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Table 2 Effect of cisplatin (CP) and different treatments of AHE on lungs tissue antioxidant enzymes and GSH profile

From: Acacia hydaspica R. Parker ameliorates cisplatin induced oxidative stress, DNA damage and morphological alterations in rat pulmonary tissue

Group GSH (μM/g tissue) GR (nM/min/mg protein) GST (nM/min/mg protein) γ-GT (nM/min/mg Protein) GPx (nM/min/mg Protein)
Control 16.12 ± 0.578b 143.7 ± 1.342b 98.85 ± 0.918b 295.4 ± 1.113b 107.4 ± 0.730b
CP 8.334 ± 0.356a 98.02 ± 0.619a 68.17 ± 0.962a 82.82 ± 0.958a 54.08 ± 0.909a
AHE alone 6.38 ± 0.207b 144.0 ± 1.492b 99.79 ± 1.865 b 295.6 ± 0.599b 108.8 ± 1.216b
CP + AHE 11.99 ± 0.305a,b,d 116.9 ± 0.813a,b,d 78.34 ± 1.076a,b**,d** 137.8 ± 1.017a,b,d 71.28.8 ± 0.501a,b,c
AHE + CP 15.63 ± 0.532b,c 135.0 ± 0.393 a,b,c 89.65 ± 1.49 a**,b,c 261.4 ± 0.802a,b,c 92.78 ± 1.216a,b,c
CP + Sily 15.29 ± 0.312b 133.8 ± 1.25a,b 87.60 ± 1.644a,b 264.3 ± 1.067a,b 95.64 ± 1.573a,b
  1. Values expressed as mean ± SEM. a: Significance at p < 0.0001 Vs. control group, b: Significance at p < 0.0001 Vs. Cisplatin (CP) group. c: Significance at p < 0.0001 of AHE + CP pre-treated group Vs. CP + AHE post-treated group. d: Significance at p < 0.0001 of CP + AHE treatment groups Vs CP + Sily group. *, **: Significant difference at < 0.05 and p < 0.001 respectively. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters (One way ANOVA followed by Tukey’s multiple comparison tests)