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Table 3 Effect of oral administration of OE on hematological parameters

From: An oral toxicity test in rats and a genotoxicity study of extracts from the stems of Opuntia ficus-indica var. saboten

Tests

Male

Female

G1

G2

G3

G4

G1

G2

G3

G4

RBC (106/μL)

6.91 ± 0.43

7.23 ± 0.27

6.85 ± 0.38

6.81 ± 0.17

7.05 ± 0.16

7.25 ± 0.25

7.05 ± 0.08

6.89 ± 0.31

HGB (g/dL)

13.5 ± 0.6

14.2 ± 0.2

13.6 ± 0.7

13.7 ± 0.3

13.9 ± 0.2

14.1 ± 0.3

13.8 ± 0.1

13.6 ± 0.7

HCT (%)

40.8 ± 2.0

42.7 ± 0.8

41.3 ± 1.9

40.5 ± 0.6

40.7 ± 0.3

41.7 ± 0.7

40.6 ± 0.3

40.1 ± 1.6

MCV (fL)

59.1 ± 0.9

59.1 ± 1.1

60.3 ± 0.8

59.5 ± 0.6

57.8 ± 1.0

57.6 ± 1.0

57.5 ± 0.8

58.2 ± 0.5

MCH (pg)

19.5 ± 0.3

19.6 ± 0.5

19.8 ± 0.5

20.1 ± 0.5

19.8 ± 0.4

19.4 ± 0.4

19.6 ± 0.3

19.7 ± 0.2

MCHC (g/dL)

32.9 ± 0.2

33.2 ± 0.2

32.9 ± 1.0

33.8 ± 0.8

34.3 ± 0.5

33.7 ± 0.4

34.0 ± 0.2

33.9 ± 0.7

RDW (%)

12.6 ± 0.8

11.8 ± 0.1

12.9 ± 0.7

12.3 ± 0.3

11.4 ± 0.3

11.4 ± 0.3

11.4 ± 0.4

12.2 ± 0.3*

HDW (g/dL)

2.32 ± 0.07

2.21 ± 0.05

2.22 ± 0.04

2.22 ± 0.07

2.16 ± 0.08

2.17 ± 0.10

2.09 ± 0.06

2.24 ± 0.05

PLT (103/μL)

1404.7 ± 280.7

1196.7 ± 292.9

1274.3 ± 31.8

1149.7 ± 133.6

1078.0 ± 128.6

1091.7 ± 72.0

1132.3 ± 80.1

1204.7 ± 88.4

MPV (fL)

5.50 ± 0.17

5.57 ± 0.23

5.53 ± 0.23

5.60 ± 0.17

5.40 ± 0.17

5.67 ± 0.21

5.40 ± 0.26

5.37 ± 0.06

WBC (103/μL)

5.56 ± 2.15

6.23 ± 1.90

7.40 ± 3.07

5.63 ± 1.12

4.33 ± 1.75

4.89 ± 1.32

3.75 ± 0.78

4.86 ± 1.65

NEU (103/μL)

0.4 ± 0.1

0.5 ± 0.1

0.5 ± 0.2

0.4 ± 0.2

0.3 ± 0.1

0.5 ± 0.3

0.3 ± 0.1

0.4 ± 0.2

LYM (103/μL)

5.0 ± 1.9

5.5 ± 1.7

6.6 ± 2.7

5.0 ± 0.9

3.8 ± 1.6

4.1 ± 1.3

3.3 ± 0.7

4.3 ± 1.3

MON (103/μL)

0.15 ± 0.09

0.14 ± 0.05

0.19 ± 0.10

0.16 ± 0.04

0.10 ± 0.05

0.10 ± 0.06

0.08 ± 0.04

0.09 ± 0.03

EOS (103/μL)

0.03 ± 0.01

0.04 ± 0.02

0.04 ± 0.01

0.03 ± 0.01

0.06 ± 0.02

0.08 ± 0.05

0.05 ± 0.01

0.08 ± 0.04

BAS (103/μL)

0.01 ± 0.01

0.01 ± 0.01

0.02 ± 0.01

0.01 ± 0.01

0.00 ± 0.01

0.00 ± 0.00

0.01 ± 0.01

0.01 ± 0.01

LUC (103/μL)

0.04 ± 0.02

0.03 ± 0.01

0.06 ± 0.04

0.03 ± 0.01

0.02 ± 0.02

0.03 ± 0.01

0.03 ± 0.02

0.03 ± 0.01

  1. G1: negative control vehicle treated group; G2: 500 mg/kg OE treated group; G3: 1000 mg/kg OE treated group; G4: 2000 mg/kg OE treated group
  2. RBC: erythrocyte; HGB: hemoglobin: HCT: hematocrit; MCV: mean corpuscular volume: MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: Red cell distribution width; HDW: Hemoglobin distribution width; PT: Platelet; MPV: Mean platelet volume; WBC: white blood cell; NEU: Neutrophil; LYM: Lymphocyte; MON: Monocyte; EOS: Eosinophil; BAS: Basophils; LUC: Large unstained cell. Data are expressed as mean ± SD. *Significant difference at P < 0.05 levels compared with the G1 group. Bonferroni’s post hoc test was used following a one-way ANOVA vs. G1, and the homogeneity of variance was tested using Levene’s test