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Table 3 Percent recovery of oxyresveratrol alone and in combination with piperine

From: Comparative pharmacokinetics of oxyresveratrol alone and in combination with piperine as a bioenhancer in rats

Recovery (%)

Intravenous

Oral

Oxyresveratrol (10 mg/kg)

Oxyresveratrol + piperine (10 + 1 mg/kg)

Oxyresveratrol (100 mg/kg)

Oxyresveratrol + piperine (100 + 10 mg/kg)

Unchanged Oxyresveratrol

 Urine 0-24h

8.51 ± 7.07

5.06 ± 3.22

3.70 ± 3.41

0.88 ± 0.46

 Urine 24-48h

2.87 ± 1.34

1.78 ± 1.33

0.32 ± 0.08

0.27 ± 0.18

 Feces 0-24h

0.23 ± 0.20

0.17 ± 0.53

0.21 ± 0.17

0.24 ± 0.43

 Feces 24-48h

0.17 ± 0.16

0.11 ± 0.01

0.11 ± 0.06

0.10 ± 0.03

Oxyresveratrol glucuronide

 Urine 0-24h

29.44 ± 28.07

10.55 ± 9.71

9.89 ± 6.90

7.81 ± 6.68

 Urine 24-48h

1.39 ± 0.73

0.71 ± 0.57

3.07 ± 2.69

0.09 ± 0.05*

 Feces 0-24h

0.20 ± 0.16

0.63 ± 0.58

0.19 ± 0.16

0.10 ± 0.08

 Feces 24-48h

0.30 ± 0.29

0.18 ± 0.01

0.20 ± 0.18

0.14 ± 0.06

  1. Data are presented as mean ± S.D. (n = 6), *p < 0.05 for Oxyresveratrol alone vs Oxyresveratrol + piperine