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Table 5 Antidiarrheal effects of the methanol extract of the Baccaurea ramiflora pulp and seed on castor oil induced diarrhea in mice

From: Screening of Baccaurea ramiflora (Lour.) extracts for cytotoxic, analgesic, anti-inflammatory, neuropharmacological and antidiarrheal activities

Group Dose No. of faces in 4 h % inhibition of defecation
Negative Control (1% tween 80 in water) 23.8 ± 1.6
Positive control (loperamide) 3 mg/kg 9.2 ± 1.14* 61.34
MEBRP 100 mg/kg 12 ± 1.6* 50
MEBRP 200 mg/kg 9.6 ± 1.1* 59.7
MEBRS 100 mg/kg 11.6 ± 1* 51.26
MEBRS 200 mg/kg 8.8 ± 1.1* 63.03
  1. Values are means ± S.E.M. of five mice (n = 5)
  2. *p < 0.05 considered as significant compared to control (One-way ANNOVA followed by Dunnet’s test). Control mice received vehicle (1% Tween 80 in water), positive control mice received loperamide 3 mg/kg body weight, MEBRP and MEBRS treated groups were administered with 100 and 200 mg/kg body weight (p.o.), respectively