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Table 1 Non-compartmental pharmacokinetic parameters obtained for metformin after its intravenous administration (30 mg/kg) to diabetic rabbits (n = 6)

From: Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits

Parameters Standard chow Supplemented chow p values
\( \overline{x} \) ± SD CV (%) \( \overline{x} \) ± SD CV (%)
λ (min−1) 0.0022 ± 0.0011 50.04 0.0028 ± 0.0008 28.78 0.233a
AUC (μg·min/mL) 3171.9 ± 680.4 21.45 2806.1 ± 471.9 16.82 0.351a
Cl (mL/min/kg) 9.86 ± 2.29 23.20 10.99 ± 2.14 19.47 0.351a
Va (mL/kg) 5137.7 ± 1839.9 35.81 4301.6 ± 1786.6 41.53 0.382a
Vss (mL/kg) 3829.3 ± 1483.7 38.74 3279.1 ± 1174.1 35.81 0.487a
t1/2λ (min) 385.9 ± 47.71 47.71 268.5 ± 85.4 31.80 0.220a
AUMC (μg·min2/mL) 1,411,571.6 ± 915,944.8 64.89 847,182.9 ± 324,044.5 38.25 0.279a
MRT (min) 81.70 ± 3.98 4.87 89.81 ± 13.02 14.50 0.198a
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