Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats

Table 4 Effect of cisplatin (CP) and different treatments of AHE on phase II antioxidant enzymes

Group	GSH (μM/g tissue)	GR (nM/min/mg protein)	GST (nM/min/mg protein)	γ-GT (nM/min/mg Protein)	GPx (nM/min/mg Protein)
Control	19.61 ± 0.28 ^b	163.6 ± 0.65 ^b	142.6 ± 0.57 ^b	336.2 ± 0.56 ^b	139.5 ± 1.16 ^b
CP	10.08 ± 0.28 ^a	103.9 ± 0.65 ^a	101.4 ± 0.84 ^a	143.6 ± 1.44 ^a	90.53 ± 1.71 ^a
AHE alone	20.11 ± 0.16 ^b	164.2 ± 0.68 ^b	142.7 ± 0.89 ^b	336.3 ± 1.0 ^b	139.8 ± 0.36 ^b
CP + AHE	12.83 ± 0.21^{a,b d}	122.8 ± 0.65^a,b,d	122.1 ± 0.87^a,b,d	215.3 ± 1.85^a,b,d	108.6 ± 1.25 ^a,b
AHE + CP	18.38 ± 0.29^{a*,b, c}	145.5 ± 0.58^a,b,c	135.3 ± 0.77^{a,b, c}	310.4 ± 0.6 ^a,b,c	128.6 ± 1.74 ^a,b
CP + Sily	18.34 ± 0.11^a*,b	148.7 ± 1.09 ^{a, b}	130.0 ± 0.92 ^{a, b}	309.5 ± 0.69 ^{a, b}	131.8 ± 1.28 ^a,b

Values expressed as mean ± SEM
^a Significance at p < 0.0001 Vs. control group
^b Significance at p < 0.0001 Vs. Cisplatin (CP) group
^c Significance at p < 0.0001 of AHE + CP pre-treated group Vs. CP + AHE post-treated group
^d Significance at p < 0.0001 of CP + AHE treatment groups Vs CP + Sily group
^* Significant difference at p < 0.001. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters (One way ANOVA followed by Tukey’s multiple comparison tests)

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