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Table 3 Non-compartmental pharmacokinetic parameters obtained for metformin after its oral administration (30 mg/kg) to diabetic rabbits (n = 6)

From: Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits

Parameters Standard chow Supplemented chow p values
\( \overline{x} \) ± SD CV (%) \( \overline{x} \) ± SD CV (%)
λ (min−1) 0.0046 ± 0.0007 14.43 0.0029 ± 0.0011 39.32 0.014a
AUC (μg·min/mL) 960.6 ± 230.9 24.03 1296.2 ± 331.5 25.57 0.048a
Cmax (μg/mL) 3.23 ± 0.614 19.01 3.09 ± 0.425 13.77 0.694a
tmax (min) 90.0 ± 0.00 - 90.0 ± 0.00 - 1.000b
Cl/F (mL/min/kg) 32.70 ± 7.41 22.67 24.39 ± 5.99 24.55 0.062a
Va/F (mL/kg) 7374.6 ± 2253.7 30.56 9074.9 ± 2680.1 29.53 0.252a
Vss/F (mL/kg) 4416.9 ± 758.8 17.18 3445.3 ± 702.4 20.39 0.046a
t1/2λ (min) 155.3 ± 27.13 17.48 271.6 ± 100.9 37.13 0.014a
AUMC (μg·min2/mL) 245,796.4 ± 65,691.2 26.73 571,150.5 ± 320,022.7 56.03 0.015a
MRT (min) 136.6 ± 8.51 6.23 142.5 ± 6.52 14.50 0.199a
MAT (min) 54.95   52.72   
F (%) 30.29   46.19   
  1. at Test; bMann-Whitney Test