Acute and repeated toxicological study of Myelophil, an ethanol extract of a mixture of Astragali Radix and Salviae Miltiorrhizae Radix, in beagle dogs

Table 2 Summary of the repeated toxicity test in beagle dogs

MYP (mg/kg per day)	0	312.5	625	1250
Number (M/F)	10 (5/5)	6(3/3)	6(3/3)	10 (5/5)
Mortality	–	–	–	–
Anorexia	−+	−+	−+	−+
Soft stool	+	+	++	+++
Compound-colored stool	–	–	++	+++
Food intake	NAD	NAD	NAD	NAD
Ophthalmological findings	NAD	NAD	NAD	NAD
Relative organ weight	NS	NS	NS	NS
Necropsy findings	NAD	NAD	NAD	NAD

Beagle dogs in each group were fed MYP, and the clinical symptoms, including mortality, were monitored for 13 weeks. At the end of the experiment, ophthalmological, necropsy-based examinations were performed
NAD No abnormality detected, NS Not significant; −: Absent; +: Slight; ++: Moderate; +++: Severe; −+: Sporadically detected

ISSN: 2662-7671