CDK6, BAX, AKT1, TP53, BCL2L1

5.03E-13

hsa05165

Colorectal cancer

13

14.52

GSK3B, CDKN1A, TGFB1, PIK3R1, FOS, EGFR, MTOR, CASP9, CASP3, BAX, AKT1, HRAS, TP53

5.19E-11