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Table 3 Percent recovery of oxyresveratrol alone and in combination with piperine

From: Comparative pharmacokinetics of oxyresveratrol alone and in combination with piperine as a bioenhancer in rats

Recovery (%) Intravenous Oral
Oxyresveratrol (10 mg/kg) Oxyresveratrol + piperine (10 + 1 mg/kg) Oxyresveratrol (100 mg/kg) Oxyresveratrol + piperine (100 + 10 mg/kg)
Unchanged Oxyresveratrol
 Urine 0-24h 8.51 ± 7.07 5.06 ± 3.22 3.70 ± 3.41 0.88 ± 0.46
 Urine 24-48h 2.87 ± 1.34 1.78 ± 1.33 0.32 ± 0.08 0.27 ± 0.18
 Feces 0-24h 0.23 ± 0.20 0.17 ± 0.53 0.21 ± 0.17 0.24 ± 0.43
 Feces 24-48h 0.17 ± 0.16 0.11 ± 0.01 0.11 ± 0.06 0.10 ± 0.03
Oxyresveratrol glucuronide
 Urine 0-24h 29.44 ± 28.07 10.55 ± 9.71 9.89 ± 6.90 7.81 ± 6.68
 Urine 24-48h 1.39 ± 0.73 0.71 ± 0.57 3.07 ± 2.69 0.09 ± 0.05*
 Feces 0-24h 0.20 ± 0.16 0.63 ± 0.58 0.19 ± 0.16 0.10 ± 0.08
 Feces 24-48h 0.30 ± 0.29 0.18 ± 0.01 0.20 ± 0.18 0.14 ± 0.06
  1. Data are presented as mean ± S.D. (n = 6), *p < 0.05 for Oxyresveratrol alone vs Oxyresveratrol + piperine