Fig. 2

Illustration of histopathological analysis and spleen weight changes after applying Roc and CsA on psoriatic mice. A The representative histopathology of back skin stained with H&E showed Imiq group has Munro’s microabscesses in the keratin layer, lengthening and clubbing of rete ridges, and moderate-severe dermal lymphocytic infiltrate while Roc 2% was similar to CsA which reversed the Imiq-induces pathologic changes in mice receiving Imiq. B The indications of Baker’s scoring system [15] reflected in the method section were used for histopathology evaluation. C Bars represent Baker’s pathology score after 5 days of applying different treatments with Imiq on the shaved back skin of mice. D Mice’s weight was measured daily for up to 6 days. E A significant decrease in the ratio percentage of the spleen mass to the weight of mice was seen in the Imiq-CsA treatment group. Symbols on the columns indicate the mean ± SEM with n = 6 per group. *** P < 0.001 were compared to the VEH group. ^# P < 0.05, ^## P < 0.01 as compared to the Imiq group