From: Assessment of acute, 14-day, and 13-week repeated oral dose toxicity of Tiglium seed extract in rats
 | Dose of Tiglium seed (mg/kg) | ||||||
---|---|---|---|---|---|---|---|
0a | 31.25 | 62.5 | 125 | 250 | 500 | ||
Males | |||||||
 Liver | (g) | 10.564 ± 0.488 | 10.654 ± 0.516 | 10.171 ± 0.727 | 10.782 ± 0.883 | 10.378 ± 0.862 | 9.816 ± 0.560 |
(%BW) | 3.188 ± 0.109 | 3.303 ± 0.162 | 3.195 ± 0.144 | 3.331 ± 0.204 | 3.301 ± 0.226 | 3.216 ± 0.179 | |
 Kidney | (g) | 0.991 ± 0.023 | 0.981 ± 0.044 | 0.957 ± 0.063 | 0.987 ± 0.066 | 0.965 ± 0.087 | 0.934 ± 0.049 |
(%BW) | 0.300 ± 0.015 | 0.304 ± 0.017 | 0.301 ± 0.016 | 0.305 ± 0.012 | 0.307 ± 0.015 | 0.306 ± 0.012 | |
 Testis | (g) | 1.408 ± 0.050 | 1.420 ± 0.066 | 1.396 ± 0.066 | 1.439 ± 0.075 | 1.426 ± 0.060 | 1.439 ± 0.119 |
(%BW) | 0.426 ± 0.023 | 0.440 ± 0.015 | 0.439 ± 0.023 | 0.445 ± 0.024 | 0.454 ± 0.024 | 0.471 ± 0.036* | |
 Thymus | (g) | 0.228 ± 0.011 | 0.231 ± 0.025 | 0.209 ± 0.027 | 0.206 ± 0.013 | 0.198 ± 0.017* | 0.190 ± 0.024* |
(%BW) | 0.069 ± 0.005 | 0.071 ± 0.005 | 0.066 ± 0.010 | 0.064 ± 0.004 | 0.063 ± 0.003 | 0.062 ± 0.008 | |
 Heart | (g) | 0.937 ± 0.058 | 0.915 ± 0.039 | 0.933 ± 0.063 | 0.922 ± 0.049 | 0.910 ± 0.051 | 0.902 ± 0.047 |
(%BW) | 0.282 ± 0.010 | 0.283 ± 0.008 | 0.293 ± 0.009 | 0.285 ± 0.010 | 0.289 ± 0.007 | 0.295 ± 0.009* | |
 Lung | (g) | 1.234 ± 0.050 | 1.171 ± 0.069 | 1.181 ± 0.063 | 1.216 ± 0.125 | 1.181 ± 0.100 | 1.197 ± 0.071 |
(%BW) | 0.373 ± 0.016 | 0.363 ± 0.019 | 0.371 ± 0.016 | 0.377 ± 0.051 | 0.376 ± 0.022 | 0.392 ± 0.026 | |
Females | |||||||
 Liver | (g) | 5.176 ± 0.348 | 5.293 ± 0.150 | 5.257 ± 0.249 | 5.212 ± 0.189 | 5.126 ± 0.350 | 5.152 ± 0.204 |
(%BW) | 2.844 ± 0.193 | 2.872 ± 0.090 | 2.917 ± 0.192 | 2.887 ± 0.160 | 2.849 ± 0.168 | 2.885 ± 0.106 | |
 Kidney | (g) | 0.578 ± 0.039 | 0.580 ± 0.027 | 0.586 ± 0.026 | 0.577 ± 0.030 | 0.581 ± 0.034 | 0.586 ± 0.022 |
(%BW) | 0.317 ± 0.019 | 0.315 ± 0.016 | 0.324 ± 0.009 | 0.319 ± 0.012 | 0.323 ± 0.016 | 0.328 ± 0.010 | |
 Thymus | (g) | 0.191 ± 0.008 | 0.192 ± 0.014 | 0.189 ± 0.014 | 0.193 ± 0.024 | 0.184 ± 0.024 | 0.185 ± 0.016 |
(%BW) | 0.105 ± 0.004 | 0.104 ± 0.006 | 0.105 ± 0.007 | 0.107 ± 0.015 | 0.102 ± 0.012 | 0.103 ± 0.009 | |
 Heart | (g) | 0.579 ± 0.026 | 0.578 ± 0.024 | 0.575 ± 0.029 | 0.567 ± 0.044 | 0.562 ± 0.030 | 0.574 ± 0.021 |
(%BW) | 0.318 ± 0.015 | 0.314 ± 0.008 | 0.318 ± 0.010 | 0.313 ± 0.014 | 0.312 ± 0.011 | 0.321 ± 0.008 | |
 Lung | (g) | 0.923 ± 0.112 | 0.822 ± 0.061 | 0.851 ± 0.055 | 0.868 ± 0.081 | 0.854 ± 0.036 | 0.855 ± 0.051 |
(%BW) | 0.507 ± 0.066 | 0.446 ± 0.031 | 0.471 ± 0.027 | 0.481 ± 0.055 | 0.475 ± 0.019 | 0.479 ± 0.037 |