Table 4 Physiochemical, medicinal chemistry and drug-likeliness associated properties of studied compounds from the ethanolic extract of Mentha arvensis
| Â | Physiochemical properties | Medicinal Chemistry | Drug Likeliness (Violations of Rules) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Compound name | Molecular Weight (g/mol) | Topological Polar Surface Area (Ã…2) | No. of rotatable bonds | Hydrogen bond donor | Hydrogen bond acceptor | PAINS Alert | Synthetic Accessibility | Lipinski Rule of 5 | Muegge Rule | Ghose Rule |
Oleanolic acid | 456.70 | 57.53 | 1 | 2 | 3 | 0 | 6.08 | 1 | 1 | 3 |
Rosmarinic acid | 360.31 | 144.52 | 7 | 5 | 8 | 1 | 3.38 | 0 | 0 | 0 |
Luteolin | 286.24 | 111.13 | 1 | 4 | 6 | 1 | 3.02 | 0 | 0 | 0 |
isoorientin | 448.38 | 201.28 | 3 | 8 | 11 | 1 | 5.04 | 2 | 3 | 1 |
Ursolic acid | 456.70 | 57.53 | 1 | 2 | 3 | 0 | 6.21 | 1 | 1 | 3 |