Parameters | Standard chow | Supplemented chow | p values | ||
---|---|---|---|---|---|
\( \overline{x} \) ± SD | CV (%) | \( \overline{x} \) ± SD | CV (%) | ||
λ (min−1) | 0.0022 ± 0.0011 | 50.04 | 0.0028 ± 0.0008 | 28.78 | 0.233a |
AUC (μg·min/mL) | 3171.9 ± 680.4 | 21.45 | 2806.1 ± 471.9 | 16.82 | 0.351a |
Cl (mL/min/kg) | 9.86 ± 2.29 | 23.20 | 10.99 ± 2.14 | 19.47 | 0.351a |
Va (mL/kg) | 5137.7 ± 1839.9 | 35.81 | 4301.6 ± 1786.6 | 41.53 | 0.382a |
Vss (mL/kg) | 3829.3 ± 1483.7 | 38.74 | 3279.1 ± 1174.1 | 35.81 | 0.487a |
t1/2λ (min) | 385.9 ± 47.71 | 47.71 | 268.5 ± 85.4 | 31.80 | 0.220a |
AUMC (μg·min2/mL) | 1,411,571.6 ± 915,944.8 | 64.89 | 847,182.9 ± 324,044.5 | 38.25 | 0.279a |
MRT (min) | 81.70 ± 3.98 | 4.87 | 89.81 ± 13.02 | 14.50 | 0.198a |