Fig. 7From: Physalin A regulates the Nrf2 pathway through ERK and p38 for induction of detoxifying enzymesThe hypothetical Nrf2 pathway model induced by physalin A. Physalin A induces the Nrf2 activation and nuclear translocation through Erk or p38 kinase phosphorylation. In the nucleus, ARE binding of Nrf2 induces detoxification gene expression such as NQO-1, HO-1, and QR.Back to article page