Recovery (%) | Intravenous | Oral | ||
---|---|---|---|---|
Oxyresveratrol (10 mg/kg) | Oxyresveratrol + piperine (10 + 1 mg/kg) | Oxyresveratrol (100 mg/kg) | Oxyresveratrol + piperine (100 + 10 mg/kg) | |
Unchanged Oxyresveratrol | ||||
Urine 0-24h | 8.51 ± 7.07 | 5.06 ± 3.22 | 3.70 ± 3.41 | 0.88 ± 0.46 |
Urine 24-48h | 2.87 ± 1.34 | 1.78 ± 1.33 | 0.32 ± 0.08 | 0.27 ± 0.18 |
Feces 0-24h | 0.23 ± 0.20 | 0.17 ± 0.53 | 0.21 ± 0.17 | 0.24 ± 0.43 |
Feces 24-48h | 0.17 ± 0.16 | 0.11 ± 0.01 | 0.11 ± 0.06 | 0.10 ± 0.03 |
Oxyresveratrol glucuronide | ||||
Urine 0-24h | 29.44 ± 28.07 | 10.55 ± 9.71 | 9.89 ± 6.90 | 7.81 ± 6.68 |
Urine 24-48h | 1.39 ± 0.73 | 0.71 ± 0.57 | 3.07 ± 2.69 | 0.09 ± 0.05* |
Feces 0-24h | 0.20 ± 0.16 | 0.63 ± 0.58 | 0.19 ± 0.16 | 0.10 ± 0.08 |
Feces 24-48h | 0.30 ± 0.29 | 0.18 ± 0.01 | 0.20 ± 0.18 | 0.14 ± 0.06 |