Fig. 4From: Apoptosis-induced effects of extract from Artemisia annua Linné by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cellsAAE regulates cytochrome c translocation to the cytoplasm and Bax translocation to the mitochondrial membrane. a AAE regulated cytochrome C translocation from mitochondria to cytosol. Also, (b) AAE induced BAX activation from mitochondria outer membrane to cytosol and BAX/BAK oligomerization. Cell were treated with AAE (40ìg/ml) for 24 h. Target protein and mitochondria were stained with fluorescence lag and cell locations were indicated using a DIC imageBack to article page