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Fig. 2 | BMC Complementary and Alternative Medicine

Fig. 2

From: Extracts from Sageretia thea reduce cell viability through inducing cyclin D1 proteasomal degradation and HO-1 expression in human colorectal cancer cells

Fig. 2

Induction of cyclin D1 degradation by STL and STB through Thr286 phosphorylation of cyclin D1. a SW480 cells were pretreated with MG132 (20 μM) and then co-treated with STL and STB for additional 6 h. b SW480 cells were treated with STL and STB for the indicated times. (c) SW480 cells were transfected with HA-tagged wild type cyclin D1 construct or HA-tagged T286A cyclin D1 construct for 48 h, and then co-treated with STL and STB for the additional 6 h. Actin was used as loading control. *P < 0.05 compared to the cells without STL and STB

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