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Table 3 Results of the in vivo micronucleus test for SOCG

From: Genotoxicity evaluation of So-ochim-tang-gamibang (SOCG), a herbal medicine

Dose (mg/kg) Sampling time (hrs) Number of MNPCE per animal MNPCE/PCE (%) (Mean ± SD) PCE/(PCE + NCE) (%) (Mean ± SD)
M 1 M 2 M 3 M 4 M 5
0 (Water for injection) 24 0 0 0 1 2 0.030 ± 0.045 31.1 ± 4.13
1250 24 0 0 0 3 1 0.040 ± 0.065 30.6 ± 4.94
2500 24 0 0 3 3 2 0.080 ± 0.076 29.2 ± 5.78
5000 24 1 1 1 2 2 0.070 ± 0.027 30.2 ± 2.78
2 (Mitomycin C) 24 172 138 122 174 123 7.290* ± 1.282 25.4 ± 4.07
  1. Significant difference from the negative control by Kastenbaum&Bowman’s criteria: * p < 0.01
  2. Mn: Male animal, n is identification number
  3. MNPCE: micronucleus polychromatic erythrocytes, PCE: polychromatic erythrocytes, NCE: normochromatic erythrocyte