The effectiveness of traditional Japanese medicine Goshajinkigan in irradiation-induced aspermatogenesis in mice

Table 3 Effect of TBI (6Gy) and TJ107 on testicular weight, epididymal spermatozoa, and fertility in male mice

		Group A	Group B	Group C	Group D
Body weight (g)	Day 0	17.314 ± 0.862	17.314 ± 0.862	17.314 ± 0.862	17.314 ± 0.862
	Day 60	28.501 ± 1.080	28.501 ± 1.080	25.425 ± 1.903*	25.425 ± 1.903*
	Day 120	31.779 ± 2.347	31.932 ± 3.021	28.434 ± 2.669*	28.723 ± 2.289*
	Day 150	33.448 ± 1.118	35.250 ± 3.442	27.662 ± 1.360*	30.060 ± 2.173
Testis weight (g)	Day 0	0.064 ± 0.004	0.064 ± 0.004	0.064 ± 0.004	0.064 ± 0.004
	Day 60	0.097 ± 0.003	0.097 ± 0.003	0.044 ± 0.003*	0.044 ± 0.003*
	Day 120	0.098 ± 0.002	0.102 ± 0.006	0.063 ± 0.006*	0.065 ± 0.004*
	Day 150	0.095 ± 0.004	0.106 ± 0.006	0.057 ± 0.004*	0.069 ± 0.004*
Relative testis weight (%)	Day 0	0.389 ± 0.028	0.389 ± 0.028	0.389 ± 0.028	0.389 ± 0.028
	Day 60	0.354 ± 0.013	0.354 ± 0.013	0.177 ± 0.013*	0.177 ± 0.013*
	Day 120	0.312 ± 0.034	0.315 ± 0.024	0.211 ± 0.016*	0.249 ± 0.806*
	Day 150	0.281 ± 0.012	0.285 ± 0.015	0.191 ± 0.019*	0.225 ± 0.016
spermatozoa (× 10⁵)	Day 0	13.600 ± 0.050	13.600 ± 0.050	13.600 ± 0.050	13.600 ± 0.050
	Day 60	18.600 ± 0.530	18.600 ± 0.530	3.935 ± 0.148*	3.935 ± 0.148*
	Day 120	19.585 ± 1.903	26.332 ± 2.790*	3.987 ± 0.588*	8.860 ± 0.391*
	Day 150	22.560 ± 0.533	25.810 ± 0.871*	3.515 ± 0.548*	23.732 ± 2.041^#
Rate of Fertility	Day 150	100% (10/10)	100% (10/10)	40% (4/10)*	100% (10/10)^#

Data are presented as the mean ± standard deviation. Relative testis weight was calculated as a percentage by dividing the combined weight of both testes in milligrams by the body weight in grams. *p < 0.05 vs. Group A; ^#p < 0.05 vs. Group C

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