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Table 11 Binding affinities (kJ/mol) and in vitro inhibitory activity (IC50) of different PLA2 inhibitors

From: Computational investigations of physicochemical, pharmacokinetic, toxicological properties and molecular docking of betulinic acid, a constituent of Corypha taliera (Roxb.) with Phospholipase A2 (PLA2)

Compound name IC50 (μM) [86,87,88] Binding affinity (kJ/mol)
LY 311727 < 1 −39.75
Manoalide 16 −39.33
Indomethacin 35 −36.82
Manoalogue 26 −34.31
Aristolochic Acid 40 −33.89
1,1,1-Trifluoro-2-heptadecanone 45 −27.20