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Table 2 Changes on the mast cells, COX-2-, iNOS- and TNF-α-immunoreactive cells in the hind paw skins

From: Combination of Pelargonium sidoides and Coptis chinensis root inhibits nuclear factor kappa B-mediated inflammatory response in vitro and in vivo

Regions/Cells Normal Carrageenan (CA) CA + Dexamethasone CA + PS + CR 0.3 (g/kg) CA + PS + CR 1.0 (g/kg)
Dorsum pedis skin
 Epidermis (cells/100 epithelial cells)     
  COX-2 + cells 3.60 ± 2.61 77.60 ± 5.94d 27.80 ± 10.57de 59.60 ± 9.71df 36.00 ± 6.52de
  iNOS + cells 4.40 ± 2.30 86.80 ± 5.81a 35.00 ± 7.52ac 73.80 ± 4.32ac 56.40 ± 8.41ac
  TNF-α + cells 1.00 ± 0.71 87.20 ± 6.06a 11.40 ± 4.10bc 70.80 ± 7.46ac 41.40 ± 7.40ac
 Dermis (cells/mm2 of dermis)     
  Mast cells 90.40 ± 15.63 22.00 ± 7.52a 74.20 ± 4.44bc 48.00 ± 13.36ac 64.20 ± 13.59ac
  COX-2 + cells 13.20 ± 6.57 160.00 ± 31.34d 38.80 ± 10.55de 103.80 ± 9.86de 56.20 ± 18.39de
  iNOS + cells 18.60 ± 2.41 379.60 ± 81.04d 78.80 ± 12.13de 216.40 ± 71.14df 109.00 ± 54.16de
  TNF-α + cells 10.20 ± 1.92 175.80 ± 21.31a 47.60 ± 12.93ac 112.20 ± 25.41ac 72.20 ± 17.67ac
Ventrum pedis skin
 Epidermis (cells/100 epithelial cells)     
  COX-2 + cells 3.80 ± 1.70 67.40 ± 4.51a 24.00 ± 7.91ac 53.00 ± 7.18ac 39.40 ± 4.67ac
  iNOS + cells 13.40 ± 3.58 63.00 ± 6.52a 23.40 ± 6.19bc 47.40 ± 6.58ac 35.40 ± 5.13ac
  TNF-α + cells 5.20 ± 2.39 82.00 ± 10.89a 33.00 ± 11.58ac 56.40 ± 6.23ac 40.40 ± 12.60ac
 Dermis (cells/mm2 of dermis)     
  Mast cells 81.60 ± 10.90 7.20 ± 3.35a 57.80 ± 8.01ac 29.20 ± 7.19ac 49.00 ± 10.72ac
  COX-2 + cells 33.40 ± 11.61 823.00 ± 104.48a 146.20 ± 88.37bc 476.40 ± 98.22ac 309.40 ± 79.63ac
  iNOS + cells 27.60 ± 10.62 727.00 ± 102.27a 145.80 ± 50.93bc 485.00 ± 88.26ac 338.00 ± 54.35ac
  TNF-α + cells 19.20 ± 4.60 794.20 ± 110.87d 57.20 ± 17.48de 308.00 ± 56.57de 144.00 ± 40.35de
  1. Values are expressed as mean ± S.D. of five rat hind paws
  2. ap < 0.01 and bp < 0.05 as compared with normal by LSD test. cp < 0.01 as compared with CA by LSD test
  3. dp < 0.01 as compared with normal by MW test. ep < 0.01 and fp < 0.05 as compared with CA by MW test