Fig. 1

Topical application of Roc 2% attenuates Imiq-induced inflammation like psoriasis in mice. A The representative mice back skins on day 6 of experiments showed signs of erythema, scaling, and thickening that appeared obviously in untreated psoriatic mice while relative signs were improved in treatment groups at the end of the experiment. B Erythema, Scaling, Thickness, and PASI scores on a scale from 0 to 4 for 6 consecutive days. Data were indicated by the mean ± SEM and n = 6 per group. Green, brown, and dark colors are related to Imiq-CsA, Imiq-Roc, and Imiq groups, respectively. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001 were compared to the VEH group. ^# P < 0.05, ^## P < 0.01, and ^### P < 0.001 were compared to the Imiq group