Table 2 Characteristics of subjects in each cohort
Parameter | Study | Cohort | Group receiving active ingredients | Group receiving placebo | Z* | P* |
|---|---|---|---|---|---|---|
Age (year) | Single-dose | 1 | 29.00 (9.59) | 24.00 (7.07) | −0.23 | 0.83 |
2 | 21.83 (1.47) | 22.00 (0.00) | 0.17 | 0.87 | ||
3 | 23.83 (1.17) | 22.00 (1.41) | −0.69 | 0.51 | ||
4 | 24.00 (2.53) | 24.50 (3.54) | 0.00 | 1.00 | ||
5 | 23.83 (2.04) | 23.00 (1.41) | −0.34 | 0.75 | ||
6 | 23.83 (0.98) | 23.00 (1.41) | 0.00 | 1.00 | ||
7 | 25.67 (1.97) | 25.00 (0.00) | −0.17 | 0.87 | ||
8 | 24.75 (0.96) | 24.00 (1.41) | −0.48 | 0.65 | ||
Multiple-dose | 9 | 24.00 (2.28) | 24.00 (1.41) | 0.17 | 0.87 | |
10 | 23.83 (2.40) | 23.50 (3.54) | 0.00 | 1.00 | ||
11 | 22.50 (1.64) | 22.50 (0.71) | 1.70 | 0.13 | ||
Height (cm) | Single-dose | 1 | 167.00 (8.08) | 168.50 (12.02) | 0.00 | 1.00 |
2 | 165.17 (9.85) | 162.50 (10.61) | −0.34 | 0.74 | ||
3 | 169.17 (7.08) | 169.00 (15.56) | 0.00 | 1.00 | ||
4 | 167.67 (6.98) | 166.00 (8.45) | 0.00 | 1.00 | ||
5 | 168.17 (4.71) | 166.00 (8.49) | −0.17 | 0.87 | ||
6 | 165.17 (12.06) | 164.50 (7.78) | 0.17 | 0.87 | ||
7 | 166.33 (6.95) | 167.00 (14.14) | 0.00 | 1.00 | ||
8 | 166.50 (6.95) | 160.00 (0.00) | −0.70 | 0.48 | ||
Multiple-dose | 9 | 163.00 (9.12) | 164.00 (5.66) | 0.34 | 0.74 | |
10 | 169.50 (7.45) | 172.50 (0.71) | 0.50 | 0.62 | ||
11 | 167.00 (7.32) | 159.00 (12.73) | −0.67 | 0.50 | ||
Weight (kg) | Single-dose | 1 | 57.75 (9.22) | 62.00 (14.14) | 0.46 | 0.64 |
2 | 56.33 (10.54) | 58.00 (4.24) | 0.50 | 0.62 | ||
3 | 58.83 (10.63) | 64.00 (12.73) | 0.67 | 0.50 | ||
4 | 60.83 (8.80) | 58.50 (9.19) | −0.17 | 0.86 | ||
5 | 59.83 (4.31) | 54.50 (7.78) | −1.07 | 0.29 | ||
6 | 58.17 (9.06) | 56.50 (10.61) | −0.51 | 0.61 | ||
7 | 59.00 (7.32) | 56.50 (13.44) | −0.17 | 0.87 | ||
8 | 59.50 (6.66) | 49.50 (0.71) | −1.41 | 0.16 | ||
Multiple-dose | 9 | 58.17 (12.95) | 57.50 (3.54) | 0.00 | 1.00 | |
10 | 62.33 (9.35) | 62.50 (3.54) | 0.17 | 0.87 | ||
11 | 60.42 (8.18) | 54.75 (13.79) | −0.50 | 0.62 | ||
Body mass index (kg/m2) | Single-dose | 1 | 20.59 (1.23) | 21.60 (1.83) | 1.16 | 0.25 |
2 | 20.53 (1.63) | 22.00 (1.26) | 0.83 | 0.40 | ||
3 | 20.41 (2.03) | 22.28 (0.35) | 1.17 | 0.24 | ||
4 | 21.54 (1.73) | 21.14 (1.17) | −0.17 | 0.87 | ||
5 | 21.14 (1.00) | 19.72 (0.82) | −1.50 | 0.13 | ||
6 | 21.25 (1.47) | 20.77 (1.96) | −0.50 | 0.62 | ||
7 | 21.30 (2.08) | 20.07 (1.41) | −0.83 | 0.40 | ||
8 | 21.40 (0.95) | 19.34 (0.28) | −1.62 | 0.11 | ||
Multiple-dose | 9 | 21.24 (1.67) | 21.37 (0.16) | 0.00 | 1.00 | |
10 | 21.58 (1.52) | 21.01 (1.36) | −0.84 | 0.40 | ||
11 | 21.57 (1.39) | 21.43 (2.02) | 0.00 | 1.00 |