Fig. 3

Histological examination by Masson’s trichrome staining of back skin of relative groups. A Roc treatment evaluation showed a decrease in the epidermal thickness which was assessed for each experiment based on the four smooth regions enclosed by red rectangular. B Epidermal thickness values were measured using Image J at day 6. Symbols on the columns indicate the mean ± SEM with n = 6. ^**** P < 0.0001 was compared to the VEH group. ^## P < 0.01 and ^#### P < 0.0001 were compared to the Imiq group