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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Lancemaside A, a major triterpene saponin of Codonopsis lanceolata enhances regulation of nitric oxide synthesis via eNOS activation

Fig. 4

Effects of LA on eNOS phosphorylation via the PI3K/Akt signaling pathway in HUVECs. HUVECs treated with LA (15 μM) for 20 min and co-incubated with or without PI3K inhibitor (LY294002, 25 μM) and an Akt phosphorylation inhibitor (A6730, 5 μM) for 15 h. a Phosphorylation of eNOS and Akt was inhibited by LY294002; however, it was enhanced by treatment with LA, and (b) A6730 also suppressed the phosphorylation of eNOS and Akt, but their phosphorylation was improved by LA treatment

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