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Fig. 5 | BMC Complementary Medicine and Therapies

Fig. 5

From: Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells deregulation model and network pharmacology

Fig. 5

NOX4 was the core target gene of baicalin. A PPI network topological analysis. Based on gene intersection, this study acquired altogether 44 protein nodes and 10 hub target genes from topological analysis. As shown, the node color represented the score, with deeper and redder nodes meaning higher degree value. B The top 10 hub genes were screened from (A) using CytoHubba. As shown, the node color represented the score, with deeper and redder nodes meaning higher EPC scores. C Molecular docking of NOX4 with baicalin, affinity =  − 9.31 kcal/mol. D NOX4 mRNA expression in GSE132651 based on probe intensity. (*P < 0.05)

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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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