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Table 1 The effect of rhubarb its absorbed compound rhein on brain tissues of TBI rats in reduced and oxidized glutathione levels

From: Rhein exhibits antioxidative effects similar to Rhubarb in a rat model of traumatic brain injury

  8 Hour 16 Hour 24 Hour
Group GSH (μmol/L GSSG (μmol/L) GSH/GSSG GSH (μmol/L) GSSG (μmol/L) GSH/GSSG GSH (μmol/L) GSSG (μmol/L) GSH/GSSG
Sham 100.23 ± 7.09 27.29 ± 3.54 3.67 ± 0.65 95.57 ± 8.54 26.98 ± 2.14 3.54 ± 0.33 97.24 ± 8.03 29.34 ± 1.88 3.31 ± 0.29
Vehicle 70.12 ± 6.95# 50.61 ± 4.61# 1.39 ± 0.11# 69.22 ± 7.17# 52.14 ± 3.67# 1.33 ± 0.09# 62.71 ± 6.24# 48.87 ± 3.96# 1.28 ± 0.22#
3 g/kg Rhubarb 71.17 ± 6.25 42.81 ± 4.77* 1.66 ± 0.14* 75.97 ± 6.25* 49.36 ± 4.02 1.54 ± 0.22 74.02 ± 7.14 39.57 ± 4.43* 1.87 ± 0.29*
6 g/kg Rhubarb 72.14 ± 7.47 38.21 ± 3.31 1.89 ± 0.17 79.64 ± 8.24* 48.74 ± 3.49* 1.63 ± 0.16* 83.81 ± 8.16 32.88 ± 2.82 2.55 ± 0.27
12 g/kg Rhubarb 85.62 ± 7.15 35.78 ± 4.11 2.39 ± 0.27 89.27 ± 8.07 33.96 ± 3.51 2.63 ± 0.29 92.55 ± 8.43 31.34 ± 2.5 2.95 ± 0.32
12 mg/kg Rhein 78.69 ± 7.06 34.28 ± 3.84 2.30 ± 0.25 93.74 ± 8.84 41.44 ± 3.87 2.26 ± 0.18 90.87 ± 8.31 35.35 ± 3.47 2.57 ± 0.18
  1. Each value represents mean ± SD (n = 6). Sham group (shame-operated control), Vehicle group (orally given vehicle), 10 mg/kg HSYA (orally given 10 mg/kg HSYA) and 30 mg/kg HSYA (30 mg/kg orally given HSYA). # p < 0.01 as compared to sham, p < 0.01 as compared to vehicle and * p < 0.05 as compared to vehicle