Table 5 General appearance and biochemical markers indicating liver and kidney functions before and after cucurbitacin B treatment
From: Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats
Parameters | Cucurbitacin B 0.1 mg/kg IV | Cucurbitacin B 2 mg/kg PO | Cucurbitacin B 4 mg/kg PO | |||
|---|---|---|---|---|---|---|
Pre-dosing (0 h) | Post-dosing (24 h) | Pre-dosing (0 h) | Post-dosing (24 h) | Pre-dosing (0 h) | Post-dosing (24 h) | |
General appearance | Normal | Normal | Normal | Normal | Normal | Normal |
AST (U/L) | 35.40 ± 4.15 | 49.20 ± 3.27 | 36.67 ± 1.53 | 32.33 ± 11.68 | 33.50 ± 8.10 | 50.25 ± 0.96 |
ALT (U/L) | 11.40 ± 6.31 | 11.00 ± 3.94 | 11.00 ± 1.00 | 6.33 ± 1.53 | 16.75 ± 6.50 | 12.25 ± 5.62 |
Creatinine (mg/dL) | 0.22 ± 0.03 | 0.23 ± 0.02 | 0.20 ± 0.02 | 0.19 ± 0.03 | 0.23 ± 0.02 | 0.22 ± 0.03 |