In vivo effect of Commiphora swynnertonii ethanolic extracts on Trypanosoma congolense and selected immunological components in mice

Table 3 Effect of C. swynnertonii ethanolic stem bark extract on spleen

Treatments	White pulp			Red pulp
Treatments	Perioarteriolar lymphoid sheath (PALS)	Lymphoid follicles	Marginal zone	Red pulp
PBSG (0.1 ml/10 g)	Normal	Normal	Normal	Congestion
TME, 500 mg/kg	No change	No change	No change	Congestion
SE, 500 mg/kg	No change	No change	No change	Congestion
TME, 1500 mg/kg	No change	Marked reduction in cellularity and size, Apoptosis, pyknosis of lymphocytes and tingible body macrophage	Depleted	Cellularity and size severely reduced
SE, 1500 mg/kg	Apoptosis, white foci of variable sizes	-Apoptosis, -white foci of variable sizes, pyknosis of lymphocytes is evident in some of the foci. -Severely reduced in size	No change	Apoptosis, white foci of variable sizes
Infected, treated with 1500 mg/kg of extract but died on 3rd day	Apoptosis and white foci of variable size	-Apoptosis characterized by white foci and pyknosis of lymphocytes	A moderate widening	Congestion
Infected, treated with 2000 mg/kg of extract but died on 2nd day	No change	-Moderate apoptosis characterized with karyorrhexis of lymphocytes -Increased in size	A moderate widening	No change
Infected but not treated, died on 9th day post inoculation	No change	Severely reduced	No change	Increased cellularity and size

ISSN: 2662-7671