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Table 5 Non-compartmental pharmacokinetic parameters obtained for metformin (30 mg/kg) after its oral administration with Plantago ovata husk (300 mg/kg) to diabetic rabbits (n = 6)

From: Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits

Parameters Standard chow Supplemented chow p valuesa
\( \overline{x} \) ± SD CV (%) \( \overline{x} \) ± SD CV (%)
λ (min−1) 0.0039 ± 0.0010 25.17 0.0025 ± 0.0014 53.87 0.053a
AUC (μg·min/mL) 1164.9 ± 262.1 22.50 1496.9 ± 438.9 29.32 0.160a
Cmax (μg/mL) 3.39 ± 0.290 8.53 3.12 ± 0.197 6.32 0.087a
tmax (min)c 110.0 ± 15.49 14.08 120.0 ± 0.00 - 0.138b
Cl/F (mL/min/kg) 26.83 ± 5.81 21.67 21.65 ± 6.88 31.76 0.160a
Va/F (mL/kg) 7070.8 ± 884.9 12.52 9317.5 ± 1803.8 19.36 0.022a
Vss/F (mL/kg) 3891.2 ± 731.8 18.81 3080.4 ± 908.7 29.50 0.101a
t1/2λ (min) 189.6 ± 44.7 17.48 336.2 ± 152.6 45.40 0.052a
AUMC (μg·min2/mL) 380,326.9 ± 158,923.7 41.79 827,234.6 ± 560,290.1 67.73 0.093a
MRT (min) 145.9 ± 6.37 4.36 143.1 ± 4.07 2.84 0.409a
MAT (min) 64.21   56.07   
F (%) 36.73   41.52   
  1. at Test
  2. bMann-Whitney Test
  3. csignificant differences with the value obtained when metformin was administered alone (Mann-Whitney Test)