Table 1 Factors and their ranges, on which different rules of drug-likeliness evaluate a compound
Rule | Parameters | Range |
|---|---|---|
Lipinski rule of five [42] | Molecular weight |  < 500 Da |
Hydrogen bond Donors |  < 5 | |
Hydrogen Bond Acceptor |  < 10 | |
Lipophilicity of ClogP |  < 5 | |
Ghose filter [43] | ClogP | -0.4 to 5.6 |
Molecular weight | 160 to 480 | |
Molar refractivity | 40- 130 | |
Total number of atoms | 20- 70 | |
Muegge rule [44] | Molecular weight | 200 to 600, |
XLOGP | -2 to 5 | |
Total Polar Surface Area |  ≤ 150 | |
Number of rings |  ≤ 7 | |
Number carbon |  > 4 | |
Number heteroatoms |  > 1 | |
Num. rotatable bonds |  ≤ 15 | |
Hydrogen bond Acceptor |  ≤ 10 | |
Hydrogen bond Donors |  ≤ 5 |