Toxicity and antitumor potential of Mesosphaerum sidifolium (Lamiaceae) oil and fenchone, its major component

Table 7 Effects of EOM, fenchone and 5-FU on biochemical parameters of peripheral blood of mice (n=6) subjected to different treatments (9 days)

Groups	Dose, mg/kg	AST, U/L	ALT, U/L	Urea, mg/dL	Creatinine, mg/dL
Healthy animals	-	283.2 ± 24.9	53.6 ± 6.55	39.0 ± 1.9	0.4 ± 0.0
Tumor control	-	242.0 ± 12.2	67,80 ± 7,11	43.0 ± 7.1	0.3 ± 0.0
5-FU	25	199.3 ± 38.4	39.00 ± 9.51	33.2 ± 1.5	0.51 ± 0.02
EOM	50	217.4 ± 27.4	53.8 ± 11,81	27.5 ± 12.0	0.2 ± 0.0
EOM	100	285.4 ± 22.1	60.3 ± 1.43	45.9 ± 5.7	0.2 ± 0.0
EOM	150	320.2 ± 73.9	44.0 ± 6.86	81.8 ± 8.4^a,b	0.6 ± 0.2
Fenchone	30	155.8 ± 7.5^a,b	29,25 ± 2,68^a	38.8 ± 3.8	0.3 ± 0.0
Fenchone	60	163.8 ± 8.5^a,b	34.6 ± 5.4^a	37.8 ± 2.4	0.2 ± 0.0

Data presented as mean ± SEM of six animals analyzed by ANOVA followed by Tukey test. ^a p<0.05 compared to tumor control. ^b p<0.05 compared to healthy animals by ANOVA followed by Tukey

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