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Table 2 The main pharmacokinetic parameters after oral administration of 25, 50, and 100 mg/kg for MOIG, and 1650 mg/kg for MO or intravenous administration of 25 mg/kg MOIG in female rats (n = 3, mean ± SD)

From: Pharmacokinetics and tissue distribution of monotropein and deacetyl asperulosidic acid after oral administration of extracts from Morinda officinalis root in rats

Parameters Component po-MOIG-25 po-MOIG-50 po-MOIG-100 po-MO-1650 iv-MOIG-25
AUC0-t (μg·h/L) MON 1988 ± 870 3083 ± 1184 2963 ± 397 1504 ± 244 19,098 ± 4740
DA 3133 ± 1580 6572 ± 884 5727 ± 992 4254 ± 3301 8910 ± 2343
AUC0-∞ (μg·h/L) MON 2040 ± 815 3178 ± 1290 2981 ± 400 1507 ± 243 19,129 ± 4743
DA 3221 ± 1536 6661 ± 935 5785 ± 1024 4308 ± 3367 8945 ± 2349
AUMC0-∞ (μg·h/L) MON 10,005 ± 3510 16,892 ± 14,358 8895 ± 1596 5589 ± 407 17,847 ± 2842
DA 20,444 ± 6912 41,101 ± 9585 29,163 ± 7495 25,789 ± 23,049 9214 ± 715
MRT (h) MON 5.28 ± 2.38 4.78 ± 2.64 2.99 ± 0.43 3.75 ± 0.34 0.98 ± 0.31
DA 6.77 ± 1.35 6.12 ± 0.60 4.99 ± 0.44 5.66 ± 0.71 1.08 ± 0.31
t1/2 (h) MON 3.61 ± 1.03 4.01 ± 2.35 2.08 ± 0.50 2.51 ± 0.34 1.76 ± 1.32
DA 4.43 ± 1.12 3.66 ± 0.35 3.64 ± 0.43 3.38 ± 0.44 2.20 ± 1.86
Tmax (h) MON 0.94 ± 0.00 1.33 ± 0.29 0.92 ± 0.14 0.92 ± 0.14 0.03 ± 0.00
DA 2.17 ± 0.76 1.83 ± 0.58 2.33 ± 0.58 2.08 ± 1.18 0.03 ± 0.00
Vd (L/g) MON 0.08 ± 0.05 0.09 ± 0.04 0.10 ± 0.04 4.07 ± 1.16 0.003 ± 0.002
DA 0.07 ± 0.06 0.04 ± 0.01 0.09 ± 0.01 2.50 ± 1.25 0.009 ± 0.006
CL (L/g·h) MON 0.014 ± 0.005 0.018 ± 0.009 0.034 ± 0.05 1.114 ± 0.183 0.001 ± 0.000
DA 0.010 ± 0.006 0.008 ± 0.001 0.018 ± 0.003 0.532 ± 0.287 0.003 ± 0.001
Cmax (μg/L) MON 475 ± 160 761 ± 184 899 ± 197 405 ± 102 25,719 ± 12,174
DA 445 ± 218 863 ± 112 966 ± 171 584 ± 419 12,340 ± 5992
F (%) MON 10.66 ± 4.26 8.31 ± 3.37 3.90 ± 0.52 3.94 ± 0.64
DA 36.01 ± 17.17 37.23 ± 5.23 16.17 ± 2.86 24.08 ± 18.82