Fig. 4

Fisetin/fisetin micelles induce cell apoptosis through mitochondrial pathway. Fisetin/fisetin micelles inducecaspase activation and imbalance of Bax/Bcl-2 in treated SKOV3 cells. a Cells treated with different concentrations of fisetin for 24 h, meanwhile, at the same electric lane, sample from SKOV3 cells treated with the same concentration of fisetin micelles were loaded. DMSO (< 0.1%) diluted in saline was considered as control. GAPDH was used as a loading control. b Densitometric analysis was performed for Bcl-2, Bax, Cleaved-caspase-9 and Cleaved-caspase-3. Values were normalized to GAPDH. P < 0.05 compared to control