Table 1 Hematological data of male and female F344 rats orally administered with Tiglium seed extract for 13Â weeks
From: Assessment of acute, 14-day, and 13-week repeated oral dose toxicity of Tiglium seed extract in rats
| Â | Dose of Tiglium seed (mg/kg) | |||||
|---|---|---|---|---|---|---|
0a | 31.25 | 62.5 | 125 | 250 | 500 | |
Males | ||||||
 WBC (103/mm3) | 6.1 ± 1.28 | 5.9 ± 0.90 | 6.5 ± 1.16 | 6.9 ± 1.37 | 6.4 ± 1.49 | 5.9 ± 1.60 |
 RBC (106/mm3) | 8.46 ± 0.475 | 8.58 ± 0.282 | 8.52 ± 0.271 | 8.53 ± 0.351 | 8.69 ± 0.431 | 8.53 ± 0.279 |
 HGB (g/dl) | 14.1 ± 0.36 | 14.2 ± 0.26 | 14.2 ± 0.21 | 14.2 ± 0.37 | 14.4 ± 0.49 | 14.3 ± 0.40 |
 HCT (%) | 39.0 ± 2.10 | 39.4 ± 1.31 | 39.2 ± 1.37 | 39.6 ± 1.58 | 40.2 ± 2.10 | 39.6 ± 1.45 |
 PLT (103/mm3) | 528 ± 48.9 | 565 ± 45.5 | 568 ± 37.2 | 556 ± 69.5 | 614 ± 63.5* | 595 ± 36.4 |
 MCV (fl) | 46 ± 0.7 | 46 ± 0.5 | 46 ± 0.4 | 46 ± 0.5 | 46 ± 0.7 | 46 ± 0.5 |
 MCH (pg) | 16.7 ± 0.57 | 16.5 ± 0.42 | 16.7 ± 0.43 | 16.7 ± 0.42 | 16.6 ± 0.45 | 16.7 ± 0.43 |
 MCHC (g/dl) | 36.3 ± 1.20 | 36.0 ± 0.87 | 36.2 ± 0.96 | 35.9 ± 0.77 | 35.9 ± 0.88 | 36.1 ± 1.04 |
 Reticulocytes (/100 RBC) | 1.3 ± 0.54 | 1.1 ± 0.48 | 1.3 ± 0.31 | 1.3 ± 0.43 | 1.2 ± 0.37 | 1.1 ± 0.52 |
 Neutrophils (%) | 22 ± 7.0 | 19 ± 6.4 | 20 ± 5.0 | 20 ± 7.9 | 21 ± 7.4 | 23 ± 5.7 |
 Eosinophils (%) | 0 ± 0.4 | 1 ± 1.0 | 1 ± 0.6 | 0 ± 0.7 | 1 ± 0.7 | 1 ± 1.1 |
 Basophils (%) | 0 ± 0.0 | 0 ± 0.0 | 0 ± 0.0 | 0 ± 0.0 | 0 ± 0.0 | 0 ± 0.0 |
 Lymphocytes (%) | 77 ± 7.2 | 80 ± 6.9 | 79 ± 4.8 | 79 ± 8.0 | 78 ± 7.8 | 76 ± 5.9 |
 Monocytes (%) | 1 ± 1.1 | 1 ± 0.8 | 1 ± 1.0 | 1 ± 1.0 | 1 ± 0.7 | 1 ± 0.7 |
Females | ||||||
 WBC (103/mm3) | 5.3 ± 0.92 | 4.9 ± 0.63 | 5.1 ± 0.69 | 5.1 ± 0.82 | 5.0 ± 1.23 | 4.3 ± 0.77 |
 RBC (106/mm3) | 7.59 ± 0.380 | 7.55 ± 0.369 | 7.49 ± 0.346 | 7.67 ± 0.326 | 7.68 ± 0.309 | 7.48 ± 0.293 |
 HGB (g/dl) | 13.9 ± 0.40 | 14.0 ± 0.37 | 13.8 ± 0.27 | 14.1 ± 0.40 | 14.2 ± 0.33 | 13.8 ± 0.24 |
 HCT (%) | 37.3 ± 1.55 | 37.4 ± 1.64 | 37.0 ± 1.44 | 37.9 ± 1.50 | 38.1 ± 1.33 | 37.1 ± 1.06 |
 PLT (103/mm3) | 625 ± 47.7 | 623 ± 27.2 | 620 ± 51.8 | 643 ± 60.8 | 649 ± 47.3 | 638 ± 81.4 |
 MCV (fl) | 49 ± 0.5 | 49 ± 0.7 | 50 ± 0.5 | 49 ± 0.4 | 50 ± 0.7 | 50 ± 0.7 |
 MCH (pg) | 18.3 ± 0.57 | 18.5 ± 0.53 | 18.4 ± 0.53 | 18.4 ± 0.50 | 18.5 ± 0.49 | 18.5 ± 0.65 |
 MCHC (g/dl) | 37.2 ± 0.75 | 37.4 ± 0.86 | 37.2 ± 0.76 | 37.2 ± 0.84 | 37.2 ± 0.77 | 37.3 ± 0.91 |
 Reticulocytes (/100 RBC) | 1.0 ± 0.25 | 1.4 ± 0.39 | 1.3 ± 0.41 | 1.2 ± 0.27 | 1.1 ± 0.43 | 1.3 ± 0.53 |
 Neutrophils (%) | 17 ± 6.0 | 13 ± 3.6 | 18 ± 4.2 | 16 ± 7.7 | 17 ± 5.6 | 20 ± 4.6 |
 Eosinophils (%) | 1 ± 1.0 | 1 ± 0.7 | 1 ± 0.6 | 1 ± 1.2 | 0 ± 0.3 | 1 ± 0.7 |
 Basophils (%) | 0 ± 0.0 | 0 ± 0.0 | 0 ± 0.0 | 0 ± 0.0 | 0 ± 0.0 | 0 ± 0.0 |
 Lymphocytes (%) | 81 ± 5.9 | 86 ± 4.2 | 81 ± 3.9 | 82 ± 7.1 | 82 ± 6.4 | 79 ± 4.8 |
 Monocytes (%) | 1 ± 1.1 | 1 ± 0.5 | 1 ± 0.7 | 1 ± 1.4 | 1 ± 0.9 | 1 ± 1.2 |