Antiproliferative activities of some selected Nigerian medicinal plants against breast, liver, and cervical cancer cells

Table 4 Growth inhibitory activity of selected extracts and selectivity index

S/no	Extracts	MCF-7	HUH-7	HeLa	MRC-5	MCF-7	HUH-7	HeLa
		Mean GI₅₀ values (μg/mL)¹				Selectivity index (SI)²
1	DGL	70.73 ± 2.54	51.26 ± 12.05	158.16 ± 40.19	25.25 ± 6.27	0.36	0.49	0.16
2	DGR	4.85 ± 1.54	24.19 ± 6.58	10.5 ± 2.07	34.53 ± 1.55	7.12	1.43	3.29
3	JML	99.74 ± 7.18	50.86 ± 3.63	46.99 ± 13.05	134.71 ± 8.86	1.35	2.65	2.87
4	MCL	3.42 ± 1.80	11.54 ± 2.82	5.23 ± 0.37	48.77 ± 6.53	14.26	4.23	9.6
5	MCSB	50.05 ± 3.56	97.14 ± 2.13	2.87 ± 0.90	23.60 ± 6.66	0.47	0.24	8.22
6	PAR	0.06 ± 0.02	16.70 ± 5.04	7.78 ± 0.91	2.89 ± 0.20	48.17	0.17	0.37
7	PASB	0.36 ± 0.13	25.04 ± 2.94	6.66 ± 1.67	2.20 ± 0.13	6.11	0.09	6.11
8	PLF	53.47 ± 0.71	22.85 ± 4.81	27.82 ± 3.25	101.13 ± 30.89	1.89	4.43	3.64
9	RBR	5.88 ± 0.82	43.22 ± 11.16	13.55 ± 1.53	10.51 ± 1.20	1.79	0.24	0.78
10	RBL	> 250	98.26 ± 27.57	27.37 ± 4.75	41.23 ± 14.80	NA	0.42	1.51
11	RCL	30.13 ± 0.15	166.48 ± 9.28	4.89 ± 0.49	91.02 ± 10.44	3.02	0.55	3.02
12	RCSB	20.81 ± 0.57	42.68 ± 10.43	74.46 ± 9.90	56.37 ± 5.28	2.71	1.32	0.76
13	TSB	78.86 ± 2.93	178.70 ± 43.43	140.35 ± 8.52	95.44 ± 20.24	1.21	0.54	0.68
14	Quercetin	2.39 ± 0.74	8.04 ± 0.31	6.09 ± 1.60	6.09 ± 1.60	2.55	0.76	1.00

¹GI₅₀ values are presented as the mean GI₅₀ ± SD (μg/mL) of at least three independent experiments. ²SI = (GI₅₀ of MRC-5)/(GI₅₀ of MCF-7, HUH-7 or HeLa).There was a significant difference in growth inhibition in extract-treated cultures compared with DMSO-control treated. p < 0.05, versus control (a two-way ANOVA followed by Tukey’s post hoc multiple comparison tests)

ISSN: 2662-7671