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Table 3 Depressant effects of the methanol extract of the Baccaurea ramiflora pulp and seed on hole cross test in mice

From: Screening of Baccaurea ramiflora (Lour.) extracts for cytotoxic, analgesic, anti-inflammatory, neuropharmacological and antidiarrheal activities

Group Dose Number of Movements
0 min 30 min 60 min 90 min 120 min
Negative Control (1% tween 80 in water) 9.0 ± 1.26 7.2 ± 1.28 7.6 ± 1.35 9.0 ± 1.26 10 ± 1.26
Positive control (Diazepam) 1 mg/kg, 6.6 ± 1.07* 5.4 ± 1.07* 3.8 ± 0.92* 3.8 ± 1.47* 3 ± 1.26
MEBRP 100 mg/kg 5.2 ± 0.92* 5.0 ± 0.84* 4.8 ± 0.92* 4.6 ± 0.95* 3.8 ± 0.92*
MEBRP 200 mg/kg 4.8 ± 0.92* 4.6 ± 0.74* 3.4 ± 0.74* 3.0 ± 0.84* 2.6 ± 0.74*
MEBRS 100 mg/kg 5.2 ± 1.14* 4.2 ± 1.14* 4.2 ± 1.14* 2.6 ± 1.07* 2 ± 0.84*
MEBRS 200 mg/kg 4.8 ± 0.92* 4.0 ± 0.84* 2.8 ± 0.92* 1.8 ± 0.92* 1 ± 0.84*
  1. Values are means ± S.E.M. of five mice (n = 5)
  2. *p < 0.05 considered as significant compared to control (Dunett’s test). Control mice received vehicle (1% Tween 80 in water), positive control mice received diazepam 1 mg/kg body weight, MEBRP and MEBRS treated groups were administered with 100 and 200 mg/kg body weight (p.o.), respectively