Molecular mechanism of resveratrol promoting differentiation of preosteoblastic MC3T3-E1 cells based on network pharmacology and experimental validation

Table 1 Basic information of some key targets of Res against OP

UniProt ID	Gene symbol	Protein names	Degree
P31749	AKT1	RAC-alpha serine/threonine-protein kinase	75
P05231	IL6	Interleukin-6	71
P01584	IL1B	Interleukin-1 beta	66
P15692	VEGFA	Vascular endothelial growth factor A	64
P42574	CASP3	Caspase-3	63
P40763	STAT3	Signal transducer and activator of transcription 3	62
Q16644	MAPK3	Mitogen-activated protein kinase 3	60
P01106	MYC	Myc proto-oncogene protein	58
P37231	PPARG	Peroxisome proliferator-activated receptor gamma	57
P35222	CTNNB1	Catenin beta-1	54
P35354	PTGS2	Prostaglandin G/H synthase 2	54
P14780	MMP9	Matrix metalloproteinase-9	52
P10145	CXCL8	C-X-C motif chemokine 8	52
P42345	MTOR	Serine/threonine-protein kinase mTOR	51
Q07817	BCL2L1	Bcl-2-like protein 1	50
P25963	NFKBIA	NF-kappa-B inhibitor alpha	50
P24385	CCND1	G1/S-specific cyclin-D1	49
P22301	IL10	Interleukin-10	48
P04040	CAT	Catalase	47
P45983	MAPK8	Mitogen-activated protein kinase 8	45
P29474	NOS3	Nitric oxide synthase, endothelial	43
P55211	CASP9	Caspase-9	42
Q04206	RELA	Transcription factor p65	41
P28482	MAPK1	Mitogen-activated protein kinase 1	41
Q07869	PPARA	Peroxisome proliferator-activated receptor alpha	41

ISSN: 2662-7671