Fig. 4

COE promoted apoptosis of the HCC cells. The HepG2/mTOR⁺ cells were treated with 0.1%DMSO as solvent control, or 2 mg/L DDP, or different concentrations of COE (20, 40, 80 mg/L) for 24 h. a and b the apoptosis was detected by Flow cytometry. c-f the protein expression of Bcl-2, Bcl-2 L12, Bax, and Caspase-3 were examined by Western blots. (^**P < 0.01, ^***P < 0.001, compared with the vehicle)